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991.
Rationale:Gastric adenocarcinoma of fundic gland (chief cell predominant type) (GA-FG-CCP) is a new, rare variant of gastric adenocarcinoma, which is characterized by mild nuclear atypia and specific immunohistochemical markers.Patient concerns:An 84-year-old Chinese man was referred to our hospital for endoscopic resection of a gastric lesion.Interventions:We performed endoscopic submucosal dissection, and successfully removed the lesion.Diagnosis:Esophago gastroduodenoscopy showed a slightly elevated lesion with a diameter of 22 mm in the posterior wall of cardia. Magnifying endoscopy with narrow band imaging revealed an abnormal microsurface and microvessels on the tumor surface. Endoscopic ultrasonography revealed a hypoechoic mass located in the first layer. The pathological diagnosis of the biopsy specimens indicated that the tumor was high grade intraepithelial neoplasia. The pathological diagnosis differed between the superficial and deeper part of the lesion. The superficial part was composed of a tubular structure with prominent atypia and was diagnosed as well differentiated intestinal adenocarcinoma. The deeper part was composed of a well-differentiated tubular adenocarcinoma mimicking the fundic gland cells, mainly the chief cells. The tumor cells showed mild nuclear atypia and was positive for pepsinogen-I (PG-I) and mucin-6 (MUC6). This deeper part was diagnosed as GA-FG-CCP.Outcomes:The tumor was successfully removed. This patient had no discomfort during the follow-up period (10 months).Lessons:We present a rare case of GA-FG-CCP coexisted with well-differentiated tubular adenocarcinoma. GA-FG-CCP exists in the deep mucosal layer and the muscularis mucosa, which could not be found under endoscopy, but could be discerned in pathology with mild nuclear atypia and special biomarkers. 相似文献
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Kyoung-Woo Seo Hyoung-Mo Yang Junghan Yoon Hyo-Soo Kim Kiyuk Chang Hong-Seok Lim Byoung-Joo Choi So-Yeon Choi Myeong-Ho Yoon Seung-Hwan Lee Sung Gyun Ahn Young Jin Youn Jun-Won Lee Bon-Kwon Koo Kyung Woo Park Han-Mo Yang Jung-Kyu Han Wook-Sung Chung Hun-Jun Park Byung-Hee Hwang Eun-Ho Choo Gyu-Chul Oh Seung-Jea Tahk 《Medicine》2021,100(19)
This study evaluated the 5-year clinical outcomes of the Genoss DES, the first Korean-made sirolimus-eluting coronary stent with abluminal biodegradable polymer.We previously conducted the first-in-patient prospective, multicenter, randomized trial with a 1:1 ratio of patients using the Genoss DES and Promus Element stents; the angiographic and clinical outcomes of the Genoss DES stent were comparable to those of the Promus Element stent. The primary endpoint was major adverse cardiac events (MACE), which was a composite of death, myocardial infarction (MI), and target lesion revascularization (TLR) at 5 years.We enrolled 38 patients in the Genoss DES group and 39 in the Promus Element group. Thirty-eight patients (100%) from the Genoss DES group and 38 (97.4%) from the Promus Element group were followed up at 5 years. The rates of MACE (5.3% vs 12.8%, P = .431), death (5.3% vs 10.3%, P = .675), TLR (2.6% vs 2.6%, P = 1.000), and target vessel revascularization (TVR) (7.9% vs 2.6%, P = .358) at 5 years did not differ significantly between the groups. No TLR or target vessel revascularization was reported from years 1 to 5 after the index procedure, and no MI or stent thrombosis occurred in either group during 5 years.The biodegradable polymer Genoss DES and durable polymer Promus Element stents showed comparable low rates of MACE at the 5-year clinical follow-up. 相似文献
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Lung - Recent studies have reported that ferroptosis is an iron-dependent cell death process and is a potential therapeutic target in various tumours. The purpose of this study was to establish a... 相似文献
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Chong Bryan Goh Rachel Sze Jen Kong Gwyneth Sim Faith Ruo En Ng Chen Han Teo Xin Yi Vanessa Quek Jing Xuan Lim Oliver Chin Yip Han Chan Siew-Pang Chan Mark Y. Tan Huay-Cheem Chew Nicholas W. S. Loh Poay Huan 《Journal of thrombosis and thrombolysis》2022,53(3):671-682
Journal of Thrombosis and Thrombolysis - Newer generation durable polymer drug-eluting stents (DP-DES) and biodegradable polymer DES (BP-DES) have similar efficacy with dual-antiplatelet therapy... 相似文献
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Han Thang S. Gulli Giosue Fry Christopher H. Affley Brendan Robin Jonathan Fluck David Kakar Puneet Sharma Pankaj 《Journal of thrombosis and thrombolysis》2022,53(1):218-227
Journal of Thrombosis and Thrombolysis - Complications following thrombolysis for stroke are well documented, and mostly concentrated on haemorrhage. However, the consequences of patients who... 相似文献
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Calley L. Hirsch Zeynep Coban Akdemir Li Wang Gowtham Jayakumaran Dan Trcka Alexander Weiss J. Javier Hernandez Qun Pan Hong Han Xueping Xu Zheng Xia Andrew P. Salinger Marenda Wilson Frederick Vizeacoumar Alessandro Datti Wei Li Austin J. Cooney Michelle C. Barton Benjamin J. Blencowe Jeffrey L. Wrana Sharon Y.R. Dent 《Genes & development》2015,29(12):1341