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61.
62.
Dr. Egon Fauvet 《Journal of molecular medicine (Berlin, Germany)》1929,8(43):2004-2006
Zusammenfassung Die Aktivmethoden nach.Bruck, Kadisch und Tsü wurden einer Nachprüfung unterzogen. Die Kadischsche Reaktion hatte bei 500 Fällen eine Unbrauchbarkeitsziffer von 39 %. Wir halten sie deswegen und wegen ihrer nicht unkomplizierten Technik für nicht geeignet, um in der täglichen Praxis Anwendung zu finden.Die Tsüsche Reaktion — an 322 Fällen nachgeprüft — ergab in 7.08 % Ausfälle durch unspezifische oder Eigenhemmung.Bei einer Gegenüberstellung zu der Bruckschen Reaktion ergab sich eine Überlegenheit von 2,49% der letzteren.Die Nachprüfung der Bruckschen Methode an 600 Seren ergab gegenüber der Inaktivmethode nachWassermann 5,33% Ausfälle durch unspezifische oder Eigenhemmung und hinsichtlich der Schärfe eine Überlegenheit von 2,5%.Die Anwendung der BR. als Zusatzmethode ist angängig; ein Verzicht auf die WaR. nach dem Vorschlag vonBruck wird aber abgelehnt, da einmal die Schärfe der BR. auf Kosten der Spezifität erkauft werden muß, andererseits die Erhöhung der spezifischen Schärfe der WaR. im Bereich der Möglichkeiten liegt, und endlich die Anwendung der BR. nicht in allen Fällen (alte Seren, Liquores und Säuglingsseren) möglich ist. 相似文献
63.
Privatdozent Dr. Egon Ewald Pribram 《Journal of molecular medicine (Berlin, Germany)》1927,6(30):1423-1426
Ohne Zusammenfassung 相似文献
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65.
Lars Lund Malene C. Engebjerg Lars Pedersen Vera Ehrenstein Mette Nørgaard Henrik Toft Sørensen 《European urology》2009
Background
Hypospadias is a relatively common congenital malformation. Data on temporal trends in prevalence of hypospadias are conflicting. It is unclear whether changes of maternal age distribution over time are associated with changes in hypospadias prevalence.Objective
To study changes in prevalence of hypospadias in Denmark during a 29-yr period and to investigate whether maternal age was associated with the prevalence of hypospadias.Design, setting, and participants
Through Denmark's National Patient Registry, covering all Danish hospitals, we identified all boys diagnosed with hypospadias in Denmark. From the Danish Medical Birth Registry, we obtained information on maternal age and on the annual total number of live-born boys from 1977 to 2005.Measurements
Prevalence of hypospadias at birth.Results and limitations
Among 921 745 boys born alive from 1977 to 2005, we identified 3490 boys with hypospadias. The prevalence increased from 0.24% in 1977 to 0.52% in 2005, corresponding with an annual increase in prevalence of 2.40% (95% confidence interval: 1.94–2.86). The prevalence of hypospadias did not differ according to maternal age. The mean annual prevalence was 0.38% in sons of mothers aged ≤25 yr, 0.37% in sons of mothers aged 26–30 yr, 0.39% in sons of mothers aged 31–35 yr, and 0.39% in sons of mothers >35 yr.Conclusions
The hypospadias prevalence was increasing in Denmark from 1977 to 2005. Increased maternal age did not explain this trend. 相似文献66.
Dimitri Gambachidze Chloë Lefvre Emmanuel Chartier‐Kastler Marie‐Aime Perrouin Verbe Jacques Kerdraon Guy Egon Alexia Even Pierre Denys Evelyne Castel‐Lacanal Xavier Gam Alain Ruffion Juliette Hascoet Benoit Peyronnet Haude Chaussard Kvin Lo Verde Gilles Karsenty Vronique Ph 《Neurourology and urodynamics》2019,38(6):1713-1720
67.
Karin A. W. Wadt Anne-Marie Gerdes Thomas V. O. Hansen Birgitte G. Toft Lennart Friis-Hansen Mette K. Andersen 《Familial cancer》2012,11(3):535-537
Hereditary papillary renal carcinoma (HPRC) is a highly penetrant hereditary renal cancer syndrome caused by germline missense mutations in the c-MET proto-oncogene. HPRC is clinically characterized by multiple bilateral papillary renal-cell carcinomas. Here we report a family with a novel missense mutation in c-MET. The original pathology report of four primary kidney cancers (1988–1997) revealed renal-cell carcinoma. A revised report described multiple adenomas and papillary renal-cell carcinomas with focal clear cells and a mixture of type 1 and type 2 pattern, emphasizing the importance of revised pathology examinations in possible hereditary renal-cell carcinomas especially when described before 1997. 相似文献
68.
Ole H. Larsen Niels Clausen Egon Persson Mirella Ezban Jørgen Ingerslev Benny Sørensen 《British journal of haematology》2009,144(1):99-106
The present study evaluated dynamic coagulation profiles, platelet aggregation, and thrombin generation in whole blood (WB) from eight children with thrombocytopenia during chemotherapy, and the haemostatic potential of platelets (+60 × 109 /l), recombinant factor VIIa (rFVIIa – NovoSeven® ), and a potent rFVIIa analogue (NN1731) both at 1 and 4 μg/ml. Dynamic WB coagulation profiles were recorded by thrombelastometry employing activation with tissue factor (TF – Innovin® ) at low concentrations. The baseline WB coagulation patterns were characterised by a prolonged clotting time (CT) and a pronounced reduction in clot propagation (MaxVel). WB platelet aggregation signal was five times lower in the study group compared with measurements in modelled thrombocytopenic WB from healthy volunteers. In vitro addition of fresh platelets reversed the coagulopathy. Addition of rFVIIa induced no significant changes in the thrombelastographic profile, whereas spiking with NN1731 shortened the CT significantly. The changes in WB thrombin generation reflected the changes in the MaxVel. In modeled thrombocytopenic WB from healthy individuals, both rFVIIa and NN1731 exhibited a pronounced haemostatic effect with NN1731 showing greater potency than rFVIIa. Compromised platelet function in the study group was assumingly responsible for the weakened haemostatic potential of rFVIIa as well as that of NN1731. 相似文献
69.
70.
Egon Heiss Nikolay Natchev Christian Beisser Patrick Lemell Josef Weisgram 《Anatomical record (Hoboken, N.J. : 2007)》2010,293(8):1416-1424
In tetrapods, the oropharyngeal cavity and its anatomical structures are mainly, but not exclusively, responsible for the uptake and intraoral transport of food. In this study, we provide structural evidence for a second function of the oropharynx in the North American common musk turtle, Sternotherus odoratus, Kinosternidae: aquatic gas exchange. Using high‐speed video, we demonstrate that S. odoratus can grasp food on land by its jaws, but is afterward incapable of lingual based intraoral transport; food is always lost during such an attempt. Scanning electron microscopy and light microscopy reveal that the reason for this is a poorly developed tongue. Although small, the tongue bears a variety of lobe‐like papillae, which might be misinterpreted as an adaptation for terrestrial food uptake. Similar papillae also cover most of the oropharynx. They are highly vascularized as shown by light microscopy and may play an important role in aquatic gas exchange. The vascularization of the oropharyngeal papillae in S. odoratus is then compared with that in Emys orbicularis, an aquatic emydid with similar ecology but lacking the ability of underwater respiration. Oropharyngeal papillae responsible for aquatic respiration are also found in soft‐shelled turtles (Trionychidae), the putative sister group of the kinosternids. This trait could therefore represent a shared, ancestral character of both groups involving advantages in the aquatic environment they inhabit. Anat Rec 293:1416–1424, 2010. © 2010 Wiley‐Liss, Inc. 相似文献