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71.
标 题 瑞典老年高血压试验中的发病率及病死率作 者 DahlofB,LindholmLH,HanssonL,etal. 参考文献 Lancet,1991,338:1281~1285研究的疾病 高血压病。目 的 是为了评估抗高血压药物治疗对70~84岁老年高血压患者的益处岁的高血压患者,基础血压≥180/90mmHg,或舒张压≥105mmHg。进入试验前12个月内有心肌梗死、脑卒中、体位性低血压及血压>230/120mmHg者已除外。随 访 随访1~4年,平均25个月。治疗方案 患者被随机安排接受药物或安慰剂治疗,药物治疗任选下列四种方案… 相似文献
72.
树突状细胞与肝脏疾病 总被引:9,自引:3,他引:6
免疫反应的产生首先是由抗原提呈细胞(antigenpresenting cells,APC)捕获抗原,经其加工处理后将抗原信息传递给T,B淋巴细胞,从而引发一系列的特异性免疫应答.APC包括树突状细胞(dendritic cells,DC)、巨噬细胞(MΦ)、B细胞等,其中DC是人体内最具潜能的抗原提呈细胞(APC),能在体内外直接激活纯真(naive)T细胞,提呈抗原给MHC-Ⅰ类限制性CD8+和MHC-Ⅱ类限制性CD4+T淋巴细胞,诱导特异性免疫应答[1-6]. 相似文献
73.
Win M Han Awachana Jiamsakul Sasisopin Kiertiburanakul Oon T Ng Benedict LH Sim Ly P Sun Kinh Van Nguyen Jun Y Choi Man P Lee Wing W Wong Adeeba Kamarulzaman Nagalingeswaran Kumarasamy Fujie Zhang Junko Tanuma Cuong D Do Romanee Chaiwarith Tuti P Merati Evy Yunihastuti Sanjay Pujari Rossana Ditangco Suwimon Khusuwan Jeremy Ross Anchalee Avihingsanon 《Journal of the International AIDS Society》2019,22(1)
74.
Regeneration of dendritic cells in aged mice 总被引:1,自引:0,他引:1
Serani LH van Dommelen Alexandra Rizzitelli Ann Chidgey Richard Boyd Ken Shortman Li Wu 《Cellular & molecular immunology》2010,7(2):108-115
Age-related thymic involution causes a decreased output of thymocytes from the thymus, thereby resulting in impairment of T cell-mediated immunity. While alterations in the T cell and non-haematopoietic stromal compartments have been described, the effects of thymic involution on thymic dendritic cells (DC) are not clearly known. Thymic DC play an essential role in shaping T cell-mediated immune responses by deleting self-reactive thymocytes to establish central tolerance and by inducing regulatory T-cell (Treg) development. It is therefore important to assess the prevalence of and alterations to thymic DC with age, as this may impact on their function. We assessed the numbers and proportions of the three distinct subsets of thymic DC in ageing mice, and showed that these subsets are differentially regulated. This is expected as thymic DC subsets have different origins of development. We further assessed the responses of thymic DC in a regenerative environment, such as that induced by sex-steroid ablation (SSA), and clearly showed that, consistent with global thymus regrowth, all three DC populations increased in numbers and regained their relative proportions to thymocytes after an initial lag period. These findings are important for the clinical translation of thymic regenerative approaches, and indicate that SSA facilitates the maintenance of critical processes such as negative selection and Treg induction through promoting thymic DC regeneration. 相似文献
75.
Head JG Storfer-Isser A O'Connor KG Hoagwood KE Kelleher KJ Heneghan AM Park ER Chaudron LH Stein RE Horwitz SM 《Clinical pediatrics》2008,47(7):670-678
Pediatric residency reforms have increased emphasis on psychosocial issues, but we do not know whether this has changed pediatricians' perceptions of barriers to addressing maternal depression. A survey of 1600 members of the American Academy of Pediatrics investigated whether training in adult mental health issues and perceived barriers to addressing maternal depression differed for current pediatric residents, pediatricians in practice <5 years, and those in practice >or=5 years. Training did not differ for respondents who were currently in training, in practice <5 years, or in practice >or=5 years. Those in practice >or=5 years reported more barriers to addressing maternal depression compared with current residents. Current residents with training in adult mental techniques reported fewer barriers to the care of maternal depression. However, in spite of residency reforms, 81% of current residents reported no training in adult mental health issues. 相似文献
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Saima Hilal Siwei Liu Tien Yin Wong Henri Vrooman Ching-Yu Cheng Narayanaswamy Venketasubramanian Christopher LH Chen Juan Helen Zhou 《Journal of cerebral blood flow and metabolism》2021,41(8):1858
To determine whether white matter network disruption mediates the association between MRI markers of cerebrovascular disease (CeVD) and cognitive impairment. Participants (n = 253, aged ≥60 years) from the Epidemiology of Dementia in Singapore study underwent neuropsychological assessments and MRI. CeVD markers were defined as lacunes, white matter hyperintensities (WMH), microbleeds, cortical microinfarcts, cortical infarcts and intracranial stenosis (ICS). White matter microstructure damage was measured as fractional anisotropy and mean diffusivity by tract based spatial statistics from diffusion tensor imaging. Cognitive function was summarized as domain-specific Z-scores.Lacunar counts, WMH volume and ICS were associated with worse performance in executive function, attention, language, verbal and visual memory. These three CeVD markers were also associated with white matter microstructural damage in the projection, commissural, association, and limbic fibers. Path analyses showed that lacunar counts, higher WMH volume and ICS were associated with executive and verbal memory impairment via white matter disruption in commissural fibers whereas impairment in the attention, visual memory and language were mediated through projection fibers.Our study shows that the abnormalities in white matter connectivity may underlie the relationship between CeVD and cognition. Further longitudinal studies are needed to understand the cause-effect relationship between CeVD, white matter damage and cognition. 相似文献
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