全文获取类型
收费全文 | 53039篇 |
免费 | 3684篇 |
国内免费 | 179篇 |
专业分类
耳鼻咽喉 | 601篇 |
儿科学 | 1070篇 |
妇产科学 | 792篇 |
基础医学 | 6798篇 |
口腔科学 | 693篇 |
临床医学 | 4901篇 |
内科学 | 12868篇 |
皮肤病学 | 532篇 |
神经病学 | 5200篇 |
特种医学 | 2100篇 |
外科学 | 8471篇 |
综合类 | 588篇 |
一般理论 | 65篇 |
预防医学 | 3663篇 |
眼科学 | 926篇 |
药学 | 3193篇 |
中国医学 | 49篇 |
肿瘤学 | 4392篇 |
出版年
2024年 | 42篇 |
2023年 | 286篇 |
2022年 | 601篇 |
2021年 | 1434篇 |
2020年 | 900篇 |
2019年 | 1296篇 |
2018年 | 1642篇 |
2017年 | 1118篇 |
2016年 | 1204篇 |
2015年 | 1441篇 |
2014年 | 2164篇 |
2013年 | 2510篇 |
2012年 | 4325篇 |
2011年 | 4293篇 |
2010年 | 2403篇 |
2009年 | 2150篇 |
2008年 | 3756篇 |
2007年 | 3865篇 |
2006年 | 3743篇 |
2005年 | 3685篇 |
2004年 | 3287篇 |
2003年 | 3027篇 |
2002年 | 2740篇 |
2001年 | 320篇 |
2000年 | 227篇 |
1999年 | 329篇 |
1998年 | 490篇 |
1997年 | 442篇 |
1996年 | 357篇 |
1995年 | 324篇 |
1994年 | 253篇 |
1993年 | 237篇 |
1992年 | 143篇 |
1991年 | 129篇 |
1990年 | 117篇 |
1989年 | 95篇 |
1988年 | 89篇 |
1987年 | 69篇 |
1986年 | 75篇 |
1985年 | 100篇 |
1984年 | 121篇 |
1983年 | 106篇 |
1982年 | 137篇 |
1981年 | 109篇 |
1980年 | 96篇 |
1979年 | 42篇 |
1978年 | 61篇 |
1977年 | 58篇 |
1976年 | 49篇 |
1975年 | 41篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
Anesthesia for subcutaneous implantable cardioverter‐defibrillator implantation: Perspectives from the clinical experience of a U.S. panel of physicians 下载免费PDF全文
Michael K. Essandoh MD George E. Mark MD Johan D. Aasbo DO Charles A Joyner MD Saumya Sharma MD Beningo F Decena MD Eric D Bolin MD Raul Weiss MD Martin C Burke DO Timothy R. McClernon PhD Emile G. Daoud MD Michael R. Gold MD PhD 《Pacing and clinical electrophysiology : PACE》2018,41(7):807-816
1 Background and objective
Worldwide adoption of the subcutaneous implantable cardioverter‐defibrillator (S‐ICD) for preventing sudden cardiac death continues to increase, as longer‐term evidence demonstrating the safety and efficacy of the S‐ICD expands. As a relatively new technology, comprehensive anesthesia guidance for the management of patients undergoing S‐ICD placement is lacking. This article presents advantages and disadvantages of different periprocedural sedation and anesthesia options for S‐ICD implants including general anesthesia, monitored anesthesia care, regional anesthesia, and nonanesthesia personnel administered sedation and analgesia.2 Methods
Guidance, for approaches to anesthesia care during S‐ICD implantation, is presented based upon literature review and consensus of a panel of high‐volume S‐ICD implanters, a regional anesthesiologist, and a cardiothoracic anesthesiologist with significant S‐ICD experience. The panel developed suggested actions for perioperative sedation, anesthesia, surgical practices, and a decision algorithm for S‐ICD implantation.3 Conclusions
While S‐ICD implantation currently requires higher sedation than transvenous ICD systems, the panel consensus is that general anesthesia is not required or is obligatory for the majority of patients for the experienced S‐ICD implanter. The focus of the implanting physician and the anesthesia services should be to maximize patient comfort and take into consideration patient‐specific comorbidities, with a low threshold to consult the anesthesiology team. 相似文献992.
Purpose
Morphine ARER is a novel oral, abuse-deterrent, extended-release (ER) formulation of morphine sulfate with physical and chemical properties that deter misuse and abuse by nonoral routes of administration. Here we evaluate the relative bioavailability of morphine ARER and extended-release morphine.Methods
This single-dose, 2-treatment, 2-period, 2-sequence, randomized crossover study in healthy adult subjects compared the relative bioavailability of morphine ARER 100 mg to that of ER morphine 100 mg in the fasted condition. At 12 and 1.5 hours before dosing and 12 hours after dosing, all subjects received a 50-mg oral naltrexone tablet to minimize opioid-related side effects. Pharmacokinetic parameters including the AUC0–t, AUC0–∞, and Cmax of morphine and its metabolite morphine-6-glucuronide (M6G) were determined at various times up to 48 hours postdose. The bioequivalence of morphine ARER and ER morphine was determined using an ANOVA of the least-squares mean values of morphine and M6G bioavailability.Findings
Forty-nine subjects completed the study. Both morphine ARER and ER morphine exhibited peak plasma morphine and M6G concentrations of ~30 ng/mL and ~200 ng/mL, respectively, at 3 hours postdose. The 90% CIs of the ln-transformed values of morphine AUC0–t, AUC0–∞, and Cmax were within the 80% to 125% range for bioequivalence. M6G values also indicated bioequivalence of morphine ARER and ER morphine. The most common adverse events were nausea and somnolence.Implications
These data show that, in these subjects, morphine ARER was bioequivalent to ER morphine, a treatment for pain with well-established efficacy and safety profiles. 相似文献993.
Janet Prvu Bettger Vu Q.C. Nguyen J. George Thomas Tami Guerrier Qing Yang Mark A. Hirsch Terrence Pugh Gabrielle Harris Mary Ann Eller Carol Pereira Deanna Hamm Eric A. Rinehardt Matthew Shall Janet P. Niemeier 《Archives of physical medicine and rehabilitation》2018,99(6):1226-1231
Attention to health care quality and safety has increased dramatically. The internal focus of an organization is not without influence from external policy and research findings. Compared with other specialties, efforts to align and advance rehabilitation research, practice, and policy using electronic health record data are in the early stages. This special communication defines quality, applies the dimensions of quality to rehabilitation, and illustrates the feasibility and utility of electronic health record data for research on rehabilitation care quality and outcomes. Using data generated at the point of care provides the greatest opportunity for improving the quality of health care, producing generalizable evidence to inform policy and practice, and ultimately benefiting the health of the populations served. 相似文献
994.
995.
996.
A randomized trial using telehealth technology to link caregivers with dementia care experts for in‐home caregiving support: FamTechCare protocol 下载免费PDF全文
997.
998.
Shadi Lahham Brent A. Becker Abdulatif Gari Steven Bunch Maili Alvarado Craig L. Anderson Eric Viquez Sophia C. Spann John C. Fox 《The American journal of emergency medicine》2018,36(6):962-966
Background
Measurement of the common bile duct (CBD) is considered a fundamental component of biliary point-of-care ultrasound (POCUS), but can be technically challenging.Objective
The primary objective of this study was to determine whether CBD diameter contributes to the diagnosis of complicated biliary pathology in emergency department (ED) patients with normal laboratory values and no abnormal biliary POCUS findings aside from cholelithiasis.Methods
We performed a prospective, observational study of adult ED patients undergoing POCUS of the right upper quadrant (RUQ) and serum laboratory studies for suspected biliary pathology. The primary outcome was complicated biliary pathology occurring in the setting of normal laboratory values and a POCUS demonstrating the absence of gallbladder wall thickening (GWT), pericholecystic fluid (PCF) and sonographic Murphy's sign (SMS). The association between CBD dilation and complicated biliary pathology was assessed using logistic regression to control for other factors, including laboratory findings, cholelithiasis and other sonographic abnormalities.Results
A total of 158 patients were included in the study. 76 (48.1%) received non-biliary diagnoses and 82 (51.9%) were diagnosed with biliary pathology. Complicated biliary pathology was diagnosed in 39 patients. Sensitivity of CBD dilation for complicated biliary pathology was 23.7% and specificity was 77.9%.Conclusion
Of patients diagnosed with biliary pathology, none had isolated CBD dilatation. In the absence of abnormal laboratory values and GWT, PCF or SMS on POCUS, obtaining a CBD measurement is unlikely to contribute to the evaluation of this patient population. 相似文献999.
Lisa Mills Eric J. Morley Zachary Soucy Gary M. Vilke Samuel H.F. Lam 《The Journal of emergency medicine》2018,54(2):215-220
Background
This review provides practicing emergency physicians updated information regarding point-of-care ultrasound (POCUS) imaging of patients with suspected urolithiasis.Methods
A PubMed literature search was conducted for articles published between January 1, 1996 and May 31, 2017 and limited to human clinical trials written in English with relevant keywords. High-quality studies identified then underwent a structured review. Recommendations herein are made based on the literature review.Results
Two hundred seventy-two abstracts fulfilling the search criteria were screened and 10 appropriate articles were rigorously reviewed in detail. There were 8 prospective studies and 2 retrospective studies. Only 1 of them was a multi-institutional randomized trial. POCUS performed in the emergency department (ED) is moderately sensitive and specific in making the diagnosis of urolithiasis in symptomatic patients. Suspected urolithiasis patients evaluated initially with ED POCUS have complication rates compatible with those evaluated initially with computed tomography.Conclusions
POCUS has moderate accuracy in making the diagnosis of urolithiasis. Nevertheless, it may be safely used as a first line of imaging in ED patients with suspected symptomatic urolithiaisis. 相似文献1000.
Disaster Training in 24 Hours: Evaluation of a Novel Medical Student Curriculum in Disaster Medicine
Lauren Wiesner Shane Kappler Alex Shuster Michael DeLuca James Ott Eric Glasser 《The Journal of emergency medicine》2018,54(3):348-353