Experimental Study on Self-Centering Performance of the SMA Fiber Reinforced ECC Composite Beam

The combination of superelastic shape memory alloy fibers and ECC materials can form a new SMA fiber reinforced ECC composite material (SMAF-ECC) with good self-centering performance. In order to study the self-centering performance of the new composite material, 6 groups of pre-notch beam specimens were made for three-point bending cyclic loading tests, and the failure phenomenon, hysteresis curve, self-centering effect and influencing factors of the specimens were analyzed. The research results show that when the SMA fibers are effectively anchored in the ECC matrix, the SMA fibers can exert the superelastic properties to provide the ECC beams with recoverying force, and realize the crack self-closure and deflection self-recovery function for the beams, with the minimum residual crack width and deflection is only 0.9 mm and 1.3 mm respectively. Increasing fiber content can cause a small increase in the self-centering ability of the beams. However, only when the fiber diameter is appropriate, better self-centering effect can be achieved, but the difference caused by fiber diameter in the test was only 5%. SMA Fiber end forms have significant influence on self-centering performance. The knotted end beam can get a more than 70% self-centering ratio, while the straight end beams and bended end beams have no self-centering ability. The research results provide important reference for the research and application of this new self-centering materials and their structures.     

复方调脂胶囊辅助治疗肾病综合征40例疗效观察

目的:观察复方调脂胶囊辅助治疗肾病综合征的临床疗效。方法:79例病例随机分为两组,其中对照组39例,治疗组40例。所有病例均按原发性肾病综合征的措施治疗,治疗组在此基础上加用复方调脂胶囊口服,观察两组病例治疗后的疗效。结果:两组病例治疗后总有效率比较差异有统计学意义(P0.05);治疗组血脂水平与治疗前比较,差异有统计学意义(P0.05,P0.01)。结论:复方调脂胶囊能有效降低血脂,对提高肾病综合征的治疗有积极意义。     

Intraoperative microwave inactivation in‐situ of malignant tumors in the scapula

Objective: To explore the feasibility and effect of microwave in situ inactivation of malignant primary or metastatic tumors in the scapula. Methods: Seventeen patients (12 men, 5 women, mean age 48 years [range, 13–59 years]) with malignant primary or metastatic tumors involving the scapula were treated by microwave inactivation between June 1998 and February 2008. There were12 malignant primary bone and 5 metastatic tumors. In 14 cases Area Sl was involved and in 3 cases both Areas S1 and S2. All 17 cases were by making a dorsal arc‐ or “∩‐” shaped incision to expose the tumor, protecting the surrounding soft tissues with a copper grid, and then heated the tumors locally with 2450 MHz microwave to 50°C for 20 min, after which all or some of the necrotic tumor tissue was removed, preserving the support role of the scapula. Results: The operation time was 60–180 min (mean 120 min) and blood loss was 300–1000 mL (mean 460 mL). No serious intraoperative or postoperative complications occurred in any patient. The patients were followed up for 3 months to 10 years (mean 4.2 years). Three patients with Ewing's sarcoma in the scapula had pulmonary, cerebral and systemic multiple metastases and died 8～24 months after surgery. Three patients with malignant fibrous histiocytoma died of pulmonary and systemic multiple metastases 10～22 months after surgery; one patient had recurrence 6 months after surgery and survived with tumor. Five patients with metastatic tumor in the scapula died of non‐scapular metastatic tumor 6～14 months after surgery. The other five patients with primary malignant bone tumors had no recurrence or metastasis during follow‐up. Three cases had restricted extension of the shoulder joint with unrestricted protraction and retroflexion after surgery. Conclusion: In situ microwave inactivation features simple surgery, reliable effects and patient acceptability, making it an ideal surgical method for malignant tumors in the scapula.     

Prognostic value of thoracic tumor staging and volume parameters in non-small cell lung cancer patients with synchronous solitary bone metastasis

BackgroundNon-small cell lung cancer (NSCLC) patients with synchronous solitary metastasis are a heterogeneous population. The analysis and evaluation of NSCLC patients with synchronous solitary bone metastases by cTN stage (thoracic tumor staging) and volume parameters have not yet been studied. The purpose of this study is to estimate the prognostic value of cTN stage and volume parameters obtained by fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in NSCLC patients with synchronous solitary bone metastasis.MethodsA total of 157 NSCLC patients with synchronous solitary bone metastasis were retrospectively analyzed. Patients’ cTN stage, metabolic tumor volume (MTV) parameters, and clinical data were collected. Kaplan-Meier survival analysis and a Cox regression model were performed to determine the association between each factor and overall survival (OS). Finally, time-dependent receiver operating characteristic (TDROC) curve analysis was used to assess the predictive capacity of the independent prognostic factors.ResultsKaplan-Meier survival analysis showed significant differences between subgroups in terms of cTN stage. The median OS of group I was 44 months, and the 5-year survival rate was 39.6%. In the multivariate Cox regression analysis, cTN stage, MTV of the whole body (MTVwb), and MTV of thorax (MTVtho) were significantly associated with patient OS, even after adjusting for other clinical factors. However, MTV of bone (MTVbon) was not found to be an independent prognostic factor. TDROC curve analysis showed that cTN stage, MTVwb, and MTVtho had good predictive capacity for NSCLC patients with synchronous solitary bone metastasis. Compared with cTN stage and MTVtho, MTVwb had obviously better predictive specificity and sensitivity for the 5-year survival rate [5-year area under the curve (AUC) of MTVwb =0.844 vs. cTN stage (P=0.035) vs. MTVtho (P=0.052)]. The best cutoff value of MTVwb was 33.05.ConclusionsThe results of this study confirmed that cTN stage, MTVwb, and MTVtho were independent prognostic factors of NSCLC patients with synchronous solitary bone metastases. These factors can be used for risk stratification of these patients. TDROC curve analysis indicated that cTN stage, MTVtho, and MTVwb had good performance for survival prediction.     

南宁年青人主动脉及冠状动脉的平滑肌细胞骨架系统免疫组化研究

用免疫组化技术染动脉壁的平滑肌细胞骨架系统,发现南宁年青人主动脉和冠脉内膜平滑肌细胞有较多结蛋白(Oesmin),然而来自动脉粥样硬化高发地区的欧美人的资料说弹力型及肌肉型动脉内膜都缺乏这种蛋白。一般认为平滑肌细胞(SMC)有结蛋白反映其分化成熟。成熟的SMC增生程度轻和分泌较多的硫酸乙酰肝素蛋白聚糖,可能与南宁动脉粥样硬化发病率低有关,值得注意。     

HLA-肽四聚体和过继性免疫疗法在防止巨细胞病毒疾病中的应用

背景：抗病毒药物能减少早期的巨细胞病毒疾病,但有较强的毒性和引起晚期巨细胞病毒疾病发生的可能。为了更好地防治巨细胞病毒疾病,研究细胞毒性T淋巴细胞控制巨细胞病毒再活化的作用是很关键的,荧光HLA-肽四聚体是一个很好的工具,被用来监测移植受者的巨细胞病毒特异细胞毒性T淋巴细胞的恢复。 目的：探讨HLA-肽四聚体和过继性免疫疗法在治疗巨细胞病毒疾病中的作用。 方法：由第一、二作者检索2003/2009 PubMed数据库及万方数据库有关移植后巨细胞病毒特异细胞毒性T淋巴细胞检测、抗病毒药物应用、HLA肽四聚体应用、过继性免疫治疗作用的文献,英文检索词为“HLA-peptide tetramers, cytomegalovirus, specific CTL, adoptive immunotherapy”,中文检索词为“HLA-肽四聚体,巨细胞病毒,特异细胞毒性T淋巴细胞,过继性免疫治疗”。排除重复性研究,纳入29篇归纳总结。 结果与结论：用巨细胞病毒特异细胞毒性T淋巴细胞进行的过继性免疫治疗是非常完美的策略,然而,产生这些细胞是昂贵和耗时的,因此治疗不是在每个移植中心都能进行。用HLA-肽四聚体从巨细胞病毒血清阳性供者外周血中选择巨细胞病毒特异细胞毒性T淋巴细胞是非常有希望的策略,使过继性免疫疗法更容易进行。 关键词：HLA-肽四聚体;过继性免疫治疗;巨细胞病毒疾病;特异T细胞;细胞毒性T淋巴细胞     

Is automatic CPAP titration as effective as manual CPAP titration in OSAHS patients? A meta-analysis

Purpose  

It is costly and time-consuming to conduct the standard manual titration to identify an effective pressure before continuous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA) patients. Automatic titration is cheaper and more easily available than manual titration. The purpose of this systematic review was to evaluate the effect of automatic titration in identifying a pressure and on the improvement of apnea/hyponea index (AHI) and somnolence, the change of sleep quality, and the acceptance and compliance of CPAP treatment, compared with the manual titration.