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排序方式: 共有9105条查询结果,搜索用时 31 毫秒
71.
Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization 总被引:16,自引:0,他引:16
Guan XY Fu SB Xia JC Fang Y Sham JS Du BD Zhou H Lu S Wang BQ Lin YZ Liang Q Li XM Du B Ning XM Du JR Li P Trent JM 《Cancer Genetics and Cytogenetics》2000,123(1):27-34
Comparative genomic hybridization (CGH) has been applied to detect recurrent chromosome alterations in 62 primary gastric carcinomas. Several nonrandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11. 2-q12, 13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly observed. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and 1p (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8q23-q24.2 and 20q11.2-q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones from those regions. The gain and loss of chromosomal regions identified in this study provide candidate regions involved in gastric tumorigenesis. 相似文献
72.
73.
Autoimmunity in the pathogenesis of cardiomyopathy 总被引:3,自引:0,他引:3
74.
A new haplogroup pattern displayed in Fujian Han in China 总被引:1,自引:0,他引:1
Yu M Zhang Y Xue Y Chen F Wang Q Huang X Wang B Yu Y Liu A Ma L Shi R Lu F Shi Z Zhang Y Cheng W Ai Q Xu F Huang C Chen B Yang H Kang X Sun Y Zhang G Li P Fu S 《Journal of human genetics》2002,47(2):95-98
Human Y-chromosomal binary polymorphisms have been considered to preserve the paternal genetic legacy and provide evidence
on human evolution and the genetic relationships among and demographic history of different populations. To reveal the genetic
origin and immigration of the Fujian Han, 13 binary markers on the Y chromosome were used to screen Fujian Han by allele-specific
polymerase chain reaction. The results indicated that the M9G marker was highly prevalent (96.20%), suggesting a significant genetic drift. In addition, M122C frequency was only 22.78%, and M45A and M103T were default. The distinctive haplogroup frequencies (H1, H5, and H6/7/8) imply that the haplogroup pattern is a relatively ancestral and interim type.
Received: October 13, 2001 / Accepted: December 3, 2001 相似文献
75.
Fu W 《Zhonghua yi shi za zhi (Beijing, China : 1980)》1987,17(3):145-148
76.
THE ACTION OF RADIX REHMANNIAE AND
PLASTRUM TESTUDINIS ON BETA-
ADRENERGIC RECEPTOR-cAMP SYSTEM 总被引:1,自引:0,他引:1
Yi Ning-yu易宁育 Feng Guo-ping冯国平 Yu Yi-ming余逸明Lin Yu-zhong林育忠and Rong Zheng-xing荣征星Department of Pharmacology Shanghai Second Medical UniversityXia Zong-qin夏宗勤 Zhang Shi-de张世德 Hu Ya-er胡雅儿Isotopa Laboratory Shanghai Second Medical University Shanghai 《中华医学杂志(英文版)》1987,100(11):893-898
Mouse and rat pathological models were pro
duced by injections of thyroid hormone (T3 0r T4,
Model. I) or hydrocortisone (HC, Model II). A
single subcutaneous dose of isoproterenol (ISO)
caused plasma cAMP to peak in 5-15 min which
was significantly higher in mouse Models I and II
than in normal mice. Daily oral administration of
a decoction of two Yin tonics-Radix Rehmanniae
(RR) and Plastrum Testudinis (PT) reduced peak
cAMP in both models. 3H.DHA binding assay re
vealed significant elevations of the number of 3
adrenergic receptors in rat Models I and II. Decoc-
tion RR and PT restored the peaks to normal range.
Yang tonics Radix Aconiti praeparata (RAP) and
Cortex Cinnamomi (CC) showcd contradictory
effects on these models. It seems unlikely that the
action of the two tonics promotes the dlearance of
injected hormones, since injected hormone RIA iii
plasma showed no differences between Yin tonics
treated and untreated models. The therapeutic
effects of these two Yin tonics on "Yin deficiency"
syndrome of hyperthyroidism or hyperfunction of
the adrenal cortex is very probably related to their
actions on the O-adrenoreceptor-cAMP system as
stated. 相似文献
77.
Zheng Ying-jian郑英键and Li Qing-you李庆友Wuhan Second Municipal Hospital Wuhan 《中华医学杂志(英文版)》1986,99(3):191-194
lve cirrhotic patients underwent subtotal
splenectomy. The operative technique involved pre-
servation of anatomic segments and suture of an
omental patch to the residual spleen. With knowledge
on segmental vascular anatomy in splenomegaly, sub-
total splenic resection can be readily accomplished
with ease and safety. Follow-up of the 12 patients
showed that the preserved spleen had normal uptake
of 51Cr denatured erythrocyte isotope, high grade
serum IgM, and effect of alleviating fever after
splenectomy. Splenic scan and clinical immunologic
survey revealed the functional capacity of splenic
remnant, and the lower percentage of "pocked"
RBCs, an important clue to eusplenia. Thus, the
normal function and size retained of the residual
spleen were saved. If long-term follow-up confirms
the value of segmental splenectomy, it may become
an adjuvant treatment in lowering portal hyperten
sion in cirrhotic patients. 相似文献
78.
Zhu Xue-qing朱学清 Qian Jing-wen 钱景文Dukou First People''s Hospital Dukou Sichuan 《中华医学杂志(英文版)》1986,99(5):433-434
"Spontaneous" remission of leukemia has
been observed in both humans and animals.
Bierman et al2 in 1953 reported 11 cases of remis-
sion in acute lymphoblastic leukemia (ALL) of
childhood following acute infectious disease. In
1979 we saw a case of ALL remission in a child
following a severe attack of respiratory infection. 相似文献
79.
80.
Wang Hua Ma Xiansong :Tongji Hospital Affiliated to Tongji Medical College Huazhong U-niversity of Science Technology Wuhan Chen Yinyao : Medical School of Fudan University Shanghai Wang Liji : Department of International Cooperation Ministry of Health Beijing 《中国医院》2001,(5)
As one of the basic human rights, health is an important guarantee for productivity. The authors introduce the Andersen's behavioral model of health service use,as well as the conception and classification of access to health services based on the model. Meanwhile,the relative guidelines and the impact on the health reform of China are discussed, compared with America's and China's. This paper propounds three strategic priority of productivity development. 相似文献