中心复合设计响应面法优化山茱萸山药果冻制备工艺的研究

目的 通过中心复合设计响应面法优化山茱萸山药果冻制备工艺。方法 在单因素试验基础上,采用中心复合设计正交试验。运用响应面法优化魔芋胶与卡拉胶比例、柠檬酸浓度、甜菊苷浓度和复配胶浓度4个工艺参数,并进行验证试验。结果 山茱萸山药果冻的最佳制备工艺参数为魔芋胶：卡拉胶=3.26：1,柠檬酸、甜菊苷、复配胶浓度分别为0.40%,0.10%,1.0%。结论 响应面分析法优化山茱萸山药果冻制备工艺可行。     

海洛因依赖者的脑电地形图

目的··:了解海洛因依赖者存在戒断症状时的脑电地形图的特征。方法··:用脑电图机记录32例有戒断症状的海洛因依赖者及34例正常人的脑电地形图并用计算机进行定量分析。结果·· :与对照组比较 ,海洛因依赖者 (1)慢波频段(δ、θ)功率值增高 ;(2)α1、α2 功率值减低 ;(3)快波频段(β1、β2)的枕区 (O1、O2)功率值增高。结论·· :从脑电生理角度观察海洛因对大脑功能的损害是有意义的。     

维生素D受体基因多态性对慢性血液透析患者骨代谢的影响

探讨慢性血液透析患者维生素Ｄ受体基因多态性对骨代谢的影响。方法用ＤＥＸＡ法测定了２０１例维持性血液透析患者的骨密度,用ＲＦＬＰｓ解析法分析ＶＤＲ的基因多态性,同时考察两者间的关系。     

中医药院校科技期刊助推“双一流”建设研究

[目的]探讨我国中医药院校主办的科技期刊如何助推“双一流”建设,为高等院校发展提供参考。[方法]通过分析和调查研究,首先分析“双一流”建设与中医药院校科技期刊协同发展的辩证关系;然后总结两者在协同建设中存在的突出问题,并提出整改建议;最后概括科学引文索引(Science Citation Index,SCI)源期刊的办刊现状和经验,并分析对我国中医药院校科技期刊助推“双一流”建设工作的启示。[结果]中医药院校科技期刊与“双一流”建设存在协同发展的辩证关系。目前在两者协同发展过程中,许多编辑人员对“双一流”建设内涵的理解不深刻、专业队伍综合业务素养急需提升、期刊栏目设置未完全凸显“双一流”特色、期刊政策上的支持力度急需强化、出版发行效率偏低等问题较为突出,可着重从优化期刊栏目、强化政策支持与制度建设、提升出版效率等方面予以改进。此外,国际SCI源科技期刊的办刊经验也对我国中医药院校科技期刊建设提供了启示。中医药院校SCI源科技期刊是助推“双一流”建设的重要载体,有利于推动“双一流”国际化建设,有利于提升高校基本科学指标(Essential Science Indicators,ESI)学科的影响力,有利于培养国际学术人才。[结论]中医药院校科技期刊应正视办刊的突出问题,积极整改;对标国际先进,办好期刊,高效助推“双一流”建设,以实现两者发展双赢。     

A Novel Functional Network Based on Three-way Decision for Link Prediction in Signed Social Networks

Aiming to reveal the potential relationships between users, link prediction has been considered as a fundamental research issue in signed social networks. The key of the link prediction is to measure the similarity between users. Many existing researches use connections between users and their common neighbors to measure the similarities, and these methods rely too much on the structure of social networks. Most of them use the deep neural network to enhance the prediction accuracy. However, the complete structure of the huge social network cannot be captured easily, and the models learnt by the deep neural network are unexplainable and uncontrolled. As an explainable model, functional network is a recent replacement for standard neural network. Therefore, we revise the traditional strategy of functional network and propose a novel functional network framework. Firstly, the attributes are preprocessed through the cloud model to define their importance before inputting them into the functional network. Then the association algorithm is used to do aggregate computation in computing neurons for defining the connections between neurons well. Finally, we use three-way decisions to process the samples in the boundary to optimize the performance of model. Experiments executed on six real datasets show that our method has significantly higher link prediction precision than the state-of-the-art works. From our discussions, the improved functional network can be a valid replacement for neural networks in some fields.

     

Machine Learning Modeling for Ultrasonication-Mediated Fermentation of Penicillium brevicompactum to Enhance the Release of Mycophenolic Acid

Described here is the modeling used to improve the mycophenolic acid (MPA) titer from Penicillium brevicompactum using central composite design and a comparatively newer, data-centric approach method k-nearest-neighbor algorithm. The two models for enhancing MPA production using P. brevicompactum were compared with respect to ultrasonic stimulation. During the ultrasonic treatment, we studied different independent factors such as ultrasound power, irradiation duration, treatment frequency and duty cycle to determine their ability to enhance the MPA titer value. The optimized factors such as a treatment time of 10 min (50% duty cycles) with a 12-h interlude at fixed ultrasonic power and frequency (200 W, 40 kHz) were used for ultrasonic treatment of a mycelial culture from the 2nd to 10th day of fermentation. Thus the production of MPA was improved 1.64-fold under the optimized sonication conditions compared with the non-sonicated batch fermentation (non-optimized conditions).     

儿科门诊输液处方用药分析

目的评价我院儿科门诊输液处方,以促进合理用药,保障患儿用药安全。方法采用回顾性调查方法,随机抽查我院2008年7月~2009年6月中的门诊输液处方3429张,根据临床药理学知识、药品说明书及文献资料,对输液处方中用药情况进行分类和统计分析。结果输液处方抗菌药物使用率为91.34%,联合用药比较普遍,占调查处方的86.84%;不合理用药处方共1243张,占调查处方的36.25%,多为给药方案不当、联合用药不当、用量不当等。结论输液处方中抗菌药物使用普遍,联合用药比率较高,存在不合理用药现象,合理用药水平有待进一步提高。     

No Association of the YWHAE Gene with Schizophrenia, Major Depressive Disorder or Bipolar Disorder in the Han Chinese Population

YWHAE is a gene encoding 14-3-3epsilon, which is highly conserved across species, from bacteria to humans, and binds to phosphoserine/phosphothreonine motifs in a sequence-specific manner. YWHAE has been reported to be associated with schizophrenia in a study based on the Japanese population. Here, we conducted a genetic association analysis between common SNPs in the YWHAE gene and psychiatric diseases including schizophrenia, major depressive disorder and bipolar disorder in Han Chinese samples (1140 schizophrenia cases, 1140 major depressive disorder cases, 1140 bipolar disorder cases and 1140 normal controls). We studied 11 SNPs, seven of which had previously been reported as significant, in YWHAE. No association was found with schizophrenia, major depressive disorder or bipolar disorder. Considering the size of our sample sets (power?>?90%), our results suggest that the YWHAE does not play a major role in schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population.