A comparison of respiratory function in divers breathing with a mouthpiece or a full face mask

A comparison was made of respiratory function in submersed divers breathing with either a mouthpiece or a full face mask while exposed to varying depths (15 and 190 fsw), exercise loads (0-175 W), and static lung loads (0 and -20 cmH2O). The two types of breathing equipment were designed to be identical in terms of functional dead space volume and resistance to gas flow. When compared with data from experiments utilizing a full face mask, use of a mouthpiece caused a modest fall in expired minute volume at both depths. The majority of this decline may have been the consequence of a decrease in dead space ventilation brought about by the elimination of simultaneous nose breathing and mouth breathing. Alveolar ventilation and PETCO2 were not significantly influenced by the use of a mouthpiece, regardless of depth, workload, or static lung load. With both types of breathing gear episodes of dyspnea were infrequent during experiments with a static lung load of 0 cmH2O. Therefore, if a neutral static lung load is maintained, the type of breathing gear used does not seem to be of consequence as far as dyspnea is concerned.     

Effect of hydrophobic coating on the behavior of a hygroscopic aerosol powder in an environment of controlled temperature and relative humidity

Powders of uncoated disodium fluorescein (DF) and DF coated with various amounts of lauric or capric acids were generated as aerosols in an environment of controlled temperature and relative humidity. The particle size and distribution of these powders were characterized using a cascade impactor and a computerized data inversion method of analysis. Disodium fluorescein exhibited a hygroscopic growth ratio of 1.5 at a relative humidity of 97%. This growth was reduced to 1.3 by coating with 0.15 g of lauric acid or 0.8 g of capric acid per gram of DF, and was eliminated with 0.2 g of lauric acid or 0.18 g of capric acid per gram of DF. The reduction in hygroscopic growth probably reflects an inhibition of the growth rate. In the time following generation and prior to deposition in the collection device, approximately 40 s, the coated aerosol powders do not seem to reach their equilibrium droplet diameter. These studies indicate that these combinations of DF and fatty acid would result in larger equilibrium droplet diameters than that of the dye alone.     

Short-Ti inversion-recovery pulse sequence: analysis and initial experience in cancer imaging

Inversion recovery (IR), commonly considered a pulse sequence capable of producing T1-weighted images with excellent display of normal anatomy, is versatile: The null point and peak time provide a useful, succinct summary of the properties of IR and its capacity for producing both T1- and T2-weighted images. Shortening of the inversion time (TI) and creation of a short-TI inversion-recovery (STIR) pulse sequence increases sensitivity to malignancy and other abnormalities by making the effects of prolonged T1 and T2 on signal intensity additive and by nulling the signal from fat. The authors examined over 300 patients with various malignancies and compared STIR images with T1- and T2-weighted images obtained at 0.5 T. In 43 cases, signal-difference-to-noise ratios (SD/Ns) were calculated between tumor, fat, and muscle. In general, STIR images demonstrated tumor as a conspicuously high-intensity area in a background of muted, discernible anatomic detail. The good contrast achieved with STIR sequences between tumor and fat (SD/N = 18.1) and tumor and muscle (SD/N = 12.9) consolidated into a single image the information contained separately on T1- and T2-weighted images, which facilitates efficient detection and localization of malignancy.     

Instrument development: cardiac diet and exercise self-efficacy.

Self-efficacy has been documented as a strong predictor of health behaviors. Unfortunately, availability of reliable and valid measures of self-efficacy for a range of health behaviors is still limited. This study validated two measures of cardiac risk factor self-efficacy: the Cardiac Diet Self-Efficacy Instrument (CDSEI) and the Cardiac Exercise Self-Efficacy Instrument (CESEI). A sample of 370 cardiac rehabilitation participants provided data for principal factor analyses showing the unidimensionality of each instrument. Known groups construct validity was supported by a comparison of CDSEI and CESEI scores for cardiac rehabilitation participants and marathon runners. The value of CDSEI and CESEI scores in predicting subsequent exercise and diet performance was demonstrated with a third group of cardiac rehabilitation participants. Stability and internal consistency estimates in the .80s and .90s, respectively, support the scales' reliabilities.     

Trans-perineal implantation of radio-opaque treatment verification markers into the prostate: an assessment of procedure related morbidity, patient acceptability and accuracy.

On-line imaging of prostate markers can be used to compensate for errors in radiation delivery. This study assessed the patient acceptability and morbidity associated with the trans-perineal route of implantation. A minority experienced acute pain or bleeding. Placement was accurate in all but one subject. An operator related learning curve exists. Although this is an invasive procedure most patients found it acceptable. Implementation for routine clinical practice is feasible.     

Elevated threshold for intracortical inhibition in focal hand dystonia.

Differences between control and focal hand dystonia (FHD) subject groups in short interval intracortical inhibition (SICI) as determined by paired transcranial magnetic stimulation (TMS) can be difficult to demonstrate, due to interindividual differences. The purpose of this study was to compare two TMS methods for assessing SICI in 8 control and 7 FHD subjects. Electromyographic (EMG) data were recorded from the first dorsal interosseous (FDI) muscle of the dominant hands of the control subjects and affected hands of the FHD subjects. The first method used a conventional approach of setting conditioning stimulus intensity to 80% of rest threshold (RTh) and test stimulus intensity to 120% RTh. Three interstimulus intervals (ISIs) were used: 2 msec, 3 msec, and the ISI between 2 and 3 msec that produced optimal SICI. The second method was novel in that test stimulus intensity was set to 150% active threshold (ATh), and conditioning stimulus intensity was varied between 50% and 100% ATh. The latter was determined at the threshold for SICI and expressed as a ratio of ATh. There was no difference between the subject groups in the degree of SICI produced using the first method, at the three ISIs studied. However, using the second method, the SICI threshold:ATh ratio was found to be significantly higher for FHD subjects. This finding suggests that determining the SICI threshold:ATh ratio may be a more sensitive measure of intracortical inhibitory function than more conventional methods.