Effect of Cycloheximide on the Adaptive Response Induced by Low Dose Radiation

Human lymphocytes pre-exposed to 10 mGy or 50mGy of X-rays become less sensitive to subsequent large dose irradiation,exhibited lower rate of chromosome aberration than expected.This adaptive response could be inhibited by cycloheximide,a protein synthesis inhibitor for successive 2h period ranging from 0.5h before to 4h after the low dose exposure,indicating that the adaptive response was directly related with the protein synthesis.     

红毛五加多糖对机体免疫功能的影响

本文研究红毛五加多糖成分对机体免疫功能的影响,实验结果表明红毛五加多糖可激发T、B-淋巴细胞的生物学效益。     

颈外动脉主要分支的测量与观察

本文对60侧成人半头颈标本的颈外动脉主要分支进行了测量与观察。为了颞浅动脉插管(造影或化疗)及血管吻合术的需要,进一步测量了颞浅动脉与颈外动脉、颞骨颧突部的两个角度以及颞浅动脉内壁的周长,并推算出其内径。旨在为临床应用及国人体质调查提供参考资料。     

Comparative effects of ethanol on motor activity and operant behavior.

Ethanol effects on two types of motor activity and on lever responding for food delivered on a fixed-ratio 20 (FR 20) reinforcement schedule were compared using C57BL/6 (C57) mice. Low doses of ethanol (1-2 g/kg) transiently elevated horizontal activity and high doses (2.5 and 3.0 g/kg) reduced this behavior throughout testing with a slight recovery toward the end of a 16-min test period. In contrast, similar ethanol doses produced a monotonic reduction in both vertical activity and lever responding for food under the FR 20 schedule. The ethanol-induced reduction in FR 20 lever responding was less prolonged than the reduction in vertical activity but was more prolonged than the reduction in horizontal activity. Because vertical activity and lever responding for food delivered on the FR 20 schedule were never elevated, were reduced at ethanol doses that either stimulated or depressed horizontal activity, and were unaffected by low ethanol doses that did not affect horizontal activity, it is unlikely that either are sensitive to the stimulatory effects of ethanol. Accountable mechanisms for the different effects of ethanol on the three behaviors are unknown; however, the present study eliminates ethanol dose, postinjection time, testing time, and food deprivation condition as possible reasons for the differences.     

新城疫病毒W系疫苗抗小鼠移植瘤作用的实验研究

用新城疫病毒Ⅳ系疫苗免疫治疗小鼠腹水型肝癌移植瘤，结果：治疗组平均瘤重明显小于对照组（Ｐ＜０．０５）；治疗组淋巴细胞应答水平显著高于对照组（Ｐ＜０．０５）。表明新城疫病毒Ⅳ系疫苗具有抗移值瘤作用。     

五叶参抗血栓形成作用的研究

用人血进行体外实验研究证实,五叶参水煮制备液能明显抑制APD、复合诱聚剂诱导的血小板1min、5min、最大聚集率,并促进解聚发生(P均<0.05);该药还对体外血栓形成具有显著的抑制作用(P<0.05);五叶参水煮液与PPP混合后,尚能抑制多种凝血因子活性,使KPTT、PT、TT、AT、RVV-RT、RVV-CT等凝血试验时间延长(P均<0.05);此外,五叶参有加速红细胞电泳速度的作用。上述结果表明,五叶参是一种具有抑制血小板功能、凝血功能及红细胞聚集性等多个环节的抗血栓形成药物,值得进一步研究探讨。     

DOWN－REGULATION OF C－MYC ONCOGENE DURING NGF－INDUCED DIFFERENTIATION OF NEUROBLASTOMA CELL LINES

ＤＯＷＮ－ＲＥＧＵＬＡＴＩＯＮＯＦＣ－ＭＹＣＯＮＣＯＧＥＮＥＤＵＲＩＮＧＮＧＦ－ＩＮＤＵＣＥＤＤＩＦＦＥＲＥＮＴＩＡＴＩＯＮＯＦＮＥＵＲＯＢＬＡＳＴＯＭＡＣＥＬＬＬＩＮＥＳＣｈｅｎＪｉｅ（陈杰），ＬｉｕＴｏｎｇｈｕａ（刘彤华）ａｎｄＡｌｏｎｚｏＨＲｏ...     

乳腺囊性增生病癌变过程中部分因素变化的意义

检测乳腺囊性增生病（ＦＣＤ）经不典型增生到癌变部分因素的变化。结果提示：从因明显ＦＣＤ症状活检至癌变为２～１０年；从Ⅱ级以上不典型增生到临床癌变需２～７年；癌变率为３．１％。ＦＣＤ患者存在性激素分泌调控失常，血浆雌激素和催乳素含量增加，导致上皮细胞增生。乳腺一般性增生细胞的ＤＮＡ含量和超微结构与正常乳腺上皮细胞相似；无肿瘤相关抗原及异常基因产物表达。而发生在一般性增生基础上的不典型增生则呈现细胞基因物质ＤＮＡ含量增加，部分为超４Ｃ的多倍体细胞；同时出现细胞膜和细胞核超微结构异常；雌激素受体含量增加，对性激素的依赖性和敏感性增强；部分不典型增生细胞出现胚胎性肿瘤相关抗原和异常基因产物表达。随不典型增生程度加重至乳腺癌，上述诸因素的变化趋势具有明显规律性。提示ＦＣＤ上皮细胞从一般性增生经不典型增生至乳腺癌为细胞生物学连续逐渐变化的过程。部分不典型增生细胞中具有癌倾向的细胞生物学行为异常和表型变化与乳腺癌发生密切相关。细胞核ＤＮＡ含量等异常变化及程度可作为乳腺癌前病变发展程度的客观标志