Circulating biomarkers for detection of ovarian cancer and predicting cancer outcomes

Background:

Securing a diagnosis of ovarian cancer and establishing means to predict outcomes to therapeutics remain formidable clinical challenges. Early diagnosis is particularly important since survival rates are markedly improved if tumour is detected early.

Methods:

Comprehensive miRNA profiles were generated on presurgical plasma samples from 42 women with confirmed serous epithelial ovarian cancer, 36 women diagnosed with a benign neoplasm, and 23 comparably age-matched women with no known pelvic mass.

Results:

Twenty-two miRNAs were differentially expressed between healthy controls and the ovarian cancer group (P<0.05), while a six miRNA profile subset distinguished presurgical plasma from benign and ovarian cancer patients. There were also significant differences in miRNA profiles in presurgical plasma from women diagnosed with ovarian cancer who had short overall survival when compared to women with long overall survival (P<0.05).

Conclusion:

Our preliminary data support the utility of circulating plasma miRNAs to distinguish women with ovarian cancer from those with a benign mass and identify women likely to benefit from currently available treatment for serous epithelial ovarian cancer from those who may not.     

中耳炎颞骨咽鼓管峡部粘-软骨膜的组织病理学观察

目的：了解中耳炎性病咽鼓管峡部粘－软骨膜的影响。方法：用光镜对３２耳各型中耳炎颞骨（中耳炎组）与５０耳正常颞骨（正常组）标本连续切片的咽这峡部粘－软骨膜,中耳腔鼓岬粘骨组织病理学比较观察。结果：中耳炎组和正常组颞骨标本咽鼓管峡部均无病理性阻塞;中耳炎组峡部粘－软骨膜厚度测量和病理观察,未见有明显炎症改变,与正常组比较无明显差异;而其中耳腔粘骨膜均明显炎症病变。这种炎症截然不同反应的界限恰好在咽这的     

Oral rehydration with a plantain flour-based solution in children dehydrated by acute diarrhea: a clinical trial

A clinical trial was conducted in order to prove the efficacy of a solution containing 50 g/1 of plantain flour and 3. 5 g/1 of sodium chloride (NaCl) for the rehydration of children with acute diarrheal diseases. 121 children were given WHO-ORS (Group A) and 117 a plantain flour-based solution (Group B). Rehydration was successful in 85. 9% in Group A and 88. 0% in Group B ( p = 0. 634). Rehydration was completed in 5. 28 h (SD 1. 99) in Group A and in 4. 88 h (SD 2. 11) in Group B ( p = 0. 132). The average solution intake for rehydration was 24. 56ml/kg/h (SD 10. 12) in Group A and 21. 17ml/kg/h (SD 9. 35) in Group B ( p = 0. 00782). The mean stool output during rehydration was 8. 45g/kg/h (SD 9. 72) in Group A and 4. 69 g/kg/h (SD 4. 98) in Group B ( p = 0. 00053). Decrease in blood levels of sodium and potassium occurred in some children in group B. The plantain flour-based solution proved effective for the treatment of dehydration due to acute diarrheal diseases and should be considered as an alternative when standard WHO-ORS is not available.