全文获取类型
收费全文 | 457篇 |
免费 | 23篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 4篇 |
妇产科学 | 8篇 |
基础医学 | 70篇 |
口腔科学 | 63篇 |
临床医学 | 33篇 |
内科学 | 119篇 |
皮肤病学 | 1篇 |
神经病学 | 11篇 |
特种医学 | 3篇 |
外科学 | 46篇 |
综合类 | 4篇 |
预防医学 | 41篇 |
眼科学 | 2篇 |
药学 | 56篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 7篇 |
2022年 | 3篇 |
2021年 | 12篇 |
2020年 | 11篇 |
2019年 | 17篇 |
2018年 | 16篇 |
2017年 | 11篇 |
2016年 | 19篇 |
2015年 | 18篇 |
2014年 | 25篇 |
2013年 | 23篇 |
2012年 | 48篇 |
2011年 | 37篇 |
2010年 | 20篇 |
2009年 | 20篇 |
2008年 | 28篇 |
2007年 | 30篇 |
2006年 | 24篇 |
2005年 | 21篇 |
2004年 | 13篇 |
2003年 | 17篇 |
2002年 | 26篇 |
2001年 | 4篇 |
2000年 | 8篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1992年 | 6篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1984年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有483条查询结果,搜索用时 171 毫秒
41.
Unsuccessful Pulsed Radiofrequency of the Sphenopalatine Ganglion in Patients with Chronic Cluster Headache and Subsequent Successful Thermocoagulation
下载免费PDF全文
![点击此处可从《Pain practice》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Damián Claudio Bendersky MD Santiago Matias Hem MD Claudio Gustavo Yampolsky MD 《Pain practice》2015,15(5):E40-E45
We present the results of pulsed and continuous radiofrequency (CRF) of the sphenopalatine ganglion in a case series of 3 patients with chronic cluster headache (CCH). Three patients were referred to our neurosurgical department because of CCH, which was refractory to pharmacological treatment. They underwent pulsed radiofrequency of the sphenopalatine ganglion (PRF‐SPG), and the procedure was performed through an infrazygomatic approach. In the PRF procedures, we applied 2 cycles of PRF at 42°C and 45 V for 120 seconds, with a pulse frequency of 2 Hz and a pulse width of 20 ms. In those procedures where thermocoagulation was carried out, 2 CRF lesions at 80°C for 90 seconds each were performed. Following corticosteroid and local anesthetic (40 mg of methylprednisolone and 1 mL of 1% lidocaine) injection, 2 patients had no pain relief at all, whereas the third one experienced a partial response, which lasted only 1 month and his pain then returned to its baseline level. Thus, this outcome was assessed as a nonsustained partial response. Therefore, all of them underwent a CRF lesioning of the SPG, and after this procedure, they achieved complete pain relief until the end of the follow‐up period. Furthermore, the associated autonomic manifestations disappeared. The 3 patients presented in this case series failed to achieve adequate pain relief after PRF‐SPG. However, these same patients subsequently underwent a successful CRF of the SPG. 相似文献
42.
Damián J 《American journal of epidemiology》2012,175(8):857; author reply 857-857; author reply 858
43.
Cruz-Bustillo D Villasana L Llorente F Casadesús D García E Syrris P Carter N Guerra R Llanio R 《International journal of colorectal disease》2002,17(5):344-347
BACKGROUND AND AIMS: Familial adenomatous polyposis (FAP) is an autosomal dominant condition characterized by multiple adenomatous polyps in the colon and rectum that inevitably develop into adenocarcinomas if the patient's colon is not removed in time. To date more than 500 mutations related to the disease have been identified in the APC (adenomatous polyposis coli) gene. The molecular study of FAP families was initially introduced in Cuba with the aim of identifying the asymptomatic carriers of APC gene mutations in each family. PATIENTS AND METHODS: We studied 23 individuals from 17 Cuban families who had been diagnosed clinically with FAP. Peripheral DNA was extracted from the index case of each family. Exon 15 of the APC gene was screened for germinal mutations using PCR and DNA heteroduplex. RESULTS: Three different germinal mutations were identified in the mutational clustering region of APC gene by sequencing analysis in five FAP unrelated families. Three families carry the most frequent mutation in APC in codon 1309, while the other two families carry mutations in codons 1061 and 1192, respectively. Two asymptomatic carriers of one family were detected, and later the disease was confirmed by colonoscopy in a very early stage while six members at risk were found to be negative. CONCLUSION: For the first time in Cuba molecular diagnosis of FAP was performed and the development of colorectal cancer prevented in asymptomatic carriers. 相似文献
44.
45.
46.
Paolo Stefani Casare Selli M.D. Giulio Nicita Alberto Lapini Andrea Dami 《Cardiovascular and interventional radiology》1989,12(1):18-21
Two patients presenting with urinary fistulas following partial resection of hydronephrotic kidneys were successfully treated
with selective arterial embolization causing functional ablation of the remaining renal parenchyma. This technique is simpler
than surgical reexploration. 相似文献
47.
Xanthogranulomatous pyelonephritis occurred in a pelvic ectopic kidney in a 70-year-old man. Pre-operative diagnosis was possible due to the typical appearance at CT scan of central lithiasis and multiple rounded areas of low density with enhancing rims (bear paw sign). 相似文献
48.
49.
50.
Alfredo De Diego Damiá Julio Cortijo Gimeno M. José Selma Ferrer Montserral León Fabregas Patricia Almudever Folch Javier Milara Paya 《Archivos de bronconeumologia》2011,47(9):447-453
IntroductionCigarette smoke is the main cause of inflammation in COPD. The mechanisms that differentiate smokers who develop COPD are diverse. In this study, we analyzed the presence of cytokines in the respiratory secretions of smokers with or without COPD and the secretory properties of the differentiated bronchial epithelium obtained from the individuals themselves after exposure to tobacco smoke.Material and methodsTwenty-seven smokers were studied, 12 of whom had COPD that had not been previously treated with steroids. In 11, samples were obtained by means of induced sputum, and the remaining samples were collected from bronchial aspiration after bronchoscopy. Concentrations of IL8, IL13, and TNFα in the supernatant were determined. The results obtained were compared between individuals with and without COPD, and we studied their relationship with the severity of COPD as expressed by the degree of obstruction, dyspnea, presence of hypersecretion and intensity of smoking. Bronchial epithelial cell cultures were obtained by air–liquid interface in 4 smokers. The samples were exposed to increasing concentrations of cigarette smoke (5%–20%) and the epithelial mRNA expressions of Muc5AC, IL8, and TNFα were determined.ResultsCOPD patients had significantly higher values of IL8 than healthy smokers (41 [22] pM vs 21 [12] pM). The values of IL8 correlated significantly with the severity of the obstruction (r=0.6; P<.05), dyspnea (r=0.45; P<.05) and the presence of hypersecretion. There was no relationship between cytokines and the intensity or duration of the tobacco habit. Cigarette smoke produced a dose-dependent increase in the expression of RNAm for Muc5AC, IL8, and TNFα.ConclusionsThere are differences in cytokine production (fundamentally IL8) between smokers and smokers with COPD which could be explained by the direct action of cigarette smoke on epithelial cells. 相似文献