Children at risk: Performance of three-year-olds and their mentally ill and well mothers on an interaction task

Fifteen mothers previously hospitalized for mental illness (psychosis) and 15 well mothers were observed with their 3-year-old children. While mentally ill mothers expressed less positive affect than well mothers, there were no other respects in which the two groups of mothers and their children differed. There were differences in the pattern of intercorrelations among these interaction variables between the two groups, which appear to reflect differences in the degree of flexibility between mothers in the two groups.The authors wish to thank Jana Marvis and Iris Polivy for their help in coding the interaction data, and Drs. Carol Hartman, Justin Weiss, Freda Rebelsky, and Edward Mueller for their comments regarding an earlier draft of this paper. This research was supported in part by Grant MH-19,146 from the National Institute of Mental Health.     

Mechanics of Avian Fibrous Periosteum: Tensile and Adhesion Properties During Growth

We report the results of direct mechanical tests of the fibrous periosteum from the tibiotarsi of white leghorn chicks at 4, 6, 8, 9, 10, 11, 12, and 14 weeks of age using a newly developed sample isolation technique. Additionally, this technique allows the determination of the apparent in vivo load on the fibrous periosteum. The periosteum has a highly nonlinear stress-strain relationship at all ages. For loading below the in vivo level, the periosteum is pliant and mean tensile modulus is 3.35 MPa (±1.84 SD, n = 75). For loading above the in vivo level, tensile stiffness is nearly two orders of magnitude greater. In the region of high stiffness, mean modulus is 229.5 MPa (±89.6, n = 72). In vivo, the periosteum is loaded at the transition between these two stiffness regions. We interpret this as indicating that, in vivo, the collagen fibers of the periosteum are aligned, but subject to minimal loading. Stress levels in the periosteum corresponding to in vivo conditions indicate modest loading, and mean apparent in vivo stress levels are 0.92 MPa (±0.37 SD, n = 67). A second technique demonstrated that the adhesion of the periosteum in the diaphyseal region (1–6 weeks of age) is minimal, but is substantial in the metaphyseal region. The metaphyseal adhesion will affect the transmission of load between the physes. These studies suggest that growth of the fibrous periosteum follows the longitudinal growth of the bone, rather than the periosteum having a direct mechanical influence on growth plate activity. Comparison of tensile properties over the course of growth indicates a substantial increase in periosteal stiffness in the early portion of the growth period, which reaches a maximum at approximately 9 weeks posthatching. There is also a marked decline in periosteal stiffness as growth rate declines in the latest stages of growth (14 weeks). This suggests that the basic properties of periosteal collagen may undergo a transition during the course of this tissue’s brief functional lifetime; that is, during long bone growth.     

Estradiol treatment decreases type A and increases type B monoamine oxidase in specific brain stem areas and cerebellum of ovariectomized rats

Diurnal variations in activities of both type A and type B monoamine oxidase (MAO) in specific areas of the brain stem were investigated in male rats maintained on a 12 h light-12 h dark schedule (06.00 to 18.00 h light). A significant diurnal variation in the activity of both type A and type B MAO was observed in the areas A₁, A₂ and in the locus coeruleus, but not in the cerebellar cortex. For both type A and type B MAO lowest activities were found during the morning, while highest activities occurred in the late afternoon and the beginning of the night. These results may reflect a role of MAO in the circadian variation of the concentrations of catecholamines in the brain stem.     

Reaktionen von Diphenylcarbinolen mit Phosphorsäure

Reactions of Diphenylcarbinols with Phosphoric Acid In contrast to the reaction of 1,1-diphenyl-2-methyl-2-aminopropanol-(1) (1) with phosphoric acid to 2-amino-2-(9-fluoreno)-propane (2) , no analogous reaction is observed with various 1,1-diphenylcarbinols; rearrangement and elimination reactions are found. The products of these reactions are investigated mainly by NMR- and mass spectrometry.     

Epstein-Barr virus-related lymphocyte stimulation inhibitor: a possible prognostic tool for undifferentiated nasopharyngeal carcinoma

It is demonstrated in this study that a serum factor, a lymphocyte stimulation inhibitor (LSI), which inhibits Epstein-Barr virus (EBV)-induced lymphocyte stimulation, is a potentially useful tool in the diagnosis and monitoring of nasopharyngeal carcinoma (NPC). In a study of 25 patients with undifferentiated NPC, 20 healthy controls, and 20 patients with other head and neck tumors, LSI was found only in the NPC patients with active disease. In a more complete study of 8 patients longitudinally followed up for at least 20 months, a comparison of LSI with antibodies to a variety of EBV antigens including viral capsid antigen, early antigen, and nuclear antigen indicated that LSI levels provided a reliable and sensitive indicator of disease activity that should be added to clinical markers currently in use as monitors of disease activity in NPC.