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71.
新生儿缺氧缺血性脑病43例临床与预后分析   总被引:3,自引:0,他引:3  
分析新生儿缺氧缺血性脑病(HIE)43例。有宫内窘迫史者占581%,出生重度窒息占814%。HIE轻度10例,中度26例,重度7例。合并心肌损害达417%。治愈好转率为813%。病死率70%。随访24例,轻度HIE预后好,中度有明显后遗症者为67%,重度预后不良。认为加强围生期保健,提高产科质量,进行新法复苏及复苏后处理是降低HIE发病率的关键。诊治中应重视心肌损害。使用胞二磷胆碱等脑细胞代谢激活剂辅治HIE效果肯定。对于预后,强调早期治疗,早期评分、早期随访、早期干预是改善重度HIE预后的几个重要环节。  相似文献   
72.
目的对郑州人民医院近3个月全肠道外营养液(TPN)处方设计进行分析,为TPN临床合理应用提供参考。方法汇总郑州人民医院近3个月TPN处方并就其配方的成分组成进行统计分析。结果郑州人民医院近3个月TPN处方669张,设计基本合理,但仍存在非蛋白热卡不足、含氮量偏低等问题,经审核排除不合格用药处方张数55张,占总处方数的8.22%。结论临床医生应针对患者的营养状况准确,合理的设计TPN配方,提高临床营养治疗的安全性和有效性,同时药师应通过审方来进一步保证处方的合理性。  相似文献   
73.
对C_4水平以下节段性颈椎后纵韧带骨化(OPLL)33例行前路骨化韧带切除术。29例随访1~10a,按JOA标准评定疗效。结果:优(术后改善率80%以上)13例;良(50%~79%)10例;改进(5%~49%)3例;无变化(5%以下)2例;加重1例,有效率89.6%。提示:C_4以下节段性OPLL适合前路开槽切除;C_4以上的节段性OPLL或连续型OPLL适合后路椎板成形椎管扩大术。充分暴露骨化灶的范围,才能将其完整切除。  相似文献   
74.
ObjectiveCraniopharyngiomas (CPs) are associated with hypothalamic damage that causes hypothalamic obesity, however, the mechanisms underlying CP-related postoperative weight gain remain debatable. This study aimed to elucidate whether the major determinant of postoperative weight gain in patients with CP is hypothalamic injury or steroid replacement therapy. MethodsWe included 48 adult patients with CP (age ≥18 years) who underwent transsphenoidal surgery between 2010 and 2018 in a single tertiary center, and whose body weight was measured pre- and postoperatively (<120 days after the surgery). We recruited 144 age- and body mass index-matched patients with non-functioning pituitary adenoma (NFPA) as controls. ResultsPatients with CP experienced greater postoperative weight gain than patients with NFPA (3.0±5.1 vs. 0.1±3.6 kg, p<0.001). The prevalence of postoperative steroid use was significantly higher in patients with CP than in those with NFPA (89.6% vs. 34.0%, p<0.001). Steroid replacement therapy and CP were associated with postoperative weight gain after adjusting for covariates in overall patients (p=0.032 and 0.007, respectively). In subgroup analysis with postoperative steroid users, weight gain was significantly greater in patients with CP (n=43, 0.96±0.25 kg/month) than in patients with NFPA (n=49, 0.26±0.23 kg/month) even after adjusting for the daily steroid dose (p=0.048). ConclusionPatients with CP experience greater postoperative weight gain than those with NFPA. Hypothalamic damage itself as well as steroid replacement may contribute to the postoperative weight gain in patients with CP.  相似文献   
75.
目的 探讨IGF-I对子宫切除所致大鼠卵巢颗粒细胞凋亡的抑制作用。方法 采用子宫切除术方法建立子宫切除Sprague-Dawley大鼠模型(保留卵巢)。向体外培养的子宫切除大鼠卵巢颗粒细胞施加60ng刖浓度外源性IGF-I。应用流式细胞仪检测细胞凋亡率。应用荧光显微镜观察细胞凋亡形态学特征。结果 模型组(子宫切除)较正常组(子宫未切除)凋亡增加;IGF-I组(子宫切除 IGF-I)能减缓子宫切除引起的凋亡升高。结论 外源性IGF-I抑制子宫切除大鼠卵巢颗粒细胞凋亡。  相似文献   
76.
We present a case of histologically confirmed lipomatous meningioma, the first to our knowledge reported in Hong Kong. A 75‐year‐old woman presented to us with on and off dizziness for 1 month. Computed tomography (CT) of the brain showed an extra‐axial mass lesion containing fat and solid enhancing foci at her right frontal region. The definitive diagnosis could be made preoperatively. Postoperative histological examination of the tumour revealed the diagnosis of lipomatous meningioma. We have reviewed the literature and discussed the diagnostic clues, clinical presentation and pathology of this rare tumour.  相似文献   
77.
This case report introduces digital surgery-first approach orthognathic surgery assisted by three-dimensional virtual planning and combined with invisible orthodontic treatment for a 21-year-old female patient with a skeletal Class III high-angle gummy smile malocclusion. We explored the clinical significance of the widespread application of digital technology for rapid development of the orthodontic/orthognathic field. The regional acceleratory phenomenon and clear aligners were used to achieve fast and aesthetic tooth movement after surgery. The treatment lasted only 8 months, and the patient was satisfied with the aesthetic results. The results remained stable after 1 year of follow-up. This case report highlights the advantages of combining a digital design and a surgery-first approach to produce accurate, rapid, safe, stable, and fulfilling cosmetic results. The combination of the surgery-first approach and clear aligners can facilitate patient-oriented surgical orthodontic treatment.  相似文献   
78.
AstudyonimprovementofexpressionofhumanG-CSFcDNAtransferredwithretroviraldouble-copyvectorGuoBaoyu(郭葆玉);ZhangSuying(张淑英);XuHui...  相似文献   
79.
BackgroundPostoperative pneumonia (PP) is the most common pulmonary complication of esophagectomy. It is of great importance to identify any high-risk factors and prevent pulmonary complications to improve the prognosis of patients with esophageal cancer undergoing esophagectomy. Thus, we established a predictive model of PP in patients with neoadjuvant immunochemotherapy for resectable esophageal squamous cell carcinoma (ESCC), and provide suggestions for the best strategy for the perioperative period of the patients.MethodWe retrospectively analyzed 78 patients who underwent esophagectomy for squamous cell carcinoma after neoadjuvant immunochemotherapy between September 2019 and August 2021.We used the “glmnet” language package in R to perform least absolute shrinkage and selection operator (LASSO) regression to screen the best predictors of PP, and nomograms predicting PP were constructed utilizing screened factors. The performance of nomograms was internally validated by calibration curves, concordance index (C-index), and the Brier score for overall performance.ResultsTwenty-six patients (33.3%) had postoperative pneumonia. After LASSO regression, the factors that were independently associated with PP were diffusing capacity of the lungs for carbon monoxide (DLCO) (P=0.0002), white blood cell (WBC) difference before vs. after neoadjuvant immunochemotherapy (P=0.0133). We constructed a prediction model, plotted the nomogram, and verified its accuracy. Its Brier score was 0.147, its calibration slope was 0.98, and its C-index was 0.85 (95% CI: 0.75–0.95). Internal validation demonstrated a good discrimination power that the actual probability corresponds closely with the predicted probability.ConclusionsOur prediction model can predict the possibility of PP in patients with neoadjuvant immunochemotherapy for resectable esophageal squamous cell carcinoma and may facilitate physicians’ efforts to reduce the incidence of postoperative pneumonia.  相似文献   
80.
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