全文获取类型
收费全文 | 310篇 |
免费 | 15篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 13篇 |
妇产科学 | 2篇 |
基础医学 | 24篇 |
口腔科学 | 11篇 |
临床医学 | 25篇 |
内科学 | 49篇 |
皮肤病学 | 5篇 |
神经病学 | 9篇 |
特种医学 | 155篇 |
外科学 | 6篇 |
综合类 | 6篇 |
预防医学 | 5篇 |
眼科学 | 1篇 |
药学 | 27篇 |
肿瘤学 | 6篇 |
出版年
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 4篇 |
2017年 | 1篇 |
2016年 | 9篇 |
2015年 | 12篇 |
2014年 | 9篇 |
2013年 | 4篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2010年 | 8篇 |
2009年 | 14篇 |
2008年 | 19篇 |
2007年 | 29篇 |
2006年 | 10篇 |
2005年 | 11篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 12篇 |
2001年 | 14篇 |
2000年 | 8篇 |
1999年 | 11篇 |
1998年 | 25篇 |
1997年 | 15篇 |
1996年 | 6篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 4篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1967年 | 1篇 |
1957年 | 4篇 |
1956年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有345条查询结果,搜索用时 15 毫秒
101.
102.
LG Hanau 《MedR Medizinrecht》2005,23(1):45-47
Abstrakt Die Gebührentatbestände Nrn. 2148, 2254 und 2258 GOÄ sind methodische Einzelschritte der operativen Zielleistung des endoprothetischen Totalersatzes des Hüftgelenks. Sie sind nicht neben Nr. 2151 abrechenbar. Die Gebührentatbestände Nrn. 2103 und 2113 GOÄ haben eigenständige Behandlungsziele und sind neben Nr. 2151 abrechenbar. (Leitsatz der Bearbeiterin) 相似文献
103.
104.
105.
KA Kaphingst FM Facio M‐R Cheng S Brooks H Eidem A Linn BB Biesecker LG Biesecker 《Clinical genetics》2012,82(5):408-415
Kaphingst KA, Facio FM, Cheng M‐R, Brooks S, Eidem H, Linn A, Biesecker BB, Biesecker LG. Effects of informed consent for individual genome sequencing on relevant knowledge. Increasing availability of individual genomic information suggests that patients will need knowledge about genome sequencing to make informed decisions, but prior research is limited. In this study, we examined genome sequencing knowledge before and after informed consent among 311 participants enrolled in the ClinSeq? sequencing study. An exploratory factor analysis of knowledge items yielded two factors (sequencing limitations knowledge; sequencing benefits knowledge). In multivariable analysis, high pre‐consent sequencing limitations knowledge scores were significantly related to education [odds ratio (OR): 8.7, 95% confidence interval (CI): 2.45–31.10 for post‐graduate education, and OR: 3.9; 95% CI: 1.05, 14.61 for college degree compared with less than college degree] and race/ethnicity (OR: 2.4, 95% CI: 1.09, 5.38 for non‐Hispanic Whites compared with other racial/ethnic groups). Mean values increased significantly between pre‐ and post‐consent for the sequencing limitations knowledge subscale (6.9–7.7, p < 0.0001) and sequencing benefits knowledge subscale (7.0–7.5, p < 0.0001); increase in knowledge did not differ by sociodemographic characteristics. This study highlights gaps in genome sequencing knowledge and underscores the need to target educational efforts toward participants with less education or from minority racial/ethnic groups. The informed consent process improved genome sequencing knowledge. Future studies could examine how genome sequencing knowledge influences informed decision making. 相似文献
106.
Bone marrow stromal cells appear to be key regulatory elements in hematopoiesis and lymphopoiesis. These stromal cells respond to cytokine exposure and alter their pattern of hematopoietic growth factor production, suggesting a degree of functional plasticity. We examined the effect of two cytokines, interleukin-1 (IL-1) and IL-4, on stromal cell regulation of pre-B cell generation using the bone marrow stromal cell line, S17. Neither lymphokine potentiated pre-B cell generation in the absence of stromal cells. However, addition of either 10 U/mL rIL-1 alpha or 50 U/mL rIL-4 to cultures of bone marrow cells containing S17 cells dramatically suppressed subsequent pre-B cell formation. Preculture of S17 stromal cells with either rIL-1 or rIL-4 completely abrogated their ability to support pre-B cell generation in subsequent coculture with freshly explanted bone marrow cells. Conditioned medium from IL-1- or IL-4-treated S17 cells also suppressed pre-B-cell generation in culture. Although it is not yet known which induced stromal cell factors are responsible for failure of pre-B-cell generation in treated cultures, these data do clearly demonstrate that local levels of IL-1 and IL-4 in the hematopoietic microenvironment may play a significant role in regulation of bone marrow stromal cell function. These data also demonstrate that fibroblastic stromal cells are primary target cells that respond to cytokine concentration and affect lymphopoietic cell development. 相似文献
107.
108.
Said SAM de Voogt WG Bulut S Han J Polak P Nijhuis RLG op den Akker JW Slootweg A 《World journal of cardiology》2014,6(4):196-204
AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. 相似文献
109.
人脑动静脉畸形中VEGF的表达变化 总被引:2,自引:0,他引:2
目的 :探讨 VEGF在脑动静脉畸形的变化。方法 :14例 AVMs行显微外科手术切除 AVMs和 AVMs周围脑组织、 8例正常脑血管和脑组织标本 ,分别提取总 RNA。 RNA狭逢斑点杂交检测 VEGF在脑 AVMs中的改变。结果 :与正常脑血管相比 ,AVMs、 AVMs周围脑组织 VEGF m RNA表达增高 ;结论 :VEGF可能与脑 AVMs的发生发展有关。 相似文献
110.