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R. B. Gore E. A. Hadi M. Craven F. I. Smillie T. J. O'Meara† E. R. Tovey† A. Woodcock A. Custovic 《Clinical and experimental allergy》2002,32(6):856-859
BACKGROUND: Assessment of personal exposure to dust mite allergen has relied on proxy measures. Only recently has a means to directly measure inhaled allergen particle number become available (the intra-nasal air sampler). OBJECTIVE: To quantify inspired dust mite group 1 and group 2 allergen-bearing particles in bed in undisturbed conditions prior to sleep by nasal air sampling and to investigate the relationship between inhaled particles and reservoir allergen levels. METHODS: Twelve volunteers wore nasal samplers in bed for 6 evenings, nose-breathing in undisturbed conditions. Allergen-bearing particles ('halos') were detected by immunostaining for Der p 1, Der p 2, or Der p 1 and Der p 2 together, and counted by light microscopy. Count data were square root transformed for analysis of variance. Mattress dust samples were assayed for Der p 1 and Der p 2 concentrations. RESULTS: Square root detransformed mean particle counts per 30-min sample were: Der p 1, 4.22; Der p 2, 5.9; Der p 1 + Der p 2, 4.87; and for all samples, 5.01, with no difference between the groups. With replicate samples, halo number correlated significantly with mattress allergen concentrations (Der p 1 r = 0.80, P < 0.01; Der p 2 r = 0.68, P < 0.02). CONCLUSION: Nasal air sampling can be used to quantify nocturnal Der p exposure in undisturbed conditions in an area with moderate exposure to mite allergen and can provide a direct measure of inhaled mite allergen. The choice of either Der p 1 or Der p 2 is appropriate for this purpose. 相似文献
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Quantitative magnetization transfer imaging (qMTI) methods are able to estimate fundamental sample parameters, such as the relative size of the solid-like macromolecular proton pool and the spin exchange rate between this pool and the directly measured free water protons. One such method is selective inversion recovery (SIR), in which the free water protons are selectively inverted and the signal is fit to a biexponential function of the inversion time (TI). SIR uses only low-power pulses and requires no separate RF (B1) or static field (B0) field maps, and the analysis is largely independent of the macromolecular pool lineshape. These are all advantages over steady-state off-resonance saturation qMTI methods. However, up to now, SIR has been implemented only with repetition times TR>T1. This paper describes a modification of SIR with smaller TR values and a greater signal-to-noise ratio (SNR) efficiency. 相似文献
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Campath-1M--prophylactic use after kidney transplantation. A randomized controlled clinical trial 总被引:3,自引:0,他引:3
P J Friend G Hale H Waldmann S Gore S Thiru V Joysey D B Evans R Y Calne 《Transplantation》1989,48(2):248-253
Campath-1M is a rat monoclonal IgM antibody that binds human complement and recognizes virtually all peripheral human mononuclear cells. It is known to be effective in T cell depletion of bone marrow grafts, and encouraging results were obtained in a pilot study in which the antibody was used in prevention and treatment of rejection of kidney, pancreas, and liver allografts. In this randomized controlled clinical trial, Campath-1M has been evaluated as a prophylactic agent following renal allografting. It is shown that patients who received a 10-day course of the antibody immediately postoperatively, in addition to standard therapy with high-dose cyclosporine (17 mg/kg), experienced a significantly lower incidence of early acute cellular rejection than control patients who received cyclosporine alone. There was no evidence of "rebound" rejection following the end of antibody treatment to suggest that rejection had merely been delayed. However, patients who received this additional immunosuppression experienced a significantly higher incidence of serious infections than controls, this negating any benefit from the treatment in terms of graft survival. Thus, a monoclonal antibody of broad specificity directed against lymphocytes may be effective as a prophylactic agent after organ transplantation but its use should be accompanied by a reduction in other immunosuppressive drugs. 相似文献
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Roberts AD Clark SA Townsend NE Anderson ME Gore CJ Hahn AG 《European journal of applied physiology》2003,88(4-5):390-395
Nineteen well-trained cyclists (14 males and 5 females, mean initial V˙O2max 62.3 ml kg–1 min–1) completed a multistage cycle ergometer test to determine maximal mean power output in 4 min (MMPO4min), maximal oxygen uptake (V˙O2max) and maximal accumulated oxygen deficit (MAOD). The athletes were divided into three groups, each of which completed 5, 10
or 15 days of both a control condition (C) and live high:train low altitude exposure (LHTL). The C groups lived and trained
at the ambient altitude of 610 m. The LHTL groups spent 8–10 h night–1 in normobaric hypoxia at a simulated altitude of 2,650 m, and trained at the ambient altitude of 610 m. The changes to MMPO4min, V˙O2max and MAOD in response to LHTL altitude exposure were not significantly different for the 5-, 10- and 15-day treatment periods.
For the pooled data from all three treatment periods, there were significant increases in MMPO4min [mean (SD) 5.15 (0.83) W kg–1 vs 5.34 (0.78) W kg–1] and MAOD [50.1 (14.2) ml kg–1 vs 54.9 (13.1) ml kg–1] in the LHTL athletes between pre- and post-altitude exposure. There were no significant changes in MMPO4min [5.09 (0.76) W kg–1 vs 5.16 (0.86) W kg–1] or MAOD [50.5 (14.1) ml kg–1 vs 49.1 (13.0) ml kg–1] in the C athletes over the corresponding period. There were significant increases in V˙O2max in the athletes during both the LHTL [63.2 (9.0) ml kg–1 min–1 vs 64.1 (9.0) ml kg–1 min–1] and C [62.0 (8.6) ml kg–1 min–1 vs 63.4 (9.2) ml kg–1 min–1] conditions. In these athletes, there was no difference in the impact of 5, 10 or 15 days of LHTL on the increases observed
in MMPO4min, V˙O2max or MAOD; and LHTL increased MMPO4min and MAOD more than training at low altitude alone.
Electronic Publication 相似文献
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A model for susceptibility artefacts from respiration in functional echo-planar magnetic resonance imaging 总被引:1,自引:0,他引:1
Respiration causes variations in the signals acquired during magnetic resonance imaging (MRI) and therefore is a significant source of noise in functional brain imaging. A primary component of respiratory noise may arise from variations of bulk susceptibility or air volume in the chest. Here we investigate the nature of the image artefacts that can be caused by such changes. We develop a simple model which attempts to mimic the effects of variations in susceptibility and volume during respiration. Theoretical calculations, computer simulations and imaging experiments with this model show that small variations in susceptibility within the thorax from alterations in the paramagnetism of cavity gas may lead to a shift of the image on the order of 0.1 pixels as well as a shading of the intensity by +/-1%. These effects are observed to be predominant in the phase-encoding direction. They may lead to the production of spurious activations in functional MRI and are likely to be of more importance at higher field strengths. 相似文献
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