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951.
Jacqueline de Carvalho Martins Suzana Sales Aguiar Erica Alves Nogueira Fabro Rejane Medeiros Costa Thiago Vilela Lemos Vinicius Gienbinsky Guapyassú de Sá Raphael Mello de Abreu Mauro Figueiredo Carvalho de Andrade Luiz Claudio Santos Thuler Anke Bergmann 《Supportive care in cancer》2016,24(3):1119-1124
Purpose
The aim of this study is to assess the safety and tolerability of Kinesio® Taping (KT) in patients with arm lymphedema.Method
Medical device clinical study in women with arm lymphedema. Kinesio® Tex Gold bandage was applied by the KT technique. Assessments and interviews were carried out both at the beginning and 4 days after intervention. Skin disorders, reported tolerance and modification of limb volume and function after intervention were assessed. Changes in limb volume and functionality before and after intervention were compared by the Student’s t test and the Wilcoxon Signed-Rank test, considering significant p value <0.05.Results
Twenty-four women were studied. After intervention, no patient had cutaneous lesions, vesicle or limb hyperthermia, and 4.2 % presented skin peeling and redness. Most patients reported no change in social life and that they felt safer in the daily activity and were very pleased with the treatment. The patients presented improvement of upper limb functionality after intervention (p?<?0.001). No difference of limb volume was found after intervention (p?=?0.639).Conclusions
Kinesio® Tex Gold bandage by the KT technique proved to be safe and tolerable in patients with lymphedema, with improved functionality and no change of the affected limb volume.952.
In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist 总被引:3,自引:0,他引:3
D W Snyder R E Giles R A Keith Y K Yee R D Krell 《The Journal of pharmacology and experimental therapeutics》1987,243(2):548-556
ICI 198,615 is a representative compound from a new class of peptide leukotriene (LT) receptor antagonists. In isolated guinea pig trachea and parenchymal lung strips, ICI 198,615 demonstrated competitive antagonism of the contractile activity of LTD4 and LTE4 with pA2 values of 10.1 to 9.5, respectively. The compound also appeared to antagonize the contractile activity of LTC4 in guinea pig trachea; however, in the presence of an inhibitor of the metabolism of LTC4 to LTD4, ICI 198, 615 provided a pKB value of 5.3, indicating weak antagonism at the LTC4 receptor. ICI 198,615 was also a potent antagonist of LTC4 and LTD4 in isolated human bronchi and pulmonary veins with pKa values of 9.75 +/- 0.32 to 9.20 +/- 0.24, respectively. When evaluated for activity on a broad variety of non-LT receptors, the compound displayed a minimal selectivity of 6310 and a maximal selectivity of greater than 125,000 for the LTE4 receptor. These in vitro studies indicate that ICI 198,615 is the most potent and selective peptide LT receptor antagonist described to date. 相似文献
953.
G C Yee W R Crom F H Lee R D Smyth W E Evans 《Clinical pharmacology and therapeutics》1983,33(5):668-673
Bleomycin kinetics were determined in 14 children after intravenous bolus and prolonged infusion doses. Plasma and urine bleomycin concentrations were determined by radioimmunoassay. After intravenous bolus, bleomycin concentrations were adequately described by a two-compartment open model with a mean t1/2 alpha and t1/2 beta of 0.3 +/- 0.1 and 3.2 +/- 0.7 hr (mean +/- SEM). Volume of the central compartment and volume of distribution at steady-state (Vss) were 4.3 +/- 0.5 and 9.9 +/- 1.1 l/m2. Total plasma (CLT) and renal (CLR) clearance were 51.8 +/- 6.1 and 33.5 +/- 2.4 ml/min/m2. Three intravenous bolus courses were given to two patients who received more than four courses of cisplatin (greater than 300 mg/m2); CLT and CLR for these courses were 18.0 +/- 3.3 and 8.2 ml/min/m2. Conversely, children under 3 yr old eliminated bleomycin more rapidly than older children. Decline in bleomycin concentrations after seven 24- or 48-hr intravenous infusions was described by a one-compartment model. Mean values for plasma t1/2, Vss, CLT, and CLR were 2.1 +/- 0.1 hr, 11.0 +/- 2.6 l/m2, 57.1 +/- 13.5 ml/min/m2, and 33.2 +/- 6.4 ml/min/m2. One patient received his bleomycin infusion when ureteral obstruction was present; CLT and CLR for this course were 4.8 and 4.1 ml/min/m2. These data indicate that young children eliminate bleomycin more rapidly than older children and that children with impaired renal function may have prolonged elevations in plasma concentration due to reduced bleomycin clearance. Bleomycin disposition in older children is as in adults. 相似文献
954.
Effect of a hospital-associated urinary tract infection reduction policy on general surgery patients
Sheena K. Harris Erica L. Mitchell Michael R. Lasarev Fouad Attia John G. Hunter Brett C. Sheppard 《American journal of surgery》2018,215(4):658-662
Background
Hospital-associated UTI rates in surgery patients have not improved despite recommendations for reducing indwelling catheter days.Methods
We performed a retrospective review of institutional NSQIP general surgery patient data, 2006–2015. During this time, a UTI-reduction policy was implemented. Demographics, HA-UTI incidence, CA-UTI incidence, indwelling catheter days, straight catheterization rates, and mortality were examined.Results
Females had significantly higher risk of HA-UTI. There was no significant change in HA-UTI (X12?=?0.02, p?=?.878) or indwelling catheter days (5.18?±?1.12 days v 3.73?±?0.39 days, p?=?.23). Straight catheterizations among those with HA-UTI increased (0.04?±?0.04 v 0.32?±?0.12, p?=?.029). There was no change in CA-UTI (1.38 v 1.11 CAUTI/1000 patient hospital-days P?=?.555) or in initial indwelling catheter days of patients with CA-UTI (7.2 SD 8.89 v 47.0 SD 7.04 days P?=?.961) after policy implementation.Conclusions
The reduction policy increased the number of straight catheterizations for patients developing HA-UTI, but did not reduce the number of initial indwelling catheter days, HA-UTI rates, or CA-UTI rates. 相似文献955.
The nutritional knowledge of Australian nurses 总被引:3,自引:0,他引:3
956.
957.
958.
Expanding the fetal phenotype: Prenatal sonographic findings and perinatal outcomes in a cohort of patients with a confirmed 22q11.2 deletion syndrome
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Erica Schindewolf Nahla Khalek Mark P. Johnson Juliana Gebb Beverly Coleman Terrence Blaine Crowley Elaine H. Zackai Donna M. McDonald‐McGinn Julie S. Moldenhauer 《American journal of medical genetics. Part A》2018,176(8):1735-1741
22q deletion syndrome (22q11.2DS) is most often correlated prenatally with congenital heart disease and or cleft palate. The extracardiac fetal phenotype associated with 22q11.2DS is not well described. We sought to review both the fetal cardiac and extracardiac findings associated with a cohort of cases ascertained prenatally, confirmed or suspected to have 22q11.2DS, born and cared for in one center. A retrospective chart review was performed on a total of 42 cases with confirmed 22q11.2DS to obtain prenatal findings, perinatal outcomes and diagnostic confirmation. The diagnosis was confirmed prenatally in 67% (28/42) and postnatally in 33% (14/42). The majority (81%) were associated with the standard LCR22A‐LCR22D deletion. 95% (40/42) of fetuses were prenatally diagnosed with congenital heart disease. Extracardiac findings were noted in 90% (38/42) of cases. Additional findings involved the central nervous system (38%), gastrointestinal (14%), genitourinary (16.6%), pulmonary (7%), skeletal (19%), facial dysmorphism (21%), small/hypoplastic thymus (26%), and polyhydramnios (30%). One patient was diagnosed prenatally with a bilateral cleft lip and cleft palate. No fetus was diagnosed with intrauterine growth restriction. The average gestational age at delivery was 38 weeks and average birth weight was 3,105 grams. Sixty‐two percentage were delivered vaginally and there were no fetal demises. A diagnosis of 22q11.2 deletion syndrome should be considered in all cases of prenatally diagnosed congenital heart disease, particularly when it is not isolated. Microarray is warranted in all cases of structural abnormalities diagnosed prenatally. Prenatal diagnosis of 22q11.2 syndrome can be used to counsel expectant parents regarding pregnancy outcome and guide neonatal management. 相似文献
959.
Radiofrequency ablation of atrial flutter: a randomized controlled study of two anatomic approaches 总被引:1,自引:0,他引:1
Passman RS Kadish AH Dibs SR Engelstein ED Goldberger JJ 《Pacing and clinical electrophysiology : PACE》2004,27(1):83-88
Atrial flutter often results from a macroreentrant circuit that uses anatomic structures within the right atrium as its borders. RF ablation at the site of an obligatory isthmus can eliminate the atrial flutter circuit. The aim of this study was to compare two approaches to atrial flutter ablation: the septal (septal aspect of the tricuspid valve annulus to coronary sinus ostium and Eustachian ridge) approach versus the posterior (inferior vena cava to tricuspid valve annulus) approach. Twenty patients were randomized to either the "septal" or "posterior" approach. Entrainment mapping and/or confirmation of bidirectional isthmus conduction at baseline were performed in those patients in atrial flutter and normal sinus rhythm, respectively. RF ablation was performed with standard catheters and techniques. Crossover was permitted after two lines of RF lesions. Endpoints included acute success rates and fluoroscopy times. There was no statistically significant difference in the success rate between the two approaches using intention-to-treat analysis. Fluoroscopy times in the septal versus posterior approaches were 58.4 +/- 30.3 versus 70.8 +/- 31.1 minutes, respectively (P = 0.7). There was more frequent crossover in patients assigned to the septal approach and the one major complication, atrioventricular block, also occurred using this approach. There was no statistically significant difference in the success rate or fluoroscopy times between the septal and posterior approaches to atrial flutter ablation. However, given the risk of atrioventricular block with the septal approach, the posterior approach should be the preferred initial choice. 相似文献
960.
Yannick Simoni Michael Fehlings Henrik N. Kløverpris Naomi McGovern Si-Lin Koo Chiew Yee Loh Shawn Lim Ayako Kurioka Joannah R. Fergusson Choong-Leong Tang Ming Hian Kam Koh Dennis Tony Kiat Hon Lim Alexander Chung Yaw Fui Chan Weng Hoong Jerry Kok Yen Chan Maria Curotto de Lafaille Sriram Narayanan Evan W. Newell 《Immunity》2018,48(5):1060