下腔静脉滤器植入术在防治肺动脉栓塞中的应用

目的 探讨下腔静脉滤器植入术在防治肺动脉栓塞中的价值。方法 回顾性分析1998年8月—2003年6月间实施的61例下腔静脉滤器植入术防治肺动脉栓塞的临床资料。结果 临时性下腔静脉滤器植入11例，永久性下腔静脉滤器50例。随访3～66个月，平均38个月。61只下腔静脉滤器均展开良好，有1例临时滤器移位至下腔静脉近心端，其他无移位。临时滤器体内置放时间2～4周取出。1例永久性滤器植入14个月后滤器中血栓形成。均未再发生肺动脉栓塞。结论 下腔静脉滤器植入术确能有效预防肺动脉栓塞，但应严格掌握适应症。     

嗅觉功能障碍首发抑郁症患者的弥散张量成像研究

目的 探讨首发抑郁症患者是否合并嗅觉功能障碍,利用弥散张量成像(diffusion tensor imaging,DTI)技术研究嗅觉功能障碍首发抑郁症患者脑白质结构改变及其与抑郁严重程度的相关性.方法 选取本院2016年4月至2017年6月首发抑郁症患者37例为研究组,同期性别、年龄及受教育程度相匹配的志愿者38例为对照组,均进行24项汉密尔顿抑郁量表(24-item Hamilton depression rating scale,HDRS24)评分;比较两组嗅觉测试结果的差异.根据嗅觉测试结果,将研究组中17例嗅觉减退的首发抑郁症患者列为研究A组,20例无嗅觉减退的首发抑郁症患者为研究B组,分别对研究A组及研究B组进行DTI扫描,运用基于纤维束示踪的空间统计分析方法(tract-based spatial statistics,TBSS)得到各向异性分数(fractional anisotropy,FA),比较研究A组与研究B组的颅脑FA值差异.结果 与对照组比较,首发抑郁症患者嗅觉测试值降低(P＜0.01);与研究B组比较,研究A组左侧海马、胼胝体膝部FA值降低(P＜0.01,FDR校正),未发现FA值显著增加区域.研究A组嗅觉测试值与HDRS24量表评分呈负相关(r=-0.519,P=0.033),左侧海马、胼胝体膝部下降的FA值与HDRS24量表评分无显著相关性(r左侧海马=0.163,r胼胝体膝部=-0.104;P ＞0.05).结论 首发抑郁症患者可合并嗅觉功能障碍;嗅觉功能障碍首发抑郁症患者存在相关嗅觉通路的损害,但FA值下降与抑郁严重程度无显著相关性.     

急性胰腺炎患者血清二胺氧化酶及D-乳酸水平与肠道功能的关系

目的 分析急性胰腺炎(AP)患者二胺氧化酶(DAO)及D-乳酸(D-LA)水平与肠道功能的关系.方法 选取2019年1月至2020年3月该院急诊医学科收治的A P住院患者60例,其中轻症34例,中度重症18例,重症8例.另选取健康体检者40例作为对照组.分别比较D A O及D-L A水平,观察患者肠道功能恢复情况.结果 AP组血清DAO和D-LA水平明显高于对照组(P<0.01);重症AP患者肠道功能恢复前血清DAO及D-LA水平明显高于中度重症及轻症患者(P<0.05),重症AP患者肠道功能恢复时间长于轻症及中度重症患者,差异均有统计学意义(P<0.05).结论 病情越重的AP患者肠道恢复时间越长,血清DAO与D-LA水平越高,监测血清DAO与D-LA水平有利于判断AP的治疗效果和预后.     

基于抗耐药性细菌感染的抗菌肽研究进展

随着抗生素的发现及滥用,耐药细菌感染已威胁到了人们的健康,现有抗生素已不能满足临床治疗的需求。因此,解决这一问题已迫在眉睫。本文针对耐药细菌的耐药机制及抗菌肽(antimicrobial peptides,AMPs)这一新型广谱抗菌药物的研究进展进行了综述。     

分泌型凋亡相关蛋白1的研究进展

分泌型凋亡相关蛋白1（ secreted apoptosis-related protein1,SARP1）,又名分泌型卷曲相关蛋白2（secretedfrizzled—related protein2,SFRP2）,最早报道于1997年。研究者发现其功能与肿瘤及创面修复关系密切,现就SARP1目前的有关研究,在此做一综述。     

Ⅰ期修补腹裂的早期转归(附18例报告)

目的 :评价Ⅰ期修补腹裂的早期转归。方法 :回顾分析我院小儿外科 17年间收治的腹裂病历 18份。结果 :产前诊断 16例 (89% )。全部病婴I期修补腹壁缺损。出生至手术的平均时间 5h(0 .5h～ 17h)。 4例合并肠道畸形和 1例并发肠坏死者需要更多的手术和更长的时间达到完全喂养 (P<0 .0 1)。 3例死亡 (16 .6 % ) ,其中 2例死于感染。结论 :我们的经验提示腹裂的死亡率不超过 16 .6 % ,降低死亡率主要是防治感染并发症 ,Ⅰ期修补可改善早期转归。     

Halogen-free instinct flame-retardant waterborne polyurethanes: composition,performance, and application

Ideal halogen-free instinct flame-retardant waterborne polyurethanes have high flame-retardant efficiency, environmental friendliness, fine compatibility, and good thermostability. Phosphorus flame-retardants are currently widely used in halogen-free instinct flame-retardant waterborne polyurethanes (HIFWPU), especially those with phosphorous–nitrogen co-structures. Phosphorous–nitrogen HIFWPU have become a hotspot because their co-structures provide higher flame-retardance as compared to waterborne polyurethanes. This review introduces three main types of HIFWPU based on composition, performance and application. HIFWPU not only have improved flame-retardance but also satisfy the various requirements for functionality. HIFWPU have been widely developed in textile, furniture, automobile, and aerospace applications.

Ideal halogen-free instinct flame-retardant waterborne polyurethanes have high flame-retardant efficiency, environmental friendliness, fine compatibility, and good thermostability.     

Biomarkers of connective tissue disease‐associated interstitial lung disease in bronchoalveolar lavage fluid: A label‐free mass spectrometry‐based relative quantification study

BackgroundThe pathogenesis of connective tissue disease‐associated interstitial lung disease (CTD‐ILD) is unclear. This study aims to identify differentially expressed proteins (DEPs) in CTD‐ILD to determine the potential role of these DEPs that may play in the pathogenesis of CTD‐ILD and to offer potential therapeutic targets.MethodsBronchoalveolar lavage fluid (BALF) samples were collected from four patients with CTD‐ILD and four patients without CTD‐ILD. Label‐free mass spectrometry‐based relative quantification was used to identify the DEPs. Bioinformatics were used to determine the potential biological processes and signaling pathways associated with these DEPs.ResultsWe found 65 upregulated DEPs including SFTPD, CADM1, ACSL4, TSTD1, CD163, LUM, SIGLEC1, CPB2, TGFBI and HGD, and 67 downregulated DEPs including SGSH, WIPF1, SIL1, RAB20, OAS3, GMPR2, PLBD1, DNAJC3, RNASET2 and OAS2. The results of GO functional annotation for the DEPs showed that the DEPS were mainly enriched in the binding, cellular anatomical entity, cellular processes, and biological regulation GO terms. The results of KEGG analyses showed that the pathways most annotated with the DEPs were complement and coagulation cascades, metabolic pathways, pathways in cancer, and PPAR signaling pathway. COG analyses further informed the functions associated with these DEPs, with most focused on signal transduction mechanisms; posttranslational modification, protein turnover, chaperones; intracellular trafficking, secretion, and vesicular transport; amino acid transport and metabolism; and lipid transport and metabolism.ConclusionsDEPs identified between patients with vs. without CTD‐ILD may play important roles in the development of CTD‐ILD and are potential new biomarkers for early diagnosis of CTD‐ILD.     

Electrochemical Evaluation of Stress Corrosion Cracking Susceptibility of Ti-6Al-3Nb-2Zr-1Mo Alloy Welded Joint in Simulated Deep-Sea Environment

Titanium alloys have high specific strength and excellent corrosion resistance and have been applied in deep-sea engineering fields. However, stress corrosion cracking may become one of the biggest threats to the service safety of a high-strength titanium alloy, as well as its weldment. In this work, stress corrosion cracking of a gas-tungsten-arc-welded Ti-6Al-3Nb-2Zr-1Mo (Ti6321) alloy influenced by the applied potentials in simulated deep-sea and shallow-sea environments was investigated by combining slow strain rate testing with electrochemical measurements. The results showed that the service environment and applied potential have a substantial effect on the stress corrosion cracking behavior of the Ti6321 welded joint. The Ti6321 welded joint exhibited higher stress corrosion susceptibility in a simulated deep-sea environment and at a strong polarization level owing to the diminishing protection of the passive film under passivation inhibition and the enhancement of the hydrogen effect. The fracture of a Ti6321 welded joint in the weld material could be attributed to the softening effect of the thick secondary α within the coarse-grained martensite. The electrochemical evaluation model of stress corrosion cracking susceptibility of a Ti6321 welded joint in a simulated marine environment was established by adding the criterion in the passivation region based on the literature model, and four potential regions corresponding to different stress corrosion cracking mechanisms were classified and discussed. Our study provides useful guidance for the deep-sea engineering applications of Ti6321 alloys and a rapid assessment method of stress corrosion risk.     

过氧化物增殖体活化受体α／γ双重激动剂的研究进展

过氧化物增殖体活化受体（PPAR）是治疗2型糖尿病等人类代谢疾病的新靶点。与单一的PPARγ激动剂相比，PPARα／γ双重激动剂可以产生协同作用，更具有开发潜力，是更好的2型糖尿病药物。现综述α-烷氧基苯基丙酸类、苯氧异丁酸类、苄基丙二酸衍生物类及其它类型的PPARα／γ双重激动剂的研究进展。并提出一些研究思路。