关于针灸学及其研究思路和方法的若干认识

从针灸学的内涵及其与生命科学的关系出发,联系国内外针灸学术界现状,就21世纪针灸学的研究思路和方法发表见解。认为针灸学是基础与临床相结合的学科,针灸学和针灸（疗法）是既密切相关又明显有别的研究领域;没有创造就没有针灸学的传统,要正确认识针灸现代化涵义和理论－技术－产品的关系以发展“针灸产品”;要从生命科学高度思考针灸学研究,贯彻《针灸临床研究指南》以提高临床研究水平。提出借助BIO－X模式开展针灸学多学科协作研究,推进针灸学术发展。     

Phase I and pharmacological study of the oral farnesyltransferase inhibitor SCH 66336 given once daily to patients with advanced solid tumours

A single-agent dose-escalating phase I study on the farnesyl transferase inhibitor SCH 66336 was performed to determine the safety profile and recommended dose for phase II studies. Plasma pharmacokinetics were determined as well as the SCH 66336-induced inhibition of farnesyl protein transferase in vivo. SCH 66336 was given orally once daily (OD) without interruption to patients with histologically-confirmed solid tumours. Routine antiemetics were not prescribed. 12 patients were enrolled into the study. Dose levels studied were 300 mg (6 patients) and 400 mg (6 patients) OD. Pharmacokinetic sampling was performed on days 1 and 15. Although at 400 mg OD only 1 patient had a grade 3 diarrhoea, 3 out of 6 patients interrupted treatment early due to a combination of various grade 1-3 toxicities (diarrhoea, uremiacreatinine, asthenia, vomiting, weight loss) indicating that this dose was not tolerable for a prolonged period of time. At 300 mg OD, the same pattern of toxicities was observed, but all were grade 1-2. Therefore, this dose can be recommended for phase II studies. Pharmacokinetic analysis showed that peak plasma concentrations as well as the AUCs were dose-related, with increased parameters at day 15 compared with day 1, indicating some accumulation upon multiple dosing. Plasma half-life ranged from 5 to 9 h and appeared to increase with increasing dose. Steady state plasma concentrations were attained by day 14. A large volume of distribution at steady state suggested extensive distribution outside the plasma compartment. There is evidence of inhibition of protein prenylation in some patients after OD oral administration of SCH 66336. SCH 66336 can be safely administered using a continuous oral OD dosing regimen. The recommended dose for phase II studies using this regimen is 300 mg OD.     

健脾理肠饮治疗慢性溃疡性结肠炎35例

设中药健脾理肠饮治疗组35例,西药治疗对照组30例,均用药8周。结果：治疗组总有效率82.9%;对照组总有效率66.6%。治疗组的疗效优于对照组。提示健脾理肠饮治疗慢性溃疡性结肠为有一定的疗效。     

HPLC-ELSD法测定复方氨基葡萄糖片中硫酸软骨素的含量

目的建立以蒸发光散射为检测器(ELSD)测定复方氨基葡萄糖片中硫酸软骨素的高效液相色谱分析方法。方法采用高效液相色谱法,以乙腈-水-三乙胺溶液(10∶90∶0.1)为流动相,ODS色谱柱为色谱柱,蒸发光散射检测器检测。结果硫酸软骨素在1.5~21μg范围与峰面积呈良好线性关系;该方法3个不同浓度的平均回收率分别为99.33%,98.29%,98.95%,重复性实验的RSD为0.15%。结论本方法准确、快速、重复性好。     

自我测量健康状况的新方法SRHMS运用

SRHMS作为测量健康状况的效用指标,能够从躯体、心理、社会适应三维的测量观念出发,综合性地自我评价健康状况。本文介绍和探讨了SRHMS的测量内容、测量方法以及在健康教育领域中的应用,为研究人群健康评价问题提供参考资料。     

高三学生父母养育方式与人际信任自尊的相关研究

目的探讨高三学生父母养育方式与人际信任、自尊之间的关系。方法:运用父母养育方式评价量表(EMBU)、人际信任量表(IT)和自尊量表(SES)对183名高三学生进行了调查。结果人际信任与父母的情感温暖、理解呈非常显著的正相关(r=-0.227～0.291,P<0.01);与惩罚严厉、拒绝否认、过分干涉和偏爱被试等养育方式呈负相关(r=-0.185～-0.306,P<0.05～0.01);自尊与父亲的过度保护、偏爱被试及母亲的过分干涉、保护被试等养育方式呈负相关(r=-0.148～-0.211,P<0.05～0.01);学生类别(复习生和应届生)和性别与父母的情感温暖、理解呈显著正相关(r=0.152～0.196,P<0.05～0.01),与惩罚严厉和拒绝否认呈负相关(r=-0.144～-0.196,P<0.05～0.01);出生排行越大的个体,人际信任度越高;应届生的人际信任明显高于复习生,且差异显著(P<0.01)。结论父母养育方式对高三学生的人际信任和自尊都有密切关系。