梅毒治疗后血清学转归及其影响因素

梅毒治疗后血清学转归包括血清学治愈、血清固定以及血清学失败.血清学治愈是指梅毒患者经推荐方案治疗后,其血清快速血浆反应素环状卡片试验定性转为阴性或定量滴度下降至少4倍或以上.血清固定是指治疗后,患者血清快速血浆反应素环状卡片试验滴度下降到一定水平后,早期梅毒随访6～12个月、晚期梅毒随访12～24个月不再变化或上下波动＜1个滴度的现象.血清学失败是指治疗后梅毒患者血清快速血浆反应素环状卡片试验不降低,出现4倍及以上的上升现象.血清学转归与梅毒临床类型、治疗方案、起始快速血浆反应素环状卡片试验滴度、隐匿性苍白螺旋体感染、是否有人免疫缺陷病毒感染等因素有关.梅毒血清固定患者需要进行非特异性抗体定期检测,必要时给予治疗.血清学失败者,可能是病原体对治疗药物不敏感,应重新治疗.     

输卵管复通术早期通液辅以中药离子导入方法的疗效观察

目的：观察输卵管复通术早期通液辅以中药离子导入方法的疗效。方法：选择2006～2009年要求行输卵管复通术的患者100例,随机分为两组,A组以硬膜外导管做临时支架,术毕取出,术后48h在彩超监视下行输卵管通液,并辅以中药离子导入治疗;B组,硬膜外导管做支架并留置7～10d,术后第1次月经干净后3～7h进行第1次通液。观察两组术后复通率及复孕率。结果：A组和B组复通率及复孕率分别为100％和90％、80％和60％。两组比较,差异具有统计学意义（P〈0．05）。结论：输卵管复通术早期通液辅以中药离子导入的方法,复通率及复孕率均明显提高．值得临床推广使用。     

Influenza vaccine with Surfacten, a modified pulmonary surfactant, induces systemic and mucosal immune responses without side effects in minipigs

Immune responses and side effects of intranasally administered flu vaccine with the commercial product Surfacten, a modified bovine pulmonary surfactant, were investigated in minipigs. The use of minipigs was based on the anatomical resemblance of nasal lymph nodes, the principal antigen uptake site of respiratory mucosal immunity, between pig and human. Intranasal instillation of HA vaccine adjuvanted with Surfacten elicited significantly higher serum hemagglutination inhibition titers than the antigen alone, with wide cross-neutralizing activities of secretory IgA in nasal washes. No significant induction of inflammatory cytokines or migration of inflammatory cells was observed at the site of immunization or serum after the first immunization. These data suggest the potential usefulness of Surfacten for mucosal vaccination.     

栀子双仁散涌泉穴外敷治疗高血压病32例

目的:观察栀子双仁散涌泉穴外敷对高血压的效果的影响。方法:将符合标准的62例患者分为治疗组和对照组,均予西医降压治疗,治疗组加用栀子双仁散(栀子、桃仁、杏仁)涌泉穴外敷治疗。结果:治疗组与对照组相比较,治疗组可以显著地降低血压。结论:栀子双仁散涌泉穴外敷对控制高血压患者血压水平有一定效果。     

沙苑子黄酮诱导白血病细胞凋亡及对Fas、FasL表达的影响

目的 探讨沙苑子黄酮(FAC)诱导白血病细胞凋亡及其机制.方法 采用图像分析术、流式细胞术、形态学观察与免疫细胞化学等方法,研究FAC诱导K562细胞凋亡.结果 FAC对K562细胞有增殖明显抑制作用,最高抑制率达96.17%;并可诱导K562细胞凋亡,最大凋亡率达64.24%.同时,FAC可使K562细胞Fas阳性表达升高,阳性率为12.53%.结论 FAC抑制K562的增殖可能与FAC诱导细胞凋亡有关;细胞调亡可能与Fas表达升高有关.     

Study on facial motoneuronal death after proximal or distal facial nerve transection

BACKGROUND: Among the cranial nerves, the facial nerve is most liable to be damaged. Pathologic changes in the facial motor nucleus (FMN) after nerve injury are not well recognized, and the optimal time for facial nerve reconstruction after axotomy is controversial. In this study, to clarify the pathologic change in the FMN after axotomy and to determine the best time for surgery, facial motoneuronal death was investigated after facial nerve injury. METHODS: Sixty Wistar rats were divided into proximal and distal groups. In the proximal group, the right facial nerve was transected at the porus of internal acoustic meatus. In the distal group, the nerve was cut at the stylomastoid foramen. The animals were sacrificed from day 3 to day 60 after surgery, and the brainstem was fixed with 4% paraformaldehyde. The FMN were then examined in serial sections stained with Cresyl Violet, and facial motoneurons were counted under a light microscope. RESULTS: The death rate of facial motoneurons in the animals that underwent proximal axotomy was found to be higher and cell death occurred earlier than in the distal axotomy animals at every time point. Moreover, neuron death increased with time and peaked at 15 days after surgery. CONCLUSIONS: The results indicate that the injury site was correlated with facial motoneuronal death, and suggest that reconstructive surgery should be performed as early as possible.