Analysis of the factors influencing the therapeutic effects of onychomycosis

From July 1 994to June 1 999,5 4 5 onychomyco-sis patients were treated with Itraconazole and com-pleted their treatment courses with complete follow-up in out- patientdepartment.The recovery rate was83.1 4% and 79.2 3% in fingernail and toenail dis-eases respectively.But following phenomena werefound:( 1 ) Some new nails stopped growing in cer-tain length,even if the treatment continued;( 2 )Some damaged nails reappeared soon after the treat-ment ceased;( 3) Some damaged nails with deep- co…     

睫状神经营养因子对应激大鼠体质量的影响及其机制探讨

①目的　探讨睫状神经营养因子 (CNTF)对躯体性和心理性应激大鼠体质量的影响及其与下丘脑促肾上腺皮质素释放激素 (CRH)含量的关系。②方法　建立应激大鼠动物模型 ,应用鼠脑立体定向方法 ,在应激前给予大鼠双侧海马微量注射CNTF ,称量大鼠应激前后的体质量变化 ,并用放射免疫分析法测定大鼠下丘脑CRH含量的变化。③结果　在应激前及应激期间给予双侧海马微量注射CNTF ,可以有效改善应激引起的大鼠体质量的下降 (t=2 .16 3.86 ,P <0 .0 5 ,0 .0 1) ,改善应激引起的下丘脑CRH含量的升高 (t=3.0 5 4.0 3,P <0 .0 1)。④结论　CNTF可以改善应激对大鼠生长的损害 ,其机制可能与CNTF降低应激大鼠下丘脑CRH的含量有关。     

Long non-coding RNA LINC01116 accelerates the progression of keloid formation by regulating miR-203/SMAD5 axis

BackgroundEmerging evidence reveals the importance of long non-coding RNAs (lncRNAs) in the development and progression of keloid formation. However, the roles and molecular mechanism of lncRNA LINC01116 in the progression of keloid formation remain largely unknown.MethodsThe expression levels of LINC01116, microRNA-203 (miR-203) and SMAD family member 5 (SMAD5) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. Cell proliferation, migration and invasion were detected by Cell counting Kit-8 (CCK-8) assay and transwell assay. Flow cytometry and western blot assay were used to examine cell apoptosis and extracellular matrix (ECM) production. The interaction between miR-203 and LINC01116 or SMAD5 was predicted by bioinformatics analysis and verified by dual-luciferase reporter and RNA Immunoprecipitation (RIP) and RNA pull-down assays.ResultsLINC01116 and SMAD5 were upregulated while miR-203 was downregulated in keloid tissues and keloid fibroblasts. LINC01116 knockdown suppressed the proliferation, migration, invasion, and ECM production but induced apoptosis in keloid fibroblasts through enhancing miR-203 and inhibiting SMAD5. Moreover, SMAD5 was identified as a direct target of miR-203 and miR-203 could directly bind to LINC01116. Besides, LINC01116 regulated SMAD5 expression by targeting miR-203.ConclusionDownregulation of LINC01116 inhibited the progression of keloid formation by regulating miR-203/SMAD5 axis, which might provide a novel target for keloid therapy.     

Risks of AKI and Major Adverse Clinical Outcomes in Patients with Severe Acute Respiratory Syndrome or Coronavirus Disease 2019

BackgroundSevere acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19) are closely related. The effect of AKI on the clinical outcomes of these two conditions is unclear.MethodsThis retrospective, territory-wide cohort study used an electronic public healthcare database in Hong Kong to identify patients with SARS or COVID-19 by diagnosis codes, virologic results, or both. The primary endpoint was a composite of intensive care unit admission, use of invasive mechanical ventilation, and/or death.ResultsWe identified 1670 patients with SARS and 1040 patients with COVID-19 (median ages, 41 versus 35 years, respectively). Among patients with SARS, 26% met the primary endpoint versus 5.3% of those with COVID-19. Diabetes mellitus, abnormal liver function, and AKI were factors significantly associated with the primary endpoint among patients with either SARS or COVID-19. Among patients with SARS, 7.9%, 2.1%, and 3.7% developed stage 1, stage 2, and stage 3 AKI, respectively; among those with COVID-19, 6.6%, 0.4%, and 1.1% developed stage 1, stage 2, and stage 3 AKI, respectively. In both groups, factors significantly associated with AKI included diabetes mellitus and hypertension. Among patients with AKI, those with COVID-19 had a lower rate of major adverse clinical outcomes versus patients with SARS. Renal function recovery usually occurred within 30 days after an initial AKI event.ConclusionsAKI rates were higher among patients with SARS than those with COVID-19. AKI was associated with major adverse clinical outcomes for both diseases. Patients with diabetes mellitus and abnormal liver function were also at risk of developing severe consequences after SARS and COVID-19 infection.     

The New Normal? Patient Satisfaction and Usability of Telemedicine in Breast Cancer Care

Annals of Surgical Oncology - Telemedicine was adopted to minimize exposure risks for patients and staff during the coronavirus disease 2019 pandemic. This study measured patient satisfaction and...     

Double hernia in continuous ambulatory peritoneal dialysis patient

Clinical and Experimental Nephrology -     

不同b值条件下心脏体素内不相干运动成像相关参数的一致性

目的观察不同b值条件下心脏体素内不相干运动(IVIM)成像相关参数的一致性。方法对30名健康志愿者行左心室中间部IVIM扫描,以双指数模型获取IVIM参数值慢速表观弥散系数(ADCslow)、快速ADC(ADCfast)及灌注分数f。比较9个b值(0、20、50、80、100、120、200、300、500 s/mm^2)与7个b值(0、20、80、100、200、300、500 s/mm^2)条件下所测参数值的差异,采用组内相关系数(ICC)分析2名医师测量参数结果的一致性,以Bland-Altman检验分析不同b值条件下所测参数的一致性。结果9个与7个b值条件下ADCslow、ADCfast及f差异均无统计学意义(P均>0.05),且2名医师测量IVIM参数的组内及组间一致性均较好(ICC均≥0.66,P均<0.05)。Bland-Altman图显示,9个与7个b值时ADCslow的平均偏差为-0.07×10-3 mm^2/s,一致性界限(-1.87,1.73);ADCfast的平均偏差1.57×10-3 mm^2/s,一致性界限(-72.64,75.77);f的平均偏差1.17%,一致性界限(-13.45,15.79)。结论9个与7个b值条件下心脏IVIM成像各参数值的一致性较好。     

Phase Transformation Behavior of the Aluminosilicate Phase During High-Pressure Hydrothermal Reduction of High-Iron Red Mud

One-step separation and recovery of sodium, aluminum and iron in high-iron red mud in a high-calcium alkaline hydrothermal system is realized by a high-pressure hydrothermal reduction process. The transformation behavior of the aluminasilica phase in high-iron red mud is mainly investigated. The results show that under the optimized conditions, a temperature of 290℃, a Na₂O concentration of 240 g/L, a calcium to silicon ratio of 3.5, and a liquid–solid ratio of 5, the Na₂O content in the transition slag is reduced to 0.12%, the dealkalization rate can reach 98%, and the alumina dissolution rate is 73%. When the starch-free reductant is added, the transition slag mainly consists of hematite and hydroandradite, and when the starch reductant is added (the addition amount is 1/4 that of ω(Fe₂O₃) in the red mud), all Fe₂O₃ in the transition slag is completely reduced to Fe₃O₄, and the main phases are magnetite and hydrogrossular.