全文获取类型
收费全文 | 3618篇 |
免费 | 391篇 |
国内免费 | 274篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 16篇 |
妇产科学 | 62篇 |
基础医学 | 455篇 |
口腔科学 | 129篇 |
临床医学 | 459篇 |
内科学 | 539篇 |
皮肤病学 | 41篇 |
神经病学 | 182篇 |
特种医学 | 100篇 |
外国民族医学 | 2篇 |
外科学 | 316篇 |
综合类 | 596篇 |
现状与发展 | 3篇 |
预防医学 | 284篇 |
眼科学 | 88篇 |
药学 | 481篇 |
2篇 | |
中国医学 | 224篇 |
肿瘤学 | 278篇 |
出版年
2024年 | 10篇 |
2023年 | 61篇 |
2022年 | 146篇 |
2021年 | 208篇 |
2020年 | 140篇 |
2019年 | 140篇 |
2018年 | 146篇 |
2017年 | 132篇 |
2016年 | 145篇 |
2015年 | 183篇 |
2014年 | 204篇 |
2013年 | 167篇 |
2012年 | 268篇 |
2011年 | 271篇 |
2010年 | 164篇 |
2009年 | 119篇 |
2008年 | 164篇 |
2007年 | 179篇 |
2006年 | 192篇 |
2005年 | 169篇 |
2004年 | 109篇 |
2003年 | 95篇 |
2002年 | 86篇 |
2001年 | 90篇 |
2000年 | 99篇 |
1999年 | 108篇 |
1998年 | 63篇 |
1997年 | 85篇 |
1996年 | 55篇 |
1995年 | 41篇 |
1994年 | 35篇 |
1993年 | 27篇 |
1992年 | 32篇 |
1991年 | 37篇 |
1990年 | 28篇 |
1989年 | 23篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 9篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 1篇 |
1979年 | 3篇 |
排序方式: 共有4283条查询结果,搜索用时 15 毫秒
101.
Xiao-Jie Bian Yao Zhu Yi-Jun Shen Jin-You Wang Chun-Guang Ma Hai-Liang Zhan Bo Dai Shi-Lin Zhang Xu-Dong Yao Ding-Wei Ye 《Asian journal of andrology》2013,15(5):679-684
Based on the results of TAX 327, a nomogram was developed to predict the overall survival of metastatic castration-resistant prostate cancer (mCRPC) after first-line chemotherapy. The nomogram, however, has not been validated in an independent dataset, especially in a series out of clinical trials. Thus, the objective of the current study was to validate the TAX 327 nomogram in a community setting in China. A total of 146 patients with mCRPC who received first-line chemotherapy (docetaxel or mitoxantrone) were identified. Because clinical trials are limited in mainland China, those patients did not receive investigational treatment after the failure of first-line chemotherapy. The predicted overall survival rate was calculated from the TAX 327 nomogram. The validity of the model was assessed with discrimination, calibration and decision curve analysis. The median survival of the cohort was 21 months (docetaxel) and 19 months (mitoxantrone) at last follow-up. The predictive c-index of the TAX 327 nomogram was 0.66 (95% CI: 0.54-0.70). The calibration plot demonstrated that the 2-year survival rate was underestimated by the nomogram. Decision curve analysis showed a net benefit of the nomogram at a threshold probability greater than 30%. In conclusion, the present validation study did not confirm the predictive value of the TAX 327 nomogram in a contemporary community series of men in China, and further studies with a large sample size to develop or validate nomograms for predicting survival and selecting therapies in advanced prostate cancer are necessary. 相似文献
102.
Lesions involving the ampulla of Vater are rare entities (0.1–0.2 %) with high malignant potential (90 %) [1]. As a treatment, the surgical procedure known as duodenopancreatectomy was the main option, whatever the tumor’s stage or nature. Yet with improvements of endoscopic diagnostic and therapeutic techniques, management of these lesions has been modified, enabling endoscopic removal of adenoma and adenocarcinoma-in situ. Thus, when endoscopic treatment is not possible, surgical ampullectomy is still an alternative option to duodenopancreatectomy [1, 2]. The continuous improvements in surgical techniques and instruments now allow the safe realization of laparoscopic ampullectomy, despite the few cases described in the literature [3, 4]. Here we present a surgical technique in a 52-year-old patient with an ampulloma. The ampulloma was discovered during a gastroscopy for abdominal pain. The endoscopic ultrasound with biopsy revealed a 15-mm adenoma with moderate-grade dysplasia. The thoracoabdominal CT scan was normal. The procedure was performed as shown. The tumor histology showed a R0 resection (5-mm surgical margin) of an adenoma with focal high-grade dysplasia. At 3-year follow-up, outcomes were unremarkable, without any complications. 相似文献
103.
Coexistence of brain tumor and intracranial aneurysm was previously considered as an uncommon phenomenon. Actually it is not rare in neurosurgical procedures, and its incidence rate may be underestimated. Furthermore, there remains a lack of consensus regarding numerous aspects of its clinical management. We performed a retrospective study of 12 cases of coexistent brain tumor and intracranial aneurysm in our database. Then a systematic PubMed search of English-language literature published between 1970 and 2012 was carried out using the keywords: “brain tumor” and “intracranial aneurysm” in combination with “associate” or “coexist.” A consensus panel of neurosurgeons, anesthetists, interventional neurologists, and intensivests reviewed this information and proposed a treatment strategy. In the majority of patients, clinical symptoms were caused by tumor growth, whereas aneurysm rupture was seen only in a few cases. Meningioma was the commonest tumor associated with aneurysm. In most patients, both lesions occurred within the adjacent area. Treatment of both pathologies in one session was performed in most patients. All of our patients were alive within the period of follow-up. Coexistence of brain tumor and intracranial aneurysm may be a coincidence. The treatment strategy should be designed according to the conditions of tumor and aneurysm, locations of both lesions, and pathologic nature of tumor. 相似文献
104.
David A. Kooby MD Theresa W. Gillespie PhD MA Yuan Liu PhD Johnita Byrd-Sellers MS Jerome Landry MD John Bian PhD Joseph Lipscomb PhD 《Annals of surgical oncology》2013,20(11):3634-3642
Purpose
The impact of adjuvant radiotherapy for pancreatic adenocarcinoma (PAC) remains controversial. We examined effects of adjuvant therapy on overall survival (OS) in PAC, using the National Cancer Data Base (NCDB).Methods
Patients with resected PAC from 1998 to 2002 were queried from the NCDB. Factors associated with receipt of adjuvant chemotherapy (ChemoOnly) versus adjuvant chemoradiotherapy (ChemoRad) versus no adjuvant treatment (NoAdjuvant) were assessed. Cox proportional hazard modeling was used to examine effect of adjuvant therapy type on OS. Propensity scores (PS) were developed for each treatment arm and used to produce matched samples for analysis to minimize selection bias.Results
From 1998 to 2002, a total of 11,526 patients underwent resection of PAC. Of these, 1,029 (8.9 %) received ChemoOnly, 5,292 (45.9 %) received ChemoRad, and 5,205 (45.2 %) received NoAdjuvant. On univariate analysis, factors associated with improved OS included: younger age, higher income, higher facility volume, lower tumor stage and grade, negative margins and nodes, and absence of adjuvant therapy. On multivariate analysis with matched PS, factors independently associated with improved OS included: younger age, higher income, higher facility volume, later year of diagnosis, smaller tumor size, lower tumor stage, and negative tumor margins and nodes. ChemoRad had the best OS (hazard ratio 0.70, 95 % confidence interval 0.61–0.80) in a PS matched comparison with ChemoOnly (hazard ratio 1.04, 95 % confidence interval 0.93–1.18) and NoAdjuvant (index).Conclusions
Adjuvant chemotherapy with radiotherapy is associated with improved OS after PAC resection in a large population from the NCDB. On the basis of these analyses, radiotherapy should be a part of adjuvant therapy for PAC. 相似文献105.
106.
107.
70岁以上住院老年慢性病病人抑郁和焦虑的调查 总被引:1,自引:0,他引:1
随着医学科学技术的飞速发展和人民物质精神生活水平的日益提高,我国人口的平均预期寿命不断增长,现已接近70岁。据统计:目前我国老年病人口(我国以60岁以上为老年病人)总数已近I.3亿,约占总人口数的10.09%,而75岁以上老年病人以每年平均3.62%的速度增长,预测到2025年将上升到20%,2050年将达到顶峰25.5%。老年人是慢性病的主要患病人群。因此,本研究针对70岁以上患慢性病的住院普通老年人和住院离休干部进行调查,采用Brink老年抑郁量表(GDS)、Zung焦虑自评量表(SAS),以了解住院老年人中存在的焦虑、抑郁情况以及分析两组病人的性别、年龄、文化程度、婚姻状况、个人习惯和经济收入情况。现将结果报道如下。[第一段] 相似文献
108.
目的 探讨常规超声、超声造影微血管增强显像及两者联合对乳腺恶性病变的诊断价值.方法 收集152例乳房单发肿块病例,术前行常规超声、超声造影微血管增强显像,术后均行常规病理检查,通过与术后病理对照,分析常规超声、超声造影微血管增强显像及两者联合对乳腺恶性病变诊断的敏感性、特异性、阴性预测值、阳性预测值、准确性,ROC曲线下面积、95%可信区间.结果 超声造影微血管增强显像较常规超声在诊断敏感性、特异性、阳性预测值、阴性预测值、准确性上均有不同程度的提高(P =0.002),而两者联合又较单一检查更能提高恶性肿瘤的检出率(常规超声同两者联合比较,P =0.002;超声造影同两者联合比较,P =0.000),增加了ROC曲线下面积(P =0.000).结论 常规超声和超声造影微血管增强显像联合,具有很好的优势互补性,可提高乳腺恶性肿瘤的早期检出率. 相似文献
109.
110.
Bin Liang Xin Wang Yunfei Bian Huiyu Yang Ming Liu Rui Bai Zhiming Yang Chuanshi Xiao 《Clinical and experimental pharmacology & physiology》2014,41(12):1023-1030
Adenosine triphosphate‐binding cassette transporter A1 (ABCA1) and ABCG1 play crucial roles in reverse cholesterol transport, and have anti‐atherosclerosis effects, and liver X receptor alpha (LXRα) can stimulate cholesterol efflux through these transporters. Angiotensin (Ang)‐(1–7) can protect endothelial cells, inhibit smooth muscle cell growth, ameliorate inflammation and exert anti‐atherosclerotic effects. In the present study, we attempted to clarify the effect of Ang‐(1–7) on expression of ABCA1 and ABCG1, and explored the role of LXRα in the regulation of ABCA1 and ABCG1 in THP‐1 macrophages that had been incubated with angiotensin‐II (AngII). Ang‐(1–7) increased ABCA1 and ABCG1 expression in a concentration‐dependent manner at both the mRNA and protein levels, promoted cholesterol efflux, and decreased cholesterol content in THP‐1 macrophages treated with AngII. Furthermore, Ang‐(1–7) upregulated the expression of LXRα in a concentration‐dependent manner in these cells. LXRα small interfering RNA, as well as the Mas receptor antagonist A‐779, completely abolished these effects of Ang‐(1–7). In summary, Ang‐(1–7) upregulates ABCA1 and ABCG1 expression in THP‐1 macrophages treated with AngII through the Mas receptor, via the LXRα pathway. This novel insight into the molecular mechanism underlying Ang‐(1–7) and AngII interaction could prove useful for developing new strategies for treatment of cardiovascular diseases. 相似文献