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Zhaohao Zeng Hong Luo Kunyu Huang Lianfang Xue Hui Liu Xiaoting Li Lu Wang Haimei Cen Wei Bi Yu Zhang 《The Journal of international medical research》2020,48(12)
Central nervous system aspergillosis (CNS-A) is a rare and fatal fungal infection. Voriconazole is the recommended treatment for CNS-A. The therapeutic effect of voriconazole is good, but its use is limited due to adverse reactions. This case report describes a 37-year-old male patient that had previously been diagnosed with acute lymphoblastic leukaemia. He had received immunosuppressive agents for 1 year following a haematopoietic bone marrow transplant. He presented with a 1-month history of left limb weakness as well as recurrent fever. Brain magnetic resonance imaging showed that he had multiple cerebral infarctions. Subsequently, he was diagnosed with CNS-A by metagenomic next-generation sequencing. Voriconazole was added to his treatment regimen, but it resulted in severe haemorrhagic cystitis and possibly bladder rupture. The dose of voriconazole was adjusted and reparative bladder surgery was undertaken immediately. Eventually, the patient was successfully treated with voriconazole and there was no recurrence of symptoms after 1 year of follow-up. Haemorrhagic cystitis is a rare adverse drug reaction associated with voriconazole use. Based on the experience with this current case, physicians should be aware of urinary tract complications with voriconazole including haemorrhagic cystitis. 相似文献
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目的了解圆斑蝰蛇咬伤患者在广州周边地区的流行病学特征,为防治圆斑蝰蛇咬伤提供依据。
方法对广州医科大学附属第一医院急诊科2014年1月1日至2018年12月31日收治的圆斑蝰蛇咬伤事件的流行病学特征进行描述性分析。采用线性相关分析的方法分析咬伤后就诊时间与咬伤后出现急性肾损伤时间的相关性。
结果5年共收治毒蛇伤1481例,死亡3例,其中43例圆斑蝰蛇咬伤,死亡2例,占毒蛇伤总死亡率的66.7%(2/3);患者分布以广州珠三角地区(肇庆、云浮、佛山、江门)伤者居多,占74.4%,9~11月是咬伤高发月份,占44.2%(19/43),被咬伤者以农民为主,占53.5%(23/43),50~69岁为主要高发年龄,下肢咬伤占67.4%(29/43),蛇伤严重程度评分重度病例占74.4%(32/43)。咬伤后就诊时间与咬伤后出现急性肾损伤的时间存在显著相关性(r=0.719,P<0.01)。
结论圆斑蝰蛇咬伤是广州周边地区毒蛇伤的主要死亡原因,应对高发月份、高发地区、高发人群及高发部位进行重点监测和干预,提高公众的自我保护能力,一旦发生圆斑蝰蛇咬伤,应立即到正规医院接受针对性诊治,必要时接受血液净化治疗。 相似文献
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Dawanna S. White Daniel Mongeluzi Alyson M. Curry Dickson Donu Yana Cen 《RSC advances》2022,12(4):2219
Adenosine and its derivatives are important building blocks of the biological system. They serve as the universal energy currency, amplify intracellular signals for various signal transduction pathways, and can also be used as the co-substrates for enzymatic transformations. The synthesis and regulation of adenosine and its analogs rely on the adenosine binding proteins (ABPs). Dysregulated ABP activity contributes to numerous diseases such as cancer, metabolic disorders, and neurodegenerative diseases. Presently, there is intense interest in targeting ABPs for therapeutic purposes. A large fraction of the human ABP family remains poorly characterized. The need for innovative chemical probes to investigate ABP function in the native biological matrix is apparent. In this study, an adenosine analog, probe 1, with a photoaffinity group and biotin tag was synthesized using concise synthetic strategies. This probe was able to label and capture individual recombinant ABPs with good target selectivity. Probe 1 was also evaluated for its ability to label spiked ABP in complex cell lysates. This chemical probe, together with the labeling and enrichment assay, is of great value to interrogate the biological functions of ABPs and to elucidate their diversity under different physiological conditions.Photoactivatable adenosine analog-enabled capture and enrichment of adenosine binding protein (ABP). 相似文献
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Jianyong Zhuo Di Lu Jianguo Wang Zhengxing Lian Jiali Zhang Huihui Li Beini Cen Xuyong Wei Qiang Wei Haiyang Xie Xiao Xu 《中国癌症研究》2021,33(4):470-479
ObjectivePatient-derived xenograft (PDX) models provide a promising preclinical platform for hepatocellular carcinoma (HCC). However, the molecular features associated with successful engraftment of PDX models have not been revealed.MethodsHCC tumor samples from 76 patients were implanted in immunodeficient mice. The molecular expression was evaluated by immunohistochemistry. Patient and tumor characteristics as well as tumor molecular expressions were compared for PDX engraftment using the Chi-square test. The independent prediction parameters were identified by logistic regression analyses.ResultsThe engraftment rate for PDX models from patients with HCC was 39.47% (30/76). Tumors from younger patients and patients with elevated preoperative alpha-fetoprotein level had higher engraftment rates. Tumors with poor differentiation and vascular invasion were related to engraftment success. The positive expression of CK19, CD133, glypican-3 (GPC3), and Ki67 in tumor samples was associated with engraftment success. Logistic regression analyses indicated that GPC3 and Ki67 were two of the strongest predictors of PDX engraftment. Tumors with GPC3/Ki67 phenotypes showed heterogeneous engraftment rates, with 71.9% in GPC3+/Ki67+ tumors, 30.8% in GPC3−/Ki67+ tumors, 15.0% in GPC3+/Ki67− tumors, and 0 in GPC3−/Ki67− tumors. ConclusionsSuccessful engraftment of HCC PDXs was significantly related to molecular features. Tumors with the GPC3+/Ki67+ phenotype were the most likely to successfully establish HCC PDXs. 相似文献
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Xu-Hui Deng Jing Li Shi-Jian Chen Yi-Ju Xie Jian Zhang Geng-Yu Cen Yi-Ting Song Zhi-Jian Liang 《World journal of gastrointestinal oncology》2021,13(12):2180-2189
BACKGROUNDThe diagnosis of both cancer and intracerebral hemorrhage (ICH) in the same patient is not uncommon, but the clinical features and pathogenesis of patients with colorectal cancer (CRC) and ICH are still not well known.AIMTo investigate the clinical features and underlying pathogenesis of ICH in patients with CRC. METHODSA retrospective review of CRC patients complicated with ICH from three centers between January 2014 and December 2020 was performed. Clinical data such as laboratory examinations, imaging features, prognosis, and underlying pathogenesis were analyzed.RESULTSOf 16673 identified CRC patients, 20 (0.12%) suffered from ICH. There were 13 males and 7 females, with an average age (mean ± SD) of 68.45 ± 10.66 years. Fourteen patients (70%) had distant metastases and most patients (85%) showed an elevation of one or more cancer biomarkers. The hemorrhagic lesions in 13 patients (65%) were in the intracerebral lobe. Four patients were completely dependent and 4 died within 30 days after hemorrhage. Intratumoral hemorrhage (50%) and coagulopathy (50%) accounted for the majority of hemorrhages.CONCLUSIONPatients with ICH and CRC often have clinical features with lobar hemorrhage, distant metastases and poor prognosis. Intratumoral hemorrhage and coagulopathy are the main causes of ICH in patients with CRC. 相似文献