苏子油对大鼠血脂及血液流变性的影响

报告了苏子油对大鼠血清甘油三脂（ＴＧ）、总胆固醇（ＴＣ）、高密度脂蛋白（ＨＤＬ－Ｃ）、低密度脂蛋白（ＬＤＬ－Ｃ）、红细胞变形指数、血小板聚集率及ＨＤＬ－Ｃ／ＴＣ的影响。实验共分三组，猪油组、苏子油组、基础饲料组，前二组均为高脂饲料。试验期７８天。结果显示：苏子油组血ＴＣ值在试验后３０天即显著低于猪油组（Ｐ＜０．０５）。试验期末，苏子油组的ＴＣ、ＴＧ、ＬＤＬ－Ｃ均显著低于猪油组（Ｐ＜０．０５），ＴＧ值还低于基础饲料组（Ｐ＜０．０５），而ＨＤＬ－Ｃ／ＴＣ则显著高于猪油组；ＨＤＬ－Ｃ三组差别不明显（Ｐ＞０．０５）；血小板聚集率基础饲料组和苏子油组差别无意义（Ｐ＞０．０５）；但红细胞变形指数以基础饲料组最低，苏子油组其次，猪油组最高，后两组差别无意义（Ｐ＞０．０５）。提示富含α－亚麻酸的苏子油具有良好的预防和降低血脂的作用，值得进一步研究和开发。     

Protective Effect of Berberine on Cyclophosphamide‐Induced Haemorrhagic Cystitis in Rats

Abstract: The urotoxicity of cyclophosphamide and the protective effect of the herb berberine were investigated in this study. Administration of 150 mg/kg cyclophosphamide intraperitoneally caused a serious haemorrhagic cystitis in rats after 12 hr, including bladder oedema, haemorrhage, and dramatic elevation of nitric oxide metabolites (nitrite+nitrate) in urine and in plasma. To explore whether cyclophosphamide‐induced cystitis could be prevented by berberine, rats were pretreated with a single dose or two doses of berberine at 50, 100, or 200 mg/kg intraperitoneally then challenged with cyclophosphamide (150 mg/kg, intraperitoneally). The results indicated that pretreatment of rats with berberine could reduce cyclophosphamide‐induced cystitis in a dose‐dependent manner. Furthermore, we found that two doses of berberine showed greater protection against cyclophosphamide urotoxicity than when given a single dose. In addition, our data shows that a single dose of 200 mg/kg berberine, or two doses of 100, and 200 mg/kg berberine could completely block cyclophosphamide‐induced bladder oedema and haemorrhage, as well as nitric oxide metabolites increase in rat urine and plasma. In conclusion, our findings suggest that berberine could be a potential effective drug in the treatment of cyclophosphamide‐induced cystitis, and provides us with the bright hope in the prevention and treatment of cyclophosphamide urotoxicity.     

克痛喷剂的质量标准研究

采用薄层色谱法对克痛喷剂中蟾酥、冰片、大黄、栀子、白芷进行定性鉴别；并应用气相色谱法对冰片的含量进行测定。实验结果证明方法简便，斑点圆整，重现性及专属性均好，可国该制剂的质量控制标准。     

多巴酚丁胺^99m锝心肌断层显象评价冠状动脉介入性治疗的效果

用多巴酚丁胺９９ｍ锝－ＭＩＢＩ（ｍｅｔｈｏｘｙｉｓｏｂｕｔｙｌｎｉｔｒｉｌｅ）心肌断层显象（Ｄｏｂｕ－ＥＣＴ）评价冠心病介入性治疗的效果。方法对３２例冠心病患者在冠状动脉介入治疗的术前、术后３～６个月行多巴酚丁胺心肌显象。多巴酚丁胺以５～４０μｇ．ｋｇ－１／ｍｉｎ，每级剂量间隔３分钟。在最大剂量时注射７４０ＭＢｑ９９ｍ锝－ＭＩＢＩ，１小时后行心肌断层显象。２４小时后再注射等量３９９ｍ锝－ＭＩＢＩ行静态心肌显象。结果术前显示１１６个异常室壁节段，术后显示７９个节段缺血消失或缺血改善，术前心肌显象有明显可逆性心肌缺损节段，治疗有效率为７５％；而术前仅呈固定缺损节段，治疗有效率为４３．８％（Ｐ＜０．０１）。术前心脏断层显象有明显可逆心肌缺损病例，７７．８％（２１／２７）术后心肌缺血消失或改善，２２．２％（６／２７）心肌缺血无改善或缺血范围扩大，其中５例经冠状动脉造影证实原有扩张部位再狭窄。结论多巴酚丁胺９９ｍ锝－ＭＩＢＩ心肌显象可用于评价冠心病介入性治疗的效果，在随访中可发现再狭窄，进一步指导治疗     

枸橼酸抗凝血液透析

研究解剖高危出血患者血液透析的抗凝方法－局部枸橼酸抗凝的临床应用和疗效。方法：采用１．６ｍｏｌ／Ｌ的枸橼酸钠、空心纤维透析器和普通含钙碳酸氢盐透析，观察ＲＣＡ透析对患者出血、体外循环凝血、血游离钙、总钙、Ｋ＾＋，Ｎａ＾＋，ｐＨ，ＨＣＯ＾－３，Ｓｃｒ，ＢＵＮ及血清枸橼酸浓度的影响。     

胆囊结石化学类型的计算机辅助诊断

探讨胆囊结石化学类型与各影像学特征的关系，并建立简便而有效的体外预测结石化学类型的方法。     

大,巨型垂体腺瘤的手术入路选择

自１９９０年以来收治直径在２－５．６ｃｍ的大、巨型垂体腺瘤３３例。依肿瘤生长形态与扩展范围将其简略分为三种类型。Ａ型：瘤体位于鞍内或侵入蝶窦；Ｂ型；瘤体呈椭圆形或哑铃向鞍上扩展，三脑室明显移位抬高；Ｃ型：瘤体巨大侵入三脑室阻塞室间孔或明显的鞍周扩展。     

流行性出血热人群传播速度的定量研究

选取家鼠型ＥＨＦ中发病区人群血清ＥＨＦ抗体阳性率资料，试用可逆催化模型对ＥＨＦ人群传播速度进行定量研究。结果表明：所建立的可逆催化模型其理论值与实际值理论拟合较好，用χ＾２做配合适度检验，Ｐ〉０．０５。证实可逆催化模型可用来作ＥＨＦ人群中传播速度的定量研究。还发现在家鼠型ＥＨＦ疫区每１０００人中约有８０人因有效接触而获得感染，同时又有４０人血清ＥＨＦ抗体转阴。     

曲米帕明与米帕明治疗抑郁症的对比

曲米帕明（男性２０例，女性１２例；年龄３６±５１２ａ）和米帕明（男性１９例，女性１３例；年龄３８±１１ａ）治疗６４例抑郁症。开始剂量均为５０ｍｇ／ｄ，１ｗｋ内加至１５０－３００ｍｇ／ｄ，共４ｗｋ。用ＨＡＭＤ量表评定。结果显示２组抗抑郁疗效相仿。ＨＡＭＤ总分及各因子分的减分２组间无显著差异（Ｐ＞０．０５）。２组的主要不良反应为抗胆碱能症状，对心脏的影响曲米帕明似较米帕明为轻。     

A closed loop microprocessor controller for treatment of hypertension after cardiac surgery

Hypertension after cardiac surgery is common and requires accurate control by carefully regulated infusions of drugs such as sodium nitroprusside. A microprocessor-based controller has been designed to close the loop between the blood pressure response and the infusion rate of a hypotensive drug. This system has been refined by computer simulation of the blood pressure response to sodium nitroprusside and by experience gained in using the controller in eleven patients in the early recovery period after cardiac surgery. The controller was able automatically to maintain blood pressure within 10% of a specified value. Provision of sophisticated safety features in automatic drug infusion controllers is essential for patient protection.