Fulminant hepatic failure and acute intravascular haemolysis as presenting manifestations of Wilson''s disease in young children

The cases of three young children (mean age 5.8 years) in whom fulminant hepatic failure and acute intravascular haemolysis were the presenting manifestations of Wilson's disease are reported. Although diagnosis was made ante-mortem and chelation therapy instituted, the course was relentlessly fatal in all three cases. This presentation of Wilson's disease at such a young age is noteworthy.     

ADULT-ONSET STILL'S DISEASE IN INDIA

Adult onset Still's disease was provisionally diagnosed in 31patients from northern India over a period of five years, in27 of whom the diagnosis was subsequently felt to have beenconfirmed. This report describes the clinical characteristicsof these patients along with the different therapeutic measuresused and their response. Adult onset Still's disease shouldbe considered in the differential diagnosis of ‘pyrexiaof unknown origin’. KEY WORDS: Still's disease, Pyrexia of unknown origin