HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms

Introduction  

Mortality from ruptured abdominal aortic aneurysms (RAAA) remains high. Severe systemic inflammation, leading to multi-organ failure, often occurs in these patients. In this study we describe the level of HLA-DR expression in a consecutive group of patients following surgery for RAAA and compare results between survivors and non-survivors. A similar comparison is made for IL-6 and IL-10 levels and Sequential Organ Failure Assessment (SOFA) scores.     

(±)-加锡果宁类似化合物的合成

天然产物加锡果宁(edulinine)具有镇痛,麻醉、抗惊厥等中枢神经抑制活性。作者在其结构基础上,采用了Topliss和Austel等的定量药物设计方法,合成了一系列加锡果宁类似化合物1V,V,并探讨了其生物作用。经药理筛选表明,个别化合物具有比加锡果宁更强的中枢神经抑制作用。     

Einsichtsrecht des Patienten in die Originalbilder

1. Der Patient hat gegen den ihn behandelnden Arzt einen Anspruch auf Einsichtnahme in die von diesem gefertigten Originalr?ntgenbilder. 2. Der Patient kann insoweit die überlassung der Originalr?ntgenbilder an den von ihm bevollm?chtigten Rechtsanwalt in dessen Kanzleibetrieb zum Zwecke der Einsichtnahme verlangen. Auf eine Einsichtnahme in den Praxisr?umen des Arztes muss sich der Patient nicht verweisen lassen. (Leits?tze der Bearbeiterin)     

Amtshaftung einer Kassenärztlichen Vereinigung

Ohne Zusammenfassung     

Aufklärungspflichtverletzung und Behandlungsfehler bei Wachheitszustand während der Operation

Ohne Zusammenfassung     

Quantification of plasma factor XIIa-Cl(-)-inhibitor and kallikrein-Cl(- )-inhibitor complexes in sepsis

Considerable evidence indicates that activation of the contact system of intrinsic coagulation plays a role in the pathogenesis of septic shock. To monitor contact activation in patients with sepsis, we developed highly sensitive radioimmunoassays (RIAs) for factor XIIa-Cl(- )-inhibitor (Cl(-)-Inh) and kallikrein-Cl(-)-Inh complexes using a monoclonal antibody (MoAb Kok 12) that binds to a neodeterminant exposed on both complexed and cleaved Cl(-)-Inh. Plasma samples were serially collected from 48 patients admitted to the intensive care unit because of severe sepsis. Forty percent of patients on at least one occasion had increased levels of plasma factor XIIa-Cl(-)-Inh (greater than 5 x 10(-4) U/mL) and kallikrein-Cl(-)-Inh (greater than 25 x 10(- 4) U/mL), that correlated at a molar ratio of approximately 1:3. Levels of factor XII antigen in plasma and both the highest as well as the levels on admission of plasma factor XIIa-Cl(-)-Inh in 23 patients with septic shock were lower than in 25 normotensive patients (P = .015: factor XII on admission; P = .04: highest factor XIIa-Cl(-)-Inh; P = .01: factor XIIa-Cl(-)-Inh on admission). No significant differences in plasma kallikrein-Cl(-)-Inh or prekallikrein antigen were found between these patients' groups. Elevated Cl(-)-Inh complex levels were measured less frequently in serial samples from patients with septic shock than in those from patients without shock (P less than .0001). Based on these results, we conclude that plasma Cl(-)-Inh complex levels during sepsis may not properly reflect the extent of contact activation.