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991.
Kai Wang Xiao-tong Xu Min Jin Ao-fei Liu Bao-shi Guo Ming-yue Qu Feng Gao Li Xiang Yun-e Liu Feng-yuan Man Wei-jian Jiang 《Medicine》2022,101(50)
The basilar artery has the most perioperative complications in stenting compared to the other intracranial arteries. We aim to study whether the procedural safety in stenting for basilar stenosis has improved. This study was a single-arm, non-randomized trial that included historically controlled patients for comparison. Between January 2012 and March 2019, 147 consecutive patients with symptomatic basilar stenoses receiving elective stenting treatment were included in current basilar artery stenting (BAS) group. The prospectively collected and registered 120 patients by the same interventional team from September 2001 to November 2011 were set as historical BAS group for control. A total of 267 individuals were included in this study, with a mean age of 59.5 ± 8.1 years. The proportion of patients with lesion length >15 mm was 26.5% (39/147) in the current BAS group versus 4.2% (5/120) in the historical BAS group. We found significant differences between these 2 groups in Mori A (17.7% vs 42.5%) and Mori C patients (42.9% vs 13.3%). The proportion of patients receiving preoperative high-resolution magnetic resonance (HRMRI) evaluation was 83.0% (122/147) in the current BAS group versus 20.8% (25/120) in the historical group (P < .05). Balloon-expendable stent (BES) (n = 1), Wingspan (n = 34), and Enterprise (n = 112) stents were placed in the current BAS group. In contrast, only balloon-expendable stent (BES) (n = 48) and Wingspan (n = 72) were deployed in the historical BAS group. The incidence of the safety endpoint (SE) was 4.1% (involving 6 patients) in the current BAS group versus 11.7% (involving 14 patients) in the historical BAS group (P < .05). In multivariate analysis, no risk factor was associated with the occurrence of the safety endpoint (SE). When BAS cases operated by the surgical team accumulated to 120 to 150, the incidence of complications decreased significantly. This is the largest sample size study to discuss the safety of BAS. The significantly decreased incidence of complications indicates that the improving technical measures and the accumulation of operation experience are necessary. 相似文献
992.
993.
Degradation products of lithium oxygen batteries with a tetraethylene glycol dimethyl ether (TEGDME) electrolyte solution during discharge/charge cycles were monitored by an online cold trap pre-concentrator-gas chromatography/mass spectroscopy system in real time. A total of 37 peaks were detected and 27 of them were assigned to specific molecules. Degradation compounds were generated and decomposed in very complex manners during discharge/charge cycles. Most molecules were generated during charge as a result of the degradation of TEGDME by active oxygen species and/or electrochemical oxidation. These molecules generated during charge were decomposed during discharge by active oxygen species.Most degradation compounds of TEGDME in lithium oxygen batteries were generated during charge and molecules generated during charge were decomposed during discharge. 相似文献
994.
Xiaohan Gao Zexian Xu Shangbo Li Lidi Cheng Dian Xu Li Li Liqiang Chen Yaoxiang Xu Zijian Liu Yanshan Liu Jian Sun 《RSC advances》2023,13(6):3759
In clinical practice, challenges remain in the treatment of large infected bone defects. Bone tissue engineering scaffolds with good mechanical properties and antibiotic-controlled release are powerful strategies for infection treatment. In this study, we prepared polylactic acid (PLA)/nano-hydroxyapatite (nHA) scaffolds with vertical orthogonal and staggered orthogonal structures by applying 3D printing technology. In addition, vancomycin (Van)-based chitosan (CS) hydrogel (Gel@Van) was loaded on the scaffold (PLA/nHA/CS-Van) to form a local antibiotic release system. The microstructure of the composite scaffold had high porosity with interconnected three-dimensional networks. The mechanical properties of the PLA/nHA/CS-Van composite scaffold were enhanced by the addition of CS-Van. The results of the water contact angle analysis showed that the hydrophilicity of the drug-loaded scaffold improved. In addition, the composite scaffold could produce sustained release in vitro for more than 8 weeks without adverse effects on the proliferation and differentiation of mouse embryonic osteoblasts (MC3T3-E1), which confirmed its good biocompatibility. During the in vitro antimicrobial study, the composite scaffold effectively inhibited the growth of Staphylococcus aureus (S. aureus). Therefore, our results suggest that the PLA/nHA/CS-Van composite scaffold is a promising strategy for treating infected bone defects.The schematic diagram of preparing the composite scaffolds. 相似文献
995.
996.
目的探讨枸杞干预对代谢综合征(metabolic syndrome,MS)患者血清肿瘤坏死因子α(tumor necrosis factor,TNF-α)、核因子-κB(nuclear factor-κB,NF-κB)和诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)水平的影响。方法在横断面研究的基础上,采用病例-对照的方法,选取MS组及健康对照组各119人,比较两组间各测定指标的差异;采用随机对照的研究方法将MS组119人分为对照组和干预组,随后对干预组实施枸杞干预,运用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定两组干预0 d、干预30 d、干预45 d和干预75 d 4个时间段人群血清TNF-α、NF-κB和iNOS含量,观察枸杞的干预效果。结果代谢综合征患者血清中TNF-α、NF-κB和iNOS含量明显高于正常人(均有P<0.05);干预前后两组人群的TNF-α、NF-κB和iNOS变化有统计学差异(均有P<0.05)。结论枸杞可以抑制代谢综合征患者TNF-α、NF... 相似文献
997.
目的了解农村居民糖尿病筛查知识、态度、行为现状及其影响因素,为制订干预措施提供依据。方法采用多阶段整群随机抽样方法,抽取河北省18岁以上农村常住居民共1 041人进行问卷调查。结果 1 027例完成调查,其中男性401人,女性626人。农村居民对糖尿病慢性并发症的知晓率不足45%,对糖尿病筛查高危人群的知晓率为36.3%~76.4%。40岁以上居民3年内实际检测血糖比例为36.1%;46.2%的40岁以上居民从未检测血糖。51.7%的居民能够接受医生建议检测血糖,非常愿意了解糖尿病筛查相关知识的占58.1%,最好的途径是广播电视和医护人员宣讲。结论农村居民对糖尿病危害及糖尿病筛查高危人群的正确认知水平低,40岁以上居民主动检测血糖比例低,需要公众媒体、医护人员加强糖尿病筛查的教育;医护人员应充分利用患者就医机会,对糖尿病高危人群进行糖尿病筛查。 相似文献
998.
999.
Weiwei Tang Lihong Chen Wanxia Ma Guanjian Liu Dawei Chen Chun Wang Yun Gao Xingwu Ran 《Journal of diabetes investigation.》2023,14(1):122
Aims/IntroductionThe aim of this study was to examine the correlation between serum vitamin D concentrations and prognosis among Chinese individuals with diabetic foot ulcers (DFUs).Materials and MethodsWe retrospectively recruited 488 adults with DFUs in West China Hospital from 1 January 2012 to 31 December 2019. After telephone follow up, 275 patients were finally included. We compared serum vitamin D concentrations among DFUs patients with different prognostic status, and examined the association of vitamin D status with prognostic variables by Kaplan–Meier analysis. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals for all‐cause mortality.ResultsThe median concentration of serum vitamin D of patients with DFUs was 37.78 nmol/L (interquartile range 27.91–50.66 nmol/L), with 31.6% having vitamin D deficiency (<30 nmol/L) and 42.2% having insufficient vitamin D (<50 nmol/L). During a median follow‐up period of 52 months, 65 patients died, with an all‐cause mortality of 23.64%. Vitamin D deficiency was independently linked to increased all‐cause mortality after multivariable adjustments (hazard ratio 0.565, 95% confidence interval 0.338–0.946, P = 0.030). There were no significant differences between vitamin D concentrations and other outcomes of DFUs. Patients who suffered amputations had a tendency of lower vitamin D concentrations (34.00 [interquartile range 26.90–41.81] vs 40.21 [interquartile range 29.60–53.96] nmol/L, P = 0.053).ConclusionsVitamin D deficiency was significantly associated with increased all‐cause mortality in Chinese individuals with DFUs. Vitamin D supplementation might be a potential therapy for DFUs to prevent premature death and improve outcomes. 相似文献
1000.
Dakai Liu Yexiao Cheng Hangyu Zhou Lulan Wang Roberto Hurtado Fiel Yehudah Gruenstein Jean Jingzi Luo Vishnu Singh Eric Konadu Keither James Calvin Lui Pengcheng Gao Carl Urban Nishant Prasad Sorana Segal-Maurer Esther Wurzberger Genhong Cheng Aiping Wu William Harry Rodgers 《Emerging infectious diseases》2023,29(2):371
The Omicron variant of SARS-CoV-2 has become dominant in most countries and has raised significant global health concerns. As a global commerce center, New York, New York, USA, constantly faces the risk for multiple variant introductions of SARS-CoV-2. To elucidate the introduction and transmission of the Omicron variant in the city of New York, we created a comprehensive genomic and epidemiologic analysis of 392 Omicron virus specimens collected during November 25–December 11, 2021. We found evidence of 4 independent introductions of Omicron subclades, including the Omicron subclade BA.1.1 with defining substitution of R346K in the spike protein. The continuous genetic divergence within each Omicron subclade revealed their local community transmission and co-circulation in New York, including both household and workplace transmissions supported by epidemiologic evidence. Our study highlights the urgent need for enhanced genomic surveillance and effective response planning for better prevention and management of emerging SARS-CoV-2 variants. 相似文献