全文获取类型
收费全文 | 6688篇 |
免费 | 603篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 191篇 |
妇产科学 | 149篇 |
基础医学 | 981篇 |
口腔科学 | 123篇 |
临床医学 | 733篇 |
内科学 | 1262篇 |
皮肤病学 | 90篇 |
神经病学 | 510篇 |
特种医学 | 402篇 |
外国民族医学 | 1篇 |
外科学 | 865篇 |
综合类 | 218篇 |
一般理论 | 17篇 |
预防医学 | 699篇 |
眼科学 | 134篇 |
药学 | 495篇 |
1篇 | |
中国医学 | 7篇 |
肿瘤学 | 416篇 |
出版年
2021年 | 64篇 |
2019年 | 52篇 |
2018年 | 87篇 |
2017年 | 59篇 |
2016年 | 83篇 |
2015年 | 86篇 |
2014年 | 128篇 |
2013年 | 197篇 |
2012年 | 268篇 |
2011年 | 279篇 |
2010年 | 167篇 |
2009年 | 135篇 |
2008年 | 248篇 |
2007年 | 283篇 |
2006年 | 254篇 |
2005年 | 258篇 |
2004年 | 276篇 |
2003年 | 215篇 |
2002年 | 268篇 |
2001年 | 243篇 |
2000年 | 255篇 |
1999年 | 201篇 |
1998年 | 111篇 |
1997年 | 94篇 |
1996年 | 90篇 |
1995年 | 85篇 |
1994年 | 89篇 |
1993年 | 74篇 |
1992年 | 197篇 |
1991年 | 180篇 |
1990年 | 169篇 |
1989年 | 130篇 |
1988年 | 156篇 |
1987年 | 154篇 |
1986年 | 175篇 |
1985年 | 131篇 |
1984年 | 102篇 |
1983年 | 85篇 |
1982年 | 65篇 |
1979年 | 74篇 |
1978年 | 51篇 |
1976年 | 55篇 |
1975年 | 50篇 |
1974年 | 55篇 |
1973年 | 73篇 |
1972年 | 53篇 |
1971年 | 62篇 |
1970年 | 54篇 |
1969年 | 70篇 |
1968年 | 56篇 |
排序方式: 共有7344条查询结果,搜索用时 15 毫秒
21.
Reductions in depressed mood and denial coping during cognitive behavioral stress management with hiv-positive gay men treated with haart 总被引:1,自引:1,他引:0
Adam W. Carrico M.S. Michael H. Antoni Ph.D. Ron E. Durán Ph.D. Gail Ironson M.D. Ph.D. Frank Penedo Ph.D. Mary Ann Fletcher Ph.D. Nancy Klimas M.D. Neil Schneiderman Ph.D. 《Annals of behavioral medicine》2006,31(2):155-164
Background: Stress management interventions for HIV-positive persons have been designed to enhance coping skills and encourage health-promoting
behaviors with the hope of decreasing distress and slowing disease progression.Purpose: We examined the efficacy of a cognitive behavioral stress management (CBSM) intervention in combination with medication
adherence training (MAT) in 130 gay and bisexual men living with HIV infection.Methods: Participants were randomized to either a 10-week CBSM+MAT intervention (n = 76) or a MAT-only condition (n = 54). Measures
of self-reported adherence, active cognitive coping (i.e., acceptance and positive reinterpretation), avoidant coping (i.e.,
denial and behavioral disengagement), and depressed mood were examined over the 10-week intervention period.Results: Men in CBSM+MAT reported reductions in depressed mood and denial coping during the 10-week intervention period, but no changes
in active cognitive coping or self-reported adherence were observed. Using path analysis, greater reliance on denial coping
at baseline was associated with decreased depressed mood at 10 weeks. We also determined that CBSM+MAT may decrease depressed
mood by reducing reliance on denial coping over the 10-week intervention period.Conclusions: Although denial may be an effective means of distress reduction in the short term, reliance on this coping strategy may
result in a decreased capacity to effectively manage a variety of disease-related stressors in the long term. CBSM+MAT addresses
this potentially detrimental pattern by teaching stress reduction skills that may decrease depressed mood via reduced reliance
on denial coping.
This research was supported by National Institute of Mental Health Grants P01 MH49548 and T32 MH18917. 相似文献
22.
Anulus fibrosus in bulging intervertebral disks 总被引:1,自引:0,他引:1
In this investigation the association of radial tears of the anulus fibrosus and bulging of the intervertebral disk was studied. An index of disk bulging was measured in sagittal anatomic sections in 149 lumbar disks from 31 cadavers. The indexes of disk bulging were correlated with stages of disk development and the presence of an annular tear. The largest disk-bulging indexes were always associated with radial tears of the anulus. Eighty-four percent of the disks with radial tears had disk-bulging indexes greater than 2.5 mm. Most normal adult disks had an index of less than 2.5 mm. The results challenge the concept that the anulus fibrosus is intact in bulging disks, although ruptured in herniated disks. 相似文献
23.
Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders. 总被引:20,自引:0,他引:20
J Kabat-Zinn A O Massion J Kristeller L G Peterson K E Fletcher L Pbert W R Lenderking S F Santorelli 《The American journal of psychiatry》1992,149(7):936-943
OBJECTIVE: This study was designed to determine the effectiveness of a group stress reduction program based on mindfulness meditation for patients with anxiety disorders. METHOD: The 22 study participants were screened with a structured clinical interview and found to meet the DSM-III-R criteria for generalized anxiety disorder or panic disorder with or without agoraphobia. Assessments, including self-ratings and therapists' ratings, were obtained weekly before and during the meditation-based stress reduction and relaxation program and monthly during the 3-month follow-up period. RESULTS: Repeated measures analyses of variance documented significant reductions in anxiety and depression scores after treatment for 20 of the subjects--changes that were maintained at follow-up. The number of subjects experiencing panic symptoms was also substantially reduced. A comparison of the study subjects with a group of nonstudy participants in the program who met the initial screening criteria for entry into the study showed that both groups achieved similar reductions in anxiety scores on the SCL-90-R and on the Medical Symptom Checklist, suggesting generalizability of the study findings. CONCLUSIONS: A group mindfulness meditation training program can effectively reduce symptoms of anxiety and panic and can help maintain these reductions in patients with generalized anxiety disorder, panic disorder, or panic disorder with agoraphobia. 相似文献
24.
J Staessen A Amery W Birkenh?ger C J Bulpitt J Cox P de Leeuw P De Cort R Fagard A Fletcher F Forette 《Journal of cardiovascular pharmacology》1992,19(1):120-125
Syst-Eur is a multicenter placebo-controlled outcome trial designed by the European Working Party on High Blood Pressure in the Elderly to investigate the effect of antihypertensive treatment on the incidence of stroke in elderly patients with isolated systolic hypertension (ISH). Eligible patients must be at least 60 years old and have a systolic blood pressure averaging 160-219 mm Hg with a diastolic blood pressure less than 95 mm Hg. The present paper is an interim report on the first 316 patients randomized into this trial. The placebo (n = 170) and active treatment (n = 146) groups were similar at randomization with respect to age (73 +/- 8 years; mean +/- SD), sitting blood pressure (178 +/- 12 mm Hg systolic; 85 +/- 7 mm Hg diastolic), percentage of men (34%), and percentage of patients with cardiovascular complications (29%). After randomization blood pressure fell more (p less than 0.001) in patients on active treatment than in those in the placebo group (19 +/- 20 mm Hg systolic; 6 +/- 10 mm Hg diastolic vs. 7 +/- 19 and 1 +/- 10 mm Hg for sitting blood pressure). This first interim report on the Syst-Eur trial demonstrates that a multinational trial in elderly patients with ISH is feasible and that a significant blood pressure difference between the two treatment groups can be achieved and maintained. New centers are being recruited in order to randomize a total of 3,000 patients. 相似文献
25.
Jeffrey E. Fletcher Florence J. Huggins Henry Rosenberg 《Journal canadien d'anesthésie》1990,37(6):695-698
Intracellular Ca++ levels in skeletal muscle are elevated during the in vitro contracture response of muscle from subjects with malignant hyperthermia. The role of Ca++ in the bathing medium and the consequences of substitution of Sr++ for Ca++ in the response to agents associated with malignant hyperthermia were examined. When Ca++ was omitted from the bathing medium the contractures induced in human vastus lateralis by halothane (three per cent) or succinylcholine (50 mM) were reduced by 80 and 100 per cent, respectively, while contractures induced by caffeine (8 mM) were only reduced by 50 per cent. Substitution of Ca++ by another divalent cation, Sr++, completely restored contractures induced by caffeine, but only partially restored contractures induced by halothane or succinylcholine (to 50 and 30 per cent of Ca(++)-containing medium, respectively). Mepacrine (10 microM) was effective in antagonizing contractures by caffeine, whereas verapamil and nifedipine (10 microM) were not. These results support an essential role for extracellular Ca++ not fulfilled by Sr++ in contracture induction by halothane and succinylcholine, but not by caffeine. 相似文献
26.
27.
28.
Urologists remain divided as to the need for routine irrigation following transurethral prostatectomy (TURP). This randomised prospective study compared a policy of irrigation with that of no irrigation in a consecutive group of 200 patients undergoing TURP. In the irrigation group, a mean of 15 litres of irrigating fluid was used in each patient and one-third of patients required at least one bladder washout. In the no irrigation group, although two-thirds of the patients required at least one bladder washout, only one-third required more than one washout. No significant difference in blood loss, electrolyte balance, infection rate or recovery was seen in the 2 groups. This study led to a local change in practice, converting from a policy of routine irrigation to one of no irrigation. 相似文献
29.
30.
Susan Miesfeldt Christine Hayden Netta Apedoe Sharon Jerome Andrea Fletcher 《Journal of community health》2010,35(2):109-114
Over 800 Maine residents will be diagnosed with colorectal cancer (CRC) this year, and nearly 300 will die from the disease.
While CRC screening can reduce these rates, it is only among insured populations that screening rates exceed 50%. This project
aimed to reduce barriers to, and increase rates of CRC screening among underinsured and uninsured women, ages 50 years and
over, residing in Cumberland County, Maine. The existing network of the Maine Breast and Cervical Health Program (MBCHP) was
used to reach the target population. A packet containing (1) an offer for no-cost fecal occult blood test (FOBT) screening
and CRC-related educational materials, and (2) a stamped, addressed postcard specifying the woman’s interest in these resources,
was mailed to 300 MBCHP enrollees residing in Cumberland County. Women requesting screening were contacted by phone to further
determine eligibility. Ninety-three women (31%) requested FOBT kits and 29 of these women requested educational materials.
Ten women were ineligible for screening because of previous colonoscopy. Fifty-two completed FOBT kits (63%) were returned;
all were negative. An additional 42 (14%) women requested educational materials only. To reduce the burden of CRC in Maine
and nationally, disparate populations must be reached with efficient and effective screening services. Established networks
are proven means for reaching uninsured and underinsured individuals with education, screening services, and necessary follow-up
care. This project serves as a model for the future development of similar programs statewide and nationally. 相似文献