Sexual behavior survey and screening for chlamydia and gonorrhea in university students in South Korea

BACKGROUND: The purpose of the present study was to define the prevalence of genital Chlamydia trachomatis and Neisseria gonorrhoeae infections and status of sexual risk behavior among university students (18-25 years old) in the capital region of South Korea. METHODS: Participants filled out a self-administered questionnaire related to sexuality. First-void urine was analyzed for chlamydial and gonococcal infection by strand displacement amplification (BDProbTecET, BD Diagnostic Systems, MD). RESULTS: A total of 622 students from 15 colleges in three universities took part in the study. The median age was 21 and 39.1% of them reported having sexual intercourse at least once. The prevalence of C. trachomatis among sexually active men and women was 8.4% and 10.6%, respectively. Gonococcal infection was noted in one symptomatic male. Factors significantly associated with infection were the number of sexual partners during past year and lifetime and condom use. CONCLUSIONS: This is the first sexually transmitted infection (STI) screening in university students in South Korea. Urine-based STI screening was both feasible and acceptable in university students in South Korea. It should be considered a routine part of programs to control STI nationally.     

改良无抽搐电休克合并氟西汀与单用氟西汀治疗抑郁症的对照研究

目的观察改良无抽搐电休克(MECT)合并氟西汀治疗抑郁症的疗效及副反应。方法将60例符合CCMD-3抑郁发作诊断标准的抑郁症患者随机分为MECT合并氟西汀治疗组和单用氟西汀治疗组,共观察6周。采用汉密顿抑郁量表、汉密顿焦虑量表、临床总体评定量表评定临床疗效,采用副反应量表评定副反应。结果根据HAMD评分,两组2周末显效率分别为80%、40%,两组间差异具有显著性(P<0.05);6周末显效率分别为93.3%、76.7%,差异无显著性(P>0.05)。MECT并氟西汀治疗组HAMA评分在1、2、4周末明显少于单用氟西汀组,且有显著性差异(P<0.05或P<0.01)。MECT并氟西汀治疗并未增加副反应,且失眠少于氟西汀组(P<0.05)。结论MECT并氟西汀治疗抑郁症起效快、疗效确切、安全。     

肠系膜血管病变引起的急腹症八例报告

目的：全面认识肠系膜血管病变引起的急腹症的严重性，提高疗效。方法：对8例临床特点、治疗方法和效果进行了分析比较。结果：6例经手术病理证实，初诊多表现为急腹症，症状和体征不相符，5例误诊，1例术前确诊，2例肠系膜血管供血不足经CT及腹腔动脉造影明确诊断并经药物治疗，7例治愈，1例死亡。结论：该病较少见，症状和体征无特异性，难以做出准确的诊断，B超和CT是较敏感的检查，对诊断有积极的作用。早期切除坏死肠段，包括静脉阻塞的肠系膜部分，术中和术后抗凝治疗是预防复发、降低病死率的重要措施。     

酪氨酸与依那普利、硝苯吡啶改善高原移居者脑—体功效的对比研究

目的：探讨药物改善和提高低氧条件下人脑－体工作能力的作用。方法：随机选择进入海拔3700m6个月的某部汉族男性青年30名，分别口服，甲组：自制炒面胶囊10人，乙组：酪氨酸10人，丙组：依那普利、硝苯吡啶10人，连续不间断服用15天，于服药前、服药15天后，停药10天后三个阶段应用EGM型自行车功量义进行达负荷的运动（负荷指标：W225．P175－180次／分），运动后10分钟采用DDX－200型电脑多功能心理生理测试仪进行三个阶段运动后的左右、上下肢体交叉动作频率与光信号视觉记忆测验，进行结果比较。结果：服药15天运动后服药前运动后比较，右手左脚交叉作频率测验，总次数、正确次数及错误次数量显著增多（P＜0．01或P＜0．05），左手右脚交叉动作频率测验，总次数，正砍次数显著增多（P＜0．01或P＜0．05），错误次数显著减少（P＜0．01）。服药15天运动后乙、丙组与停药10天运动后比较，左右手左右肢体交叉动作频率测验，总次数正确次数显著增多（P＜0．01或P＜0．05），停药10天运动后乙、丙组与服药前运动后比较，右手左脚交叉运动频率总次数、正确次数，错误次数均显著增多（P＜0．01或P＜0．05），左手右脚交驻动作频率乙组总次数、正确次数、丙组正确次数显著增多（P＜0．01或P＜0．05）。服药15在运动后，乙组与丙组比较，右左脚交叉动作频率正确次数显著增多（P＜0．01），在手右脚交叉动作频率正确次数显著增多，错误次数显著减少（P＜0．01或P＜0．05）。视觉记忆测验，服药15天运动后，错误次数显著小于服药前运动后（P＜0．01），停药10天运动后错误次数显著少于服药前运动后（P＜0．01），服药15天运动后错误次数显著少于停药10天运动后（P＜0．01）。结论：酪氨酸与依那普利、硝苯吡啶均能有效的提高和改善原低氧条件下的脑－体工作能力，停药10天后仍能保持一定作用，酪氨酸作用优于依那普利，硝苯吡啶。该研究对促进高原劳动能力及军事作业效率有较强的实用意义。     

Characterization of macrophage function in Mycobacterium lepraemurium-infected mice: sensitivity of mice to endotoxin and release of mediators and lysosomal enzymes after endotoxin treatment

Mycobacterium lepraemurium (MLM) infection increases the sensitivity of mice to lipopolysaccharide (LPS) as do infections with other intracellular parasites. Tumour necrosis factor (TNF), lymphocyte activating factor (LAF) and increased levels of various lysosomal and cytoplasmic enzymes were found in serum samples taken 2 h after intravenous injection of a small dose of LPS suggesting that damage to a variety of cell types, including macrophages, had occurred. Sera from moribund MLM-infected mice not injected with LPS also demonstrated significant levels of TNF compared with controls. Intravenous injections of silica into leprous mice also led to increased levels of serum lysosomal and cytoplasmic enzymes but did not give rise to a significant amount of TNF or LAF. Moreover, in contrast to LPS treatment, the injection of silica did not lead to the death of leprous mice. These findings suggest that the phagocytic cells of the infected animals did not contribute to the production of these mediators after LPS challenge. Rather, the non-phagocytic granuloma macrophages or other unidentified cell types seemed to provide the main source of the monokines TNF and LAF in vivo in the present model. These mediators may have important implications for the immunopathology of MLM infection.