全文获取类型
收费全文 | 2884篇 |
免费 | 198篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 106篇 |
妇产科学 | 41篇 |
基础医学 | 469篇 |
口腔科学 | 96篇 |
临床医学 | 350篇 |
内科学 | 626篇 |
皮肤病学 | 120篇 |
神经病学 | 97篇 |
特种医学 | 309篇 |
外科学 | 344篇 |
综合类 | 96篇 |
一般理论 | 1篇 |
预防医学 | 137篇 |
眼科学 | 78篇 |
药学 | 167篇 |
中国医学 | 1篇 |
肿瘤学 | 63篇 |
出版年
2015年 | 38篇 |
2014年 | 28篇 |
2013年 | 87篇 |
2012年 | 48篇 |
2011年 | 41篇 |
2010年 | 57篇 |
2009年 | 42篇 |
2008年 | 42篇 |
2007年 | 71篇 |
2006年 | 75篇 |
2005年 | 47篇 |
2004年 | 36篇 |
2003年 | 52篇 |
2002年 | 37篇 |
2001年 | 44篇 |
2000年 | 45篇 |
1999年 | 52篇 |
1998年 | 90篇 |
1997年 | 104篇 |
1996年 | 117篇 |
1995年 | 75篇 |
1994年 | 79篇 |
1993年 | 81篇 |
1992年 | 65篇 |
1991年 | 48篇 |
1990年 | 49篇 |
1989年 | 85篇 |
1988年 | 89篇 |
1987年 | 72篇 |
1986年 | 84篇 |
1985年 | 52篇 |
1984年 | 74篇 |
1983年 | 47篇 |
1982年 | 39篇 |
1981年 | 44篇 |
1980年 | 57篇 |
1979年 | 41篇 |
1978年 | 45篇 |
1977年 | 43篇 |
1976年 | 53篇 |
1975年 | 46篇 |
1972年 | 38篇 |
1971年 | 40篇 |
1970年 | 30篇 |
1965年 | 51篇 |
1964年 | 51篇 |
1963年 | 48篇 |
1962年 | 42篇 |
1961年 | 40篇 |
1960年 | 65篇 |
排序方式: 共有3112条查询结果,搜索用时 187 毫秒
91.
E García‐Molina J Lacunza F Ruiz‐Espejo M Sabater A García‐Alberola JR Gimeno F Caizares A García P Martínez M Valds I Tovar 《Clinical genetics》2013,83(6):530-538
We aim to study the SCN5A gene in a cohort of Brugada syndrome (BS) patients and evaluate the genotype–phenotype correlation. BS is caused by mutations in up to 10 different genes, SCN5A being the most frequently involved. Large genomic rearrangements in SCN5A have been associated with conduction disease, but its prevalence in BS is unknown. Seventy‐six non‐related patients with BS were studied. Clinical characteristics and family risk profile were recorded. Direct sequencing and multiplex ligation‐dependent probe amplification (MLPA) of the SCN5A gene for identification of mutations and larger rearrangements were performed, respectively. Eight patients (10.5%) had point mutations (R27H, E901K, G1743R (detected in three families), V728I, N1443S and E1152X). Patients with mutations had a trend toward a higher proportion of spontaneous type I Brugada electrocardiogram (ECG) (87.5% vs 52.9%, p = 0.06) and had evidence of familial disease (62.5%, vs 23.5%, p = 0.03). The symptoms and risk profile of the carriers were not different from wild‐type probands. There were non‐significant differences in the prevalence of type I ECG, syncope and history of arrhythmia in carriers of selected polymorphisms. None of the patients had any deletion/duplication in the SCN5A gene. In conclusion, 10.5% of our patients had mutations in the SCN5A gene. Patients with mutations seemed to have more spontaneous type I ECG, but no differences in syncope or arrhythmic events compared with patients without mutations. Larger studies are needed to evaluate the role of polymorphisms in the SCN5A in the expression of the phenotype and prognosis. Large rearrangements were not identified in the SCN5A gene using the MLPA technique. 相似文献
92.
93.
94.
95.
A diaper bank and home visiting partnership: Initial exploration of research and policy questions 下载免费PDF全文
96.
97.
98.
99.
1. Three cases of hereditary hemolytic disease secondary to G-6-PD deficiency are described. Two of the cases were first cousins of Scotch-Irish-English descent and the mode of inheritance was believed to be sex-linked.The third case was of Turkish origin; no family studies were availale.2. The mothers, who were heterozygous for G-6-PD deficiency, showed onlyminimal expression of the defect, which was manifested by a slightly decreasedred cell survival in both mothers and an abnormal methemoglobin reductiontest in one of them.3. All three cases showed a more pronounced fall in erythrocyte ATP afterincubation with phenylhydrazine than that observed in primaquine-sensitiveNegroes whose red cells were less deficient in G-6-PD.4. It is suggested that the inability of the G-6-PD-deficient erythrocyte tomaintain adequate levels of ATP may be an important factor in the pathogenesis of the hemolytic process. Submitted on August 26, 1963 Accepted on October 24, 1963 相似文献
100.
Interventions in saphenous vein grafts present some of the most challenging problems in preventing acute complications and limiting restenosis. Available options include repeat bypass surgery, balloon angioplasty, directional atherectomy, transluminal extraction atherectomy, rotational atherectomy, laser angioplasty, and stenting. Stenting appears to provide the best acute and long-term results. Debulking with directional atherectomy prior to stenting may be helpful but its role is unproven. With any device, it is essential to attain the lowest possible residual stenosis with the least amount of manipulation. Complications with vein graft interventions are most commonly related to distal embolization, which occurs most frequently in older vein grafts with diffuse disease, large plaque volume or thrombus, or those with total occlusion. Use of thrombolytics, glycoprotein Ilb/IIIa receptor inhibitors, and thrombectomy devices may be helpful when thrombus is present. Calcium channel blockers may be beneficial when embolization of plaque debris results in slow flow or no-flow during interventions. 相似文献