道路桥梁桩基础沉降性状及计算分析

由桥梁桩基实测沉降的统计分析,揭示了桩端持力层的性质对桩基的沉降性状具有显著的影响;经5组桩基进一步的计算比较,表明桩端持力层压缩模量计算值的离散是造成桩基计算沉降偏离实际沉降的主要原因之一.提出了用静力触探Ps值修正Es值的方法,并且讨论了桩基附加应力的计算及计算沉降经验系数(ψs)的取值问题.     

我国农村地区实施大病统筹合作医疗或医疗保险方案的技术缺陷

在我国中等发达及上农村地区,大病统筹合作医疗或医疗保险以其可缓解农村居民的就医经济风险而受到欢迎,但是在方案的拟订过程中尚存在一些明显的技术缺陷,比如,“大病”的技术定义、农村居民就医经济风险分析、风险临界线界定、保险经付比测算和保险费率厘定等,这些技术的缺乏,已严重影响农村合作医疗或医疗保险的推广和实施效果。     

Aggregation inhibitory activity of minor acetophenones from Paeonia species

Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD2 from arachidonic acid.     

中药川芎中无机阴离子和有机酸成分的研究

目的：研究中药川芎中有机酸和无机阴离子的同时分析方法。方法：采用非抑制型阴离子交换色谱法,色谱柱为ＳｈｉｍｐａｃｋＩＣＡ１,流动相为０８ｍｍｏｌ·Ｌ－１邻苯二甲酸氢钾。结果：川芎提取液中３种有机酸和３种无机阴离子得到了较好的分离。结论：该方法分析速度快,准确,灵敏度高。     

口服Ⅱ号避孕药对血小板功能及血液凝固的影响

为了解口服Ⅱ号避孕药对血小板功能及血液凝固性的影响,本文对65名连续服药妇女进行了研究。她们的年龄为27～45(平均36.5)岁。服药期限1～17(平均6.7)年。测定项目有纤维蛋白原,血小板粘附率,血小板聚集率,Ⅷ因子相关抗原,抗凝血酶活力等。20例未服药妇女作对照。测定结果服药组血小板粘附率、聚集率及纤维蛋白原比对照组明显增高(P<0.001)。Ⅷ因子相关抗原略增高,但无统计学意义。抗凝血酶活力显著降低(P<0.001)。本文就急性心肌梗塞及血栓栓塞的潜在可能性等问题进行了讨论,并对预防此类并发症提出了建议。     

Syntheses and in vitro evaluation of water-soluble "cationic metalloporphyrin-ellipticine" molecules having a high affinity for DNA

The synthesis of hybrid "cationic metalloporphyrin-intercalator" molecules is reported. These molecules are based on 9-methoxyellipticine as intercalator and tris-(4-N-methylpyridiniumyl)metalloporphyrins having a 4-aminophenyl or a 4-hydroxyphenyl group for the attachment of the linker. The effect of the length of linker (7-13 bonds), the chemical nature of the linking group (with a carboxamido or an ether function), the position of amino group between the two parts of hybrid molecules, the number of intercalator moieties (ellipticinium) covalently attached to the metalloporphyrin, and the nature of the central metal atom (Mn, Fe, Zn) on the biological activity of these hybrid molecules were studied. In addition, these molecules have a high affinity for double-stranded DNA (affinity constant of hybrid molecule 9Mn,Me = 2.3 x 10(9) M-1 for poly[d(A-T)] and 2.8 x 10(8) M-1 for poly[d(G-C)] and are cytotoxic against murine leukemia cells L1210 in vitro (IC50 of 9Mn,Me = 0.8 microM). Their cytotoxicities are dependent on the nature of central atom. Iron derivatives are less active than manganese analogues and the corresponding zinc derivatives are nearly inactive despite their same affinity for nucleic acids. These highly water-soluble hybrid molecules could be considered as efficient bleomycin models based on a cationic metalloporphyrin.     

非体外循环下小儿腔肺吻合术疗效分析

为总结体外循环与非体外循环的两组病例行双向腔肺吻合(M．Glenn)术后的转归，以客观评价小儿施行非体外循环腔肺吻合术的可行性，将2000年5月--2002年11月行单纯M．Glenn术的32例患儿(年龄0．33--ll岁，体重6—32kg)分为两组，A组(n＝16)为体外循环组，B组(n＝16)为非体外循环组。所有病例监测术后1、6、12、24、48h氧合指数(OI)；测定人ICU即刻(T1)、呼吸机撤离前、后(T2和T3)3个时间点的中心静脉压(CVP)、跨肺压(TPG)、跨脑压(TCP)；记录两组病例手术时间(OT)、术后并发症、术后12h用血球量、呼吸机使用时间(VT)、ICU滞留时间(IT)以及住院费用。结果显示，B组术后OI均高于A组，尤其在术后lh和6h，OI分别为A组的1．4倍和1．3倍，差异有非常显著性(P＜0．01)。尽管撤机前B组CVP为A组的1．3倍(P＜0．05)，TCP明显低于A组，但撤机后两组差异无显著性。两组VT、IT差异虽无显著性(P＞0．05)，但B组术后12h用血球量、并发症明显降低，住院开支亦较A组节省了约30％(P＜0．05)。提示非体外循环技术应用于小儿双向腔肺吻合术是可行且有利的。     

Dr. DING Hong-shan＇s Experience of Tuina in Treating Childhood Cerebral Palsy

My late father Dr. DING Hong-shan was a senior Chinese medical doctor and learnt thumb-massage therapy from his forefathers. In his decades of years of clinical practice, upon the physiological nature of the children‘s tender constitution, he created a “one-hand and three-acupoint Tuina” (the thumb, forefinger and middle finger of one hand simultaneously massaging three acupoints or three meridians) in combination with thumb-massage therapy. It is suitable for childhood limb diseases, especially for infantile cerebral palsy. It is now introduced as follows.     

儿童期单纯肥胖症的行为治疗

为研究适合中国肥胖儿童的行为治疗方案及效果，对２４例（男女各１２例）１３岁单纯肥胖儿童进行３年行为治疗纵向研究。２４名同年龄、性别、年级非肥胖儿童为正常对照组。观测参数有身高、体重、四处皮脂、腰、臀围及其比例、有氧运动能力（最大耐受时间和运动距离）。体育测试成绩包括引体向上、跳远、８００米跑、仰卧起坐，满分为３０分。按运动处方每天运动２小时，每周５天。在医生指导下肥胖儿童写行为分析和行为矫正方案。有关肥胖指标年减少率（男／女）体脂含量为２３％～４２％，肥胖度２．８％～２．１％，腰／臀比２．５％～２．６％，四处皮脂和５．７％女０．８％～１．０％），有氧能力明显进步。体育成绩肥胖干预组３０％达满分，７０％为２７～２９分。肥胖对照组６０％为２０分，３０％为１５～１９分。提示儿童期单纯肥胖症的干预方案应以健康教育和运动处方为基础，行为治疗为核心技术；在家庭日常生活中持续进行，家长、教师、医务人员应共同参与。