Clinical observation on effect of shuanghuang shengbai granule on chemotherapy induced myelpsuppression in tumor patients and on ultrastructure of bone marrow in mice

To observe the leucocyte increasing effect of Shuanghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy and the bone marrow microenvironment protecting effect in mice.

Methods  

Patients of non-small-cell pulmonary, mammary, gastric or intestinal cancer, who were ready for receiving re-treatment of chemotherapy, were enrolled and divided into 4 groups randomly. The 28 cases in SHSBG group A received chemotherapy combined with SHSBG; the 27 in the SHSBG group B received chemotherapy alone at first, and SHSBG was added when their peripheral white blood cell (WBC) count lowered to <4×10⁹/L; the 33 in control group A and 24 in control group B were treated by the method similar to that applied to SHSBG group A and B respectively but with Rubidate instead of SHSBG. Experimental study of electron microscopic observation on bone marrow ultrastructure in mice was also conducted.     

用SF—36量表评价慢性病患者的生命质量

目的 用SF－36量表分析慢性疾病对生命质量的影响。方法 在四川省某城乡用SP－36量表对438名慢性疾病患者进行调查,并按照ICD－8进行疾病分类,对不同系统疾病患者的生命质量进行分析。结果 不同系统疾病患者的生命质量在SF－36量表所测的不同领域均低于一般人群（≥40岁）,不同系统疾病患者在躯体活动性能、社会功能、活力和心理功能四个领域均有差别。影响生命质量的主要疾病有精神疾患、血液及造血器官疾病,传染病和寄生虫病。结论 慢性病降低了患者的生命质量。不同系统疾病对生命质量的影响程度不同,SF－36量表适用于评价慢性病患者的生命质量。在慢性疾病的预防控制中,生命质量应作为健康评价指标。     

病案首页的准确填写与统计报表的关系

病案首页是医院医疗统计最基本的数据,《中华人民共和国统计法》第二条规定:“统计的基本任务是对国民经济和社会发展情况进行统计调查、统计分析,提供统计资料和统计咨询意见,实行统计监督。”数据不准确为上级卫生行政部门了解和掌握居民的医疗需求,医疗服务情况,编制区域医疗规划与卫生事业发展计划,评价医疗服务的社会效益和经济效益,对领导部门决策、与世界各国的资料交流等都会产生不良影响。所以病案首页的准确填写很重要,要认真、如实、规范才能真正反映实际情况。现就常见不规范或填写不准确的主要情况列出如下:     

急性冠状动脉综合征血沉和C-反应蛋白检测及临床意义

目的　观察急性冠状动脉综合征患者血沉 (ESR)和C -反应蛋白 (CRP)阳性率 ,推断炎症反应在急性冠脉事件中的作用 ,及抗炎治疗对其影响。方法　测定 5 8例急性冠脉综合征患者的ESR和CRP阳性率 ,并与对照组进行比较。再分为抗炎组 ,非抗炎组 ,于治疗 1周后复查ESR和CRP ,进行治疗前后比较。结果　急性冠脉综合征患者ESR和CRP阳性率明显增高 ,抗炎后下降较明显。结论　作为炎症标记物 ,ESR值、CRP阳性率可作为预测因子 ,抗炎治疗在急性冠脉事件中可能是有益的     

Effect of l-carnitine supplementation on renal anemia in patients on hemodialysis: a meta-analysis

International Urology and Nephrology - l-carnitine is an amino acid derivative that is thought to be helpful for treating renal anemia in hemodialysis patients. However, the mechanism remains to be...     

Efficacy of non-ablative fractional 1440-nm laser therapy for treatment of facial acne scars in patients with rosacea: a prospective,interventional study

Lasers in Medical Science - Acne scarring is one of the most common facial skin disorders. The appropriate treatments for acne scars in patients with rosacea have not been studied. This study was...     

Comparative study of different transplantation methods of adipose tissue-derived stem cells in the treatment of erectile dysfunction caused by cavernous nerve injury

We aimed to compare intracavernosal injection (ICI), tail vein injection (IV), and periprostatic injection (PPI) of adipose-derived stem cells (ADSCs) for their ability to improve erectile function in cavernous nerve injury-induced erectile dysfunction (CNIED) rats and to explore the possible mechanism. Eighty-four male SD rats were divided into the sham group (n = 6), BCNI group (bilateral CN crush injury, n = 6), PBS-ICI group (n = 6), PBS-IV group (n = 6), PBS-PPI group (n = 6), ADSC-ICI group (n = 18), ADSC-IV group (n = 18) and ADSC-PPI group (n = 18). ADSCs were labelled with 5-ethynyl-2′-deoxyuridine (EdU), and six rats each in the ADSC-ICI group, ADSC-IV group, and ADSC-PPI group were sacrificed 2, 7, and 28 days after injection. EdU-labelled ADSCs were tracked by immunofluorescence staining. The intracavernosal pressure (ICP)/mean arterial pressure (MAP) ratio, neuronal nitric oxide synthase (nNOS)-positive nerve fibres in the dorsal penile nerve and the smooth muscle/collagen ratio in the cavernosum between groups were also evaluated. ADSCs can significantly improve erectile function through ICI or IV. The two are similar in efficacy and superior to PPI. The mechanism may be that after CN injury, ADSCs are recruited to around the MPG and secrete a variety of neurotrophic factors that promote the repair of the CN, thereby improving erectile function.     

Does the false-negative rate for 1 or 2 negative sentinel nodes after neo-adjuvant chemotherapy translate into a high local recurrence rate?

Prospective trials demonstrate that sentinel node (SN) biopsy after neo-adjuvant chemotherapy (NACT) has a significant false-negative rate (FNR) when only 1 or 2 SNs are removed. It is unknown whether this increased FNR correlates with an elevated risk of recurrence. Tumor Registry data at an NCI-Designated Comprehensive Cancer Center were reviewed from 2004 to 2018 for patients having a negative SN biopsy after NACT. Among 190 patients with histologically negative nodes after NACT having 1 (n = 42), 2 (n = 46), and ≥3 (n = 102) SNs, axillary recurrences occurred in 7.14%, 0%, and 1.96% (p = 0.09), breast recurrences occurred in 2.38%, 6.52%, and 0.98% (p = 0.12), and distance recurrences occurred in 16.67%, 8.70%, and 7.84% (p = 0.27), respectively. Time to first recurrence did not differ by SN count (p = 0.41). After adjustment for age, race, clinical stage, and receptor status, there were no differences in the rates of axillary (p = 0.26), breast (p = 0.44), or distance recurrence (p = 0.24) by numbers of SNs harvested. Median follow-up was 46.8 months. Despite higher post-NACT FNRs reported in randomized trials for patients having <3 sentinel nodes, recurrence rates were not significantly different for 1 versus 2 versus ≥3 SNs. This suggests that patients having 1 or 2 post-NACT SNs identified may not necessitate axillary dissection.