复合药物局部注射治疗瘢痕疙瘩临床观察

目的：观察得宝松联合5-氟尿嘧啶局部注射治疗增生性瘢痕和瘢痕疙瘩的疗效。方法：对37例增生性瘢痕和瘢痕疙瘩患者采用得宝松和5-氟尿嘧啶皮损内注射。结果：37例患者，临床治愈15例，显效21例，无效1例，总有效率为97．3％。结论：得宝松联合5-氟尿嘧啶治疗增生性瘢痕和瘢痕疙瘩疗效显著。     

关节镜下治疗胫骨平台骨折

目的 探讨关节镜下治疗胫骨平台骨折的应用价值及方法。方法 对1994年10月～2000年10月在关节镜下治疗的23例胫骨平台骨折的患进行总结分析。结果 23例经6个月～6年随访,除1例有10。内翻畸形外均复位良好,未发生感染和严重的骨关节炎,Hohl评分：优17例、良4例、中2例,优良率91．3％。结论 Sehatzker Ⅰ～Ⅵ型胫骨平台骨折关节镜撬拨复位,松质骨螺钉固定比非手术治疗在复位、固定上更可靠,可避免遗留常见的关节内伴随损伤,比常规手术治疗创伤小、恢复快,更有利于早期活动。     

医用美容胶原注射的临床疗效观察

目的 评估胶原注射矫治皮肤缺陷的效果。方法 对不同种类的皮肤缺陷注射医用美容胶原。结果 用胶原注射矫治皮肤缺陷共103例,近期效果优良率为85．5％,未见严重并发症。结论 胶原注射矫治皮肤缺陷的方法安全、简便、有效。     

应用双指腹皮瓣重建先天性全并指分指后的甲廓

目的 介绍一种先天性全并指分指时重建甲廓的手术方法。方法 对15例先天性全并旨患者在分指时,利用共有末节手指掌侧皮肤形成宽、窄两块皮瓣覆盖分形后裸露的甲缘,重建甲廓。结果 所有皮瓣均成活,30个重建的甲廓中有21个外观满意,2个由宽皮瓣、7个由窄皮瓣重建者较正常的稍小。术后指腹丰满、无指甲扭曲。结论 应用双指腹皮瓣重建甲廓治疗先天性全并指可一次完成,效果满意,具有临床应用价值。     

猴下颌角截骨术后咬肌变化的影像学与肌电功能研究

目的:研究下颌角截骨术后咬肌形态与功能的变化情况。方法:12只成年雌性恒河猴分为3组,每组4只。各组经口内随机行一侧下颌角截骨术,做自身前后对照。术前及术后3、6、12个月时以CT和肌电仪动态检测术侧咬肌的厚度、横截面积和肌电电压峰值。结果:术后咬肌厚度、横截面积和肌电峰值均减小,这些变化在术后3个月最为明显,术后6个月开始恢复,但在术后12个月时仍与正常组有显著差异。结论:下颌角截除术使咬肌的形态与功能产生一定程度的萎缩与减弱,但随着时间的推移,有逐渐恢复的趋势。     

多层螺旋CT对于肝结核的诊断价值

目的探讨肝结核的多层螺旋CT表现及其诊断价值。方法收集14例经手术（5例）、穿刺活检（4例）或临床（5例）证实的肝结核患者CT资料，分析其CT表现，并与病理改变对照。结果14例肝结核可分为2种类型：①肝实质型12例。细分为4种亚型：粟粒型2例，增强扫描表现为点状稍低密度；结节型5例，平扫边界模糊，有2例环形强化，2例无强化，1例环形强化与无强化区混杂；脓肿型4例，平扫边界模糊，2例表现为云絮状淡薄强化，2例环形强化；纤维钙化型1例，钙化灶呈斑块状。②肝浆膜型2例，表现为肝包膜均匀性增厚或伴结节附着，呈轻微强化，肝包膜下局限积液。其他征象包括肝肿大和其他器官结核，如腹腔淋巴结、胰、脾、肾上腺、肠道及肺部可见结核病灶。结论螺旋CT对诊断肝结核有重要价值，一定程度上反映了肝结核不同的病理改变。     

MR淋巴显像技术显示乳糜池和胸导管的研究

目的探讨非造影性MR淋巴显像技术对正常乳糜池和胸导管的显示情况以及它们的形态特点。方法对112例接受胸部和上腹部MR检查的病例加作MR水成像序列即呼吸门控快速自旋回波(TSE)3DT2W序列以显示乳糜池和胸导管,扫描序列包括:①呼吸门控半傅立叶单次激发快速自旋回波(HASTE)T2W序列;②屏气快速小角度激发(FLASH)T1W序列;③呼吸门控TSE3DT2W(MR水成像)冠状位扫描。将其中满足纳入标准的100例作为研究对象,观察乳糜池和胸导管的显示情况、位置和形态。结果在TSE3DT2W图像上:①乳糜池显示率为71.0%(71/100),其中单管型占43.7%(31/71),分支型(2～3支淋巴管汇合)占23.9%(17/71),网状型占32.4%(23/71);乳糜池平均长度4.5cm。②胸导管下段显示率为57.0%(57/100),平均直径0.23cm。③胸导管上段显示率为31.0%(31/100)。结论作为一种无创性方法,TSE3DT2W序列能较好地显示乳糜池和胸导管下段,结合横断面HASTE和FLASH序列,可以确定这些较大淋巴管结构的位置和解剖形态。     

自身免疫性胰腺炎的CT表现特征(附4例分析)

目的探讨自身免疫性胰腺炎(AIP)的CT表现特征。方法收集4例经临床、实验室检查和类固醇激素治疗有效的AIP患者的CT资料。CT检查包括平扫、双期(动脉期和门静脉期)增强扫描,在CT图像上观察胰腺的形态、大小、质地、强化程度、胰管、胰腺边缘、胰周及腹膜后各间隙等情况并分析AIP的CT表现特征。结果3例AIP表现为胰腺弥漫性肿大,1例为胰头的局限性肿大;病变区域胰腺实质在动脉期强化减弱但出现明显的延时强化;2例在胰腺病变区周围环绕包膜样结构;2例伴胆总管胰头段狭窄,1例ERCP显示胰管不规则狭窄;经类固醇激素治疗后,CT复查显示胰腺情况明显好转。结论AIP的CT表现具有一定的特征性。     

Possible role of hydrogen sulfide on the preservation of donor rat hearts

OBJECTIVE: The aim of this study was to observe the preservative effect of hydrogen sulfide (H2S) on donor rat hearts. MATERIALS AND METHODS: The hearts of 24 Sprague-Dawley rats were perfused on a Langendorff perfusion column for 30 minutes. We calculated and recorded the left ventricular-developed pressure (LVDP), and positive and negative derivatives of left ventricular systolic pressure (LVSP; +dP/dt and -dP/dt). Hearts were then arrested and stored for 6 hours at 4 degrees C: group 1, Krebs-Henseleit (KH) solution; group 2, KH solution with 1 micromol/L NaHS; group 3, KH solution with 1 micromol/L NaHS and 10 micromol/L glibenclamide; group 4, St. Thomas II solution. Hearts were transferred back to the Langendorff column. After stabilizing for 30 minutes, LV performance was assessed as before. The donor hearts were kept for pathological study including myocardial water ratio, ATP content, and myocyte apoptosis index. RESULTS: The recovery rates of +dp/dtmax, -dp/dtmax, and LVDP of groups 2 and 4 were much better than those of groups 1 and 3. The hearts contracted immediately after reperfusion in group 4. Ventricular fibrillation was seen before contraction in the other 3 groups, with the longest duration in group. No significant difference in myocardial water ratio was found. The ATP content was the highest in group 2. Apoptosis was observed in the 4 groups with the lowest apoptosis index in group 2. CONCLUSIONS: H2S has a protective effect on rat donor hearts at the concentration of 1 micromol/L. The protective effect is better than that of St. Thomas II solution. The protective effect of H2S can be blocked by glibenclamide.     

STMN-1 Gene: A Predictor of Survival in Stage IIA Esophageal Squamous Cell Carcinoma After Ivor-Lewis Esophagectomy?

Background

Prognosis of esophageal squamous cell carcinoma (ESCC) is stage-specific; however, some patients with the same stage have different survival outcomes. Clinically, it is significant to explore the biological marker to predict patient’s outcome. We investigated the association between the stathmin1 gene (STMN-1) expression and the prognosis of patients who underwent Ivor-Lewis esophagectomy.

Methods

A total of 162 patients who suffered from midthoracic stage IIA ESCC and completely resected with Ivor-Lewis esophagectomy were studied for STMN-1 expression by qRT-PCR in fresh-frozen tissue and validated by immunohistochemistry in matched formalin fixed-paraffin embedded tissue samples. STMN-1 level was evaluated as a prognostic factor in ESCC. SPSS 21.0 software was used to analyze the relationship between STMN-1 expression and clinicopathological characteristics and survival probability.

Results

The overall 3- and 5-year survival was 72.20 and 42.00 % respectively. Ninety-four patients (58.02 %) experienced disease recurrence with a disease-free interval of 21.50 ± 1.20 months. qRT-PCR result showed that STMN-1 mRNA level in patients who were alive at the end of follow-up was lower compared with patients who died during the follow-up period (p < 0.05). Immunohistochemical results showed that 94 patients had STMN-1 protein overexpression (58.02 %), patient with STMN-1 overexpression had worse survival compared with patients who had low STMN-1 expression (p = 0.00). Cox regression analysis revealed that STMN-1 protein expression and T classification are independent prognostic factors.

Conclusions

Even localized ESCC are potential to relapse with poor prognosis. This study demonstrates that STMN-1 level is an independent prognostic factor after Ivor-Lewis esophagectomy. In addition, assessment of STMN-1 level could improve stratification of stage IIA ESCC patients.