全文获取类型
收费全文 | 3144篇 |
免费 | 319篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 134篇 |
妇产科学 | 57篇 |
基础医学 | 347篇 |
口腔科学 | 72篇 |
临床医学 | 383篇 |
内科学 | 555篇 |
皮肤病学 | 133篇 |
神经病学 | 143篇 |
特种医学 | 169篇 |
外科学 | 426篇 |
综合类 | 272篇 |
现状与发展 | 30篇 |
一般理论 | 1篇 |
预防医学 | 331篇 |
眼科学 | 49篇 |
药学 | 185篇 |
中国医学 | 21篇 |
肿瘤学 | 153篇 |
出版年
2024年 | 19篇 |
2023年 | 199篇 |
2022年 | 82篇 |
2021年 | 103篇 |
2020年 | 114篇 |
2019年 | 61篇 |
2018年 | 106篇 |
2017年 | 85篇 |
2016年 | 87篇 |
2015年 | 105篇 |
2014年 | 138篇 |
2013年 | 155篇 |
2012年 | 187篇 |
2011年 | 169篇 |
2010年 | 168篇 |
2009年 | 152篇 |
2008年 | 127篇 |
2007年 | 147篇 |
2006年 | 110篇 |
2005年 | 100篇 |
2004年 | 96篇 |
2003年 | 112篇 |
2002年 | 80篇 |
2001年 | 64篇 |
2000年 | 73篇 |
1999年 | 77篇 |
1998年 | 56篇 |
1997年 | 59篇 |
1996年 | 56篇 |
1995年 | 39篇 |
1994年 | 39篇 |
1993年 | 34篇 |
1992年 | 16篇 |
1991年 | 19篇 |
1990年 | 14篇 |
1989年 | 36篇 |
1988年 | 30篇 |
1987年 | 20篇 |
1986年 | 13篇 |
1985年 | 15篇 |
1984年 | 12篇 |
1983年 | 7篇 |
1982年 | 9篇 |
1981年 | 11篇 |
1980年 | 13篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 16篇 |
1975年 | 14篇 |
1974年 | 5篇 |
排序方式: 共有3486条查询结果,搜索用时 15 毫秒
71.
GCH1 attenuates cardiac autonomic nervous remodeling in canines with atrial‐tachypacing via tetrahydrobiopterin pathway regulated by microRNA‐206
下载免费PDF全文
![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
72.
Jessica C Fanzo Matthew M Graziose Klaus Kraemer Stuart Gillespie Jessica L Johnston Saskia de Pee Eva Monterrosa Jane Badham Martin W Bloem Alan D Dangour Richard Deckelbaum Achim Dobermann Patrizia Fracassi SM Moazzem Hossain John Ingram Johann C Jerling CJ Jones Stefanus Indrayana Jap Lynnda Kiess Quinn Marshall Keith Martin Anuradha Narayan Mary Amuyunzu-Nayamongo Fré Pepping Keith P West 《Advances in nutrition (Bethesda, Md.)》2015,6(6):639-647
Nearly all countries in the world today are burdened with malnutrition, manifesting as undernutrition, micronutrient deficiencies, and/or overweight and obesity. Despite some progress, efforts to alleviate malnutrition are hampered by a shortage in number, skills, and geographic coverage, of a workforce for nutrition. Here, we report the findings of the Castel Gandolfo workshop, a convening of experts from diverse fields in March 2014 to consider how to develop the capacity of a global cadre of nutrition professionals for the post-2015 development era. Workshop participants identified several requirements for developing a workforce for nutrition, including an ability to work as part of a multisectoral team; communication, advocacy, and leadership skills to engage decision makers; and a set of technical skills to address future challenges for nutrition. Other opportunities were highlighted that could immediately contribute to capacity development, including the creation of a consortium to link global North and South universities, online training modules for middle managers, and practical, hands-on experiences for frontline nutrition workers. Institutional and organizational support is needed to enable workshop recommendations on education and training to be effectively implemented and sustained. The findings from the Castel Gandolfo workshop can contribute to the delivery of successful nutrition-relevant actions in the face of mounting external pressures and informing and attaining the forthcoming Sustainable Development Goals. 相似文献
73.
Brianna Lindsay Joe Oundo M. Anowar Hossain Martin Antonio Boubou Tamboura Alan W. Walker Joseph N. Paulson Julian Parkhill Richard Omore Abu S.G. Faruque Suman Kumar Das Usman N. Ikumapayi Mitchell Adeyemi Doh Sanogo Debasish Saha Samba Sow Tamer H. Farag Dilruba Nasrin Shan Li Sandra Panchalingam Myron M. Levine Karen Kotloff Laurence S. Magder Laura Hungerford Halvor Sommerfelt Mihai Pop James P. Nataro O. Colin Stine 《Emerging infectious diseases》2015,21(2):242-250
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene. 相似文献
74.
Muhammad Mohsin Hossain Md. Akherul Islam Hossain Shima Mudassir Hasan Muhammad Hilal Moonyong Lee 《RSC advances》2018,8(30):16927
Zinc acetate is recrystallized as lumber-shaped tetragonal rods by a novel recrystallization technique. Subsequently, the recrystallized zinc acetate is converted into ZnO nanorods in a glass vial by the simplest and cheapest method without utilizing any expensive instrumentation. Carbon is doped in ZnO nanorods during the preparation ZnO nanorods without any extra steps, chemicals, or effort. The carbon-doped ZnO nanorods can be dispersed in a solvent at very high concentrations and are also stable for a very long time, which are comparatively higher than those of the other existing ZnO nanoparticles. The higher dispersion concentration and higher stability of ZnO nanoparticles are explained by a scheme that demonstrates the suspending mechanism of the ZnO nanoparticles at higher concentrations with higher stabilities in a solvent through the anchoring groups of carbon. No materials are used for surface modification; no surface coatings, ionic materials, or pH controlling materials are used to increase the dispersion concentration and stability. This is the first observation of the doped carbon playing a significant role in the dispersion of ZnO nanoparticles at higher concentrations by withholding them in the solvent. Therefore, doped carbon at the surface of ZnO nanoparticles prevents the self-aggregation of ZnO nanoparticles in the solution phase by interfacial barrier layers among ZnO nanorods and interfacial interactive layer between ZnO nanorod and solvent.Dispersed ZnO hexagonal nanorods in ethanol solvent and its interfacial behavior in this liquid phase. 相似文献
75.
Nynke D Scherpbier-de Haan Gerald MM Vervoort Chris van Weel Jozé CC Braspenning Jan Mulder Jack FM Wetzels Wim JC de Grauw 《The British journal of general practice》2013,63(617):e798-e806
Background
Chronic kidney disease (CKD) is highly prevalent in patients with diabetes or hypertension in primary care. A shared care model could improve quality of care in these patientsAim
To assess the effect of a shared care model in managing patients with CKD who also have diabetes or hypertension.Design and setting
A cluster randomised controlled trial in nine general practices in The Netherlands.Method
Five practices were allocated to the shared care model and four practices to usual care for 1 year. Primary outcome was the achievement of blood pressure targets (130/80 mmHg) and lowering of blood pressure in patients with diabetes mellitus or hypertension and an estimated glomerular filtration rate (eGFR)<60ml/min/1.73m2.Results
Data of 90 intervention and 74 control patients could be analysed. Blood pressure in the intervention group decreased with 8.1 (95% CI = 4.8 to 11.3)/1.1 (95% CI = −1.0 to 3.2) compared to −0.2 (95% CI = −3.8 to 3.3)/−0.5 (95% CI = −2.9 to 1.8) in the control group. Use of lipid-lowering drugs, angiotensin-system inhibitors and vitamin D was higher in the intervention group than in the control group (73% versus 51%, 81% versus 64%, and 15% versus 1%, respectively, [P = 0.004, P = 0.01, and P = 0.002]).Conclusion
A shared care model between GP, nurse practitioner and nephrologist is beneficial in reducing systolic blood pressure in patients with CKD in primary care. 相似文献76.
77.
New abnormalities in the morphology, cell surface receptors, and electrolyte metabolism of In(Lu) erythrocytes 总被引:1,自引:0,他引:1
The In(Lu) phenotype is inherited as an autosomal dominant trait and is characterized by suppression of the Lutheran, P1, i, and Aua erythrocyte blood group antigens. We have developed a monoclonal antibody (L21) that strongly agglutinates all erythrocytes except In(Lu), and we have identified eight In(Lu) individuals among 42,000 blood donors tested. Studies of two families confirmed the dominant mode of inheritance and revealed several new features of this phenotype. The erythrocytes of all five affected individuals from the two families exhibited diminished hemagglutination by the lectin concanavalin A, although they reacted normally with several other lectins. The erythrocytes of two affected individuals in one family exhibited marked acanthocytosis. The erythrocytes of the proposita of the other family exhibited a mild degree of poikilocytosis, but the cells of the other two affected individuals in this family had normal morphology. The osmotic fragility of fresh In(Lu) erythrocytes was normal, but after incubation for 24 hours at 37 degrees C in plasma the In(Lu) cells exhibited a marked increase in resistance to osmotic lysis. During the incubation period the erythrocytes lost K+ and their total cation content was diminished. These data indicate that in addition to the suppression of blood group antigens noted previously, the In(Lu) phenotype includes a variety of morphological abnormalities and a defect in electrolyte metabolism. The use of L21 and similar monoclonal antibodies provides a more sensitive means of detecting In(Lu) erythrocytes than typing with human anti-Lub antisera. 相似文献
78.
K A Monsur M S Hossain F Huq M M Rahaman M Q Haque 《The Journal of infectious diseases》1975,131(1):40-43
A controlled study of the efficacy of cytosine arabinoside in the treatment of patients with variola major was performed. Cytosine aravinoside was given intravenously at a dose approximating 3 mg/kg of body weight every 24 hr for up to seven days. All nine patients receiving cytosine arabinoside and four of the 11 patients receiving placebo died. In three of the patients receiving cytosine aravinoside, death occurred late in the illness at a time when the patient's lesions began to dry up, the patient's temperature became normal, and the patient's general condition appeared to improve. The virus could be isolated from the blood at day 7 from three of four patients treated with cytosine arabinoside as compared with zero of six control patients. Hematologic data showed a depression in the number of circulating granulocytes. It is possible that the drug lowered the resistance to infection either through direct suppression of granulocytes or through interference with other immune mechanisms. Cytosine arabinside administered in the doses used in this study is not effective in the treatment of variola major. 相似文献
79.
80.