Cardioprotective effect of Chinese herbal medicine for anthracycline-induced cardiotoxicity in cancer patients: A meta-analysis of prospective studies

Background:To assess the benefits and harmful effects of Chinese herbal medicine (CHM) formulations in preventing anthracyclines (ANT)-induced cardiotoxicity.Method:The Cochrane Library, Pubmed and EMBASE databases were electronically searched for relevant randomized controlled trials (RCTs) published till December 2021 in English or Chinese-language, in addition to manual searches through the reference lists of the selected papers, and the Chinese Conference Papers Database. Data was extracted by 2 investigators independently.Result:Seventeen RCTs reporting 11 different CHMs were included in this meta-analysis. The use of CHM reduced the occurrence of clinical heart failure (RR 0.48, 95% CI 0.39 to 0.60, P < .01) compared to the control group. Data on subclinical heart failure in terms of LVEF values showed that CHM reduced the occurrence of subclinical heart failure (RR 0.47, 95% CI 0.35 to 0.62, P < .01) as well.Conclusion:CHM is an effective and safe cardioprotective intervention that can potentially prevent ANT-induced cardiotoxicity. However, due to the insufficient quality of the included trials, our results should be interpreted with cautious.     

Gingival metastasis from primary hepatocellular carcinoma: a case report

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide; however, cases with metastasis to the oral cavity are extremely rare. Herein, we report a 68-year-old man who was diagnosed with HCC. Ten months after surgical removal of the right half of his liver, the patient developed gingival metastasis. Unfortunately, the patient died 4 months after the diagnosis. We discuss treatment options, pathological results, and disease prognosis. When a mandibular gingival mass is found, metastatic tumors should be considered in the differential diagnosis. In this regard, the patient’s medical history and physical examination are valuable indicators for the diagnosis of mandibular gingival metastasis. This case provides a basis for the clinical diagnosis of metastatic HCC involving the oral cavity.     

30 d-6°头低位卧床对人下肢脂肪体积的影响

目的 观察模拟失重对人下肢脂肪体积的影响,验证磁共振水脂分离成像技术在测量人下肢脂肪容积中的可行性.方法 14名男性健康志愿者,-6°头低位卧床30 d,使用磁共振水脂分离成像(Dixon)技术采集卧床前后的下肢横断面解剖图像,测量卧床前后下肢脂肪体积.结果 与卧床前相比,卧床后所有志愿者下肢总脂肪体积及大腿段脂肪体积显著增加(P＜0.001);小腿段脂肪体积呈增加趋势,但无统计学差异(P＞0.05).结论 使用MRI水脂分离成像可以清晰地显示卧床前后下肢脂肪体积的变化;-6°头低位卧床30 d后下肢脂肪体积明显增加.     

单孔腹腔镜子宫腺肌病病灶大部切除术临床应用

目的探讨单孔腹腔镜子宫腺肌病病灶大部切除术的可行性与安全性。 方法回顾性分析2018年3月至2020年6月在南京医科大学附属常州第二人民医院妇科接受单孔腹腔镜下子宫腺肌病病灶切除术＋子宫成形术的7例患者的临床资料并进行总结分析。 结果接受经脐单孔腹腔镜子宫腺肌病病灶大部切除术＋子宫成形术的7例患者手术均成功，术中未增加其他手术切口，无一例中转开腹手术。发生术中并发症的共2例，程度均较轻，术中及时给予相应处理，术后密切观察，恢复良好。所有患者术后恢复良好，均顺利出院，对切口愈合后的美容效果满意度高。出院后随访发现患者月经量明显减少，痛经症状明显改善，生存质量均显著提高。 结论严格把握手术适应证的情况下，单孔腹腔镜子宫腺肌病病灶大部切除术可能是安全、可行的。     

Hp感染的功能性消化不良腹痛症状与P物质、降钙素基因相关肽的关系

目的 初步探讨幽门螺杆菌(Hp)感染的功能性消化不良(FD)患者腹痛的发病机制.方法 根据罗马Ⅲ诊断标准,选择以上腹痛为临床表现的FD患者36例.胃镜下Hp快速尿素酶及C13尿素呼气试验将36例患者分为Hp(+)组(n=20)和Hp(-)组(n=16),同时选择12例健康人设立对照组.免疫组织化学法检测P物质(SP)、降钙素基因相关肽(CGRP)在各组组织中的密度值及明确SP、CGRP在细胞中的定位.视觉模拟评分将Hp感染的FD患者腹痛程度分为轻度、中度、重度,比较SP、CGRP在不同腹痛程度患者中的平均光密度值.结果 Hp(+)组SP、CGRP的平均光密度值高于Hp(-)组(SP:0.056±0.016 vs.0.027±0.009;CGRP:0.073±0.018 vs.0.034±0.009,P＜0.05).SP、CGRP在重度腹痛患者中的平均光密度值明显高于中度腹痛者(SP:0.074士0.011 vs.0.055±0.012;CGRP:0.094±0.005 vs.0.075士0.009,P＜0.05);中度腹痛患者的平均光密度值明显高于轻度腹痛者(SP:0.055±0.012 vs.0.043±0.008;CGRP:0.075±0.009 vs.0.054±0.010,P＜0.05).显微镜下观察到CGRP位于胃窦腺上皮细胞胞质内,SP同样位于胃黏膜细胞胞质.结论 Hp感染的FD患者腹痛与SP、CGRP有关.     

不典型再生障碍性贫血120例分析

分析120例不典型再生障碍性贫血临床特点及骨髓血液学特点。作者结合文献讨论了本病的发病特点和发展规律。     

2010-2012年柳州市结核病疫情分析

目的了解柳州市近年来结核病发病以及流行状况,分析存在的影响因素,预测流行趋势,探讨防治措施。方法对2010-2012年柳州市结核病网络直报资料和病人系统管理资料进行描述性流行病分析。结果柳州市结核病疫情总体呈下降趋势（χ2=10．42,P〈0．os）,发病率平稳。男性多于女性;25～74岁年龄组占79．03％,有逐步向高年龄组发展的趋势;以农民工为主（占54．83％）;3-9月份发病较多;柳州市市区以及所辖6县均有发病,其中融安县发病率最高。结论坚持实施现代结核病控制策略（Directly Observed Treatment Short-course,DOTS政策）和结核病“三位一体”综合防治模式,加强发现、规范化治疗和全程督导管理,以有效预防和控制结核病的发生和流行。     

1例重症Goodpasture病的诊治

作者报道了１例重症Ｇｏｏｄｐａｓｔｕｒｅ病患者。患者入院时血肌酐近１３００μｍｏｌ／Ｌ，肾活检发现新月体占肾小球总数的９１．７％。经过双重血浆滤过、甲基强的松龙和环磷酚胺冲击等强化、综合治疗，患者肺出血停止，血清抗肾小球基底膜抗体转阴，但肾功能及重复肾活检病理均无改善。     

Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway

Hyperuricemia is one of the independent risk factors for atherosclerotic cardiovascular disease. Herein, we investigate the association between uric acid and cholesterol metabolism and the effect of dioscin on the prevention of hyperuricemia-induced atherosclerosis. In the potassium oxonate-treated ApoE^{−/−−/−} mice, atherosclerosis was accelerated along with elevated serum cholesterol levels in the hyperuricemic state, which can be ameliorated by dioscin. Together with the in vitro assays, we found that the effect of dioscin was at least partially through the regulation of the farnesoid X receptor (FXR) -small heterodimer partner (SHP) -7α-hydroxylase (CYP7A1) signaling pathway in the liver. Tigogenin (a metabolite of dioscin) suppressed FXR activation and increased CYP7A1, resulting in an increased conversion rate of cholesterols into bile acids. Further clinical study revealed that treatment with a dioscin-enriched preparation decreased serum cholesterol levels in individuals with hyperuricemia. In summary, this study demonstrated a slowdown effect of dioscin on the progression of hyperuricemia-induced atherosclerosis.