全文获取类型
收费全文 | 1542120篇 |
免费 | 101743篇 |
国内免费 | 4800篇 |
专业分类
耳鼻咽喉 | 21262篇 |
儿科学 | 46189篇 |
妇产科学 | 40054篇 |
基础医学 | 216175篇 |
口腔科学 | 41642篇 |
临床医学 | 138385篇 |
内科学 | 299002篇 |
皮肤病学 | 33254篇 |
神经病学 | 121738篇 |
特种医学 | 60634篇 |
外国民族医学 | 296篇 |
外科学 | 235141篇 |
综合类 | 32036篇 |
现状与发展 | 3篇 |
一般理论 | 474篇 |
预防医学 | 102337篇 |
眼科学 | 36711篇 |
药学 | 120961篇 |
9篇 | |
中国医学 | 4736篇 |
肿瘤学 | 97624篇 |
出版年
2021年 | 14198篇 |
2019年 | 14257篇 |
2018年 | 20024篇 |
2017年 | 15381篇 |
2016年 | 16977篇 |
2015年 | 19294篇 |
2014年 | 26764篇 |
2013年 | 37809篇 |
2012年 | 53198篇 |
2011年 | 55746篇 |
2010年 | 32561篇 |
2009年 | 30486篇 |
2008年 | 51039篇 |
2007年 | 54471篇 |
2006年 | 54507篇 |
2005年 | 52077篇 |
2004年 | 49513篇 |
2003年 | 47017篇 |
2002年 | 45092篇 |
2001年 | 78731篇 |
2000年 | 80235篇 |
1999年 | 67290篇 |
1998年 | 18687篇 |
1997年 | 16053篇 |
1996年 | 15362篇 |
1995年 | 14332篇 |
1994年 | 12853篇 |
1993年 | 12184篇 |
1992年 | 48842篇 |
1991年 | 46444篇 |
1990年 | 45384篇 |
1989年 | 43691篇 |
1988年 | 39560篇 |
1987年 | 38334篇 |
1986年 | 36069篇 |
1985年 | 33773篇 |
1984年 | 24601篇 |
1983年 | 20590篇 |
1982年 | 11775篇 |
1979年 | 21313篇 |
1978年 | 14318篇 |
1977年 | 12809篇 |
1976年 | 10924篇 |
1975年 | 12351篇 |
1974年 | 14266篇 |
1973年 | 13723篇 |
1972年 | 13024篇 |
1971年 | 12341篇 |
1970年 | 11242篇 |
1969年 | 10863篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
BackgroundWomen suffering from kidney disease are more prone to fertility problems, due to uremia. Fortunately, their fertility rate increases dramatically after renal transplantation. This study analyzes the predictors/risk factors of successful pregnancy with live birth outcome while presenting an overview of the 7-year experience of a single center.MethodsThis retrospective cohort study includes 239 women of reproductive age (18–40 years) who underwent renal transplantation in a tertiary Turkish clinic between October 1, 2011, and August 24, 2017. The subjects were invited to take part in a survey questioning their obstetric characteristics and they were assessed in 2 groups: fertile and infertile. Multivariable linear regression analysis was conducted to determine the predictors of a successful pregnancy.ResultsThirty-five 35 patients wished to become pregnant: 12 got pregnant spontaneously, while 21 failed to become pregnant (spontaneously). The mean age of the patients at the survey was 34 ± 7. Regular menstrual cycles after renal transplantation, tacrolimus-mycophenolate mofetil maintenance protocol, and age at transplantation were found to be predictors of spontaneous pregnancy. The duration of peritoneal dialysis was significantly longer in the infertile group (48 vs 12 months).ConclusionEnd-stage renal disease's negative impacts, including menstrual abnormality and fertility problems, can be overcome by successful kidney transplantation with appropriate immunosuppression. Minimizing the duration of peritoneal dialysis, particularly in patients who desire future fertility, may be accepted as a logical management strategy. 相似文献
102.
103.
104.
105.
Hend Kothayer Samy M. Ibrahim Moustafa K. Soltan Samar Rezq Shireen S. Mahmoud 《Drug development research》2019,80(3):343-352
In light of the pharmacophoric structural requirements for achieving anticonvulsant activity, a series of N-(1-methyl-4-oxo-2-un/substituted-1,2-dihydroquinazolin-3[4H]-yl)benzamide (4a-g) and N-(1-methyl-4-oxo-2-un/substituted-1,2-dihydroquinazolin-3[4H]-yl)-2-phenylacetamide (4h-n) derivatives were synthesized in two steps starting from the reaction of N-methyl isatoic anhydride with the appropriate hydrazide and followed by condensation with the appropriate aldehyde. The anticonvulsant activities of the synthesized compounds were evaluated according to the anticonvulsant drug development (ADD) programme protocol. Among the synthesized compounds, 4n showed promising activity in both the maximal electroshock (MES) and pentylenetetrazole (PTZ) tests with median effective dose (ED50) values of 40.7 and 6 mg/kg, respectively. The six most promising derivatives, 4b , 4a , 4c , 4f , 4j , and 4i , showed very low ED50 values in the PTZ test (3.1, 4.96, 8.68, 9.89, 12, and 13.53 mg/kg, respectively). All the tested compounds showed no to low neurotoxicity in the rotarod test with a wide therapeutic index. Docking studies of compound 4n suggested that GABAA binding could be the mechanism of action of these derivatives. The in silico drug likeliness parameters indicated that none of the designed compounds violate Lipinski's rule of five and that they are able to cross the blood–brain barrier.
相似文献
Hit, Lead & Candidate Discovery |
106.
107.
Jennifer Wang Jonathan G. Stine Scott L. Cornella Curtis K. Argo Steven M. Cohn 《临床与转化肝病杂志(英文版)》2015,3(4):254-259
Background and Aims: Gastric antral vascular ectasia (GAVE) is commonly found in patients with cirrhosis, but it is also associated with other diseases in the absence of cirrhosis. Whether GAVE confers a different severity of gastrointestinal (GI) bleeding between patients with and without cirrhosis remains unknown. We aim to examine whether there is a difference in clinically significant GI bleeding due to GAVE in patients with or without cirrhosis. Methods: This is a retrospective case-control study of patients who were diagnosed with GAVE between January 2000 and June 2014. Patients were categorized into cirrhosis and noncirrhosis groups, and those with an additional GI bleeding source were excluded. Univariate comparisons and multivariable models were constructed using logistic regression. Results: In total, 110 patients diagnosed with GAVE on esophagogastroduodenoscopy (EGD) were included in our analysis; 84 patients had cirrhosis (76.4%) and 26 (23.6%) did not. Active GI bleeding was more prevalent in patients without cirrhosis (63.4% vs. 32.1%, p=0.003) despite similar indications for EGD, and endoscopic treatment with argon plasma coagulation (APC) was required more often in this group, approaching statistical significance (27% vs. 10.7%, p=0.056). There was no difference in bleeding severity, as evidenced by similar re-bleeding rates, surgery, or death attributed to uncontrolled bleeding. The strongest independent risk factor for GI bleeding was the absence of cirrhosis (odds ratio (OR): 5.151 (95% confidence interval (CI): 1.08-24.48, p=0.039). Conclusions: Patients with GAVE in the absence of cirrhosis are at higher risk for active GI bleeding and require more frequent endoscopic treatment than similar patients with cirrhosis. It may be worthwhile to treat GAVE in this population even in the absence of active bleeding. 相似文献
108.
109.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse 下载免费PDF全文
110.