全文获取类型
收费全文 | 637篇 |
免费 | 21篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 112篇 |
妇产科学 | 8篇 |
基础医学 | 72篇 |
口腔科学 | 11篇 |
临床医学 | 53篇 |
内科学 | 150篇 |
皮肤病学 | 4篇 |
神经病学 | 11篇 |
特种医学 | 133篇 |
外科学 | 29篇 |
综合类 | 11篇 |
预防医学 | 28篇 |
眼科学 | 3篇 |
药学 | 29篇 |
肿瘤学 | 23篇 |
出版年
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 4篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 3篇 |
2014年 | 13篇 |
2013年 | 16篇 |
2012年 | 18篇 |
2011年 | 18篇 |
2010年 | 15篇 |
2009年 | 18篇 |
2008年 | 19篇 |
2007年 | 26篇 |
2006年 | 23篇 |
2005年 | 23篇 |
2004年 | 23篇 |
2003年 | 10篇 |
2002年 | 13篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 12篇 |
1998年 | 34篇 |
1997年 | 19篇 |
1996年 | 24篇 |
1995年 | 18篇 |
1994年 | 23篇 |
1993年 | 13篇 |
1992年 | 11篇 |
1991年 | 14篇 |
1990年 | 15篇 |
1989年 | 24篇 |
1988年 | 37篇 |
1987年 | 15篇 |
1986年 | 21篇 |
1985年 | 23篇 |
1984年 | 13篇 |
1983年 | 10篇 |
1982年 | 10篇 |
1981年 | 6篇 |
1980年 | 13篇 |
1979年 | 6篇 |
1978年 | 2篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1973年 | 2篇 |
1947年 | 1篇 |
1898年 | 1篇 |
排序方式: 共有678条查询结果,搜索用时 40 毫秒
51.
52.
53.
54.
55.
56.
57.
In vitro treatment with interleukin-2 normalizes type-1 cytokine production by lymphocytes from elderly 总被引:4,自引:0,他引:4
Lio D Balistreri CR Candore G D'Anna C Di Lorenzo G Gervasi F Listì F Scola L Caruso C 《Immunopharmacology and immunotoxicology》2000,22(2):195-203
The term immunosenescence is taken to mean the deterioration of immune function seen in elderly, which is manifested in increased susceptibility to infectious diseases, neoplasias, and autoimmune diseases. It is only recently that we have begun to understand the cellular and molecular changes involved. Of special interest in this regard are observations of a decline in synthesis of Type-1 cytokines which predisposes to diminished cell mediated immunity. We have evaluated the production of type 1 cytokines in old and young donors either in presence or in absence of recombinant interleukin-2 (rIL-2). Lymphocytes were stimulated with plastic bound anti-CD3 and after 48 h the supernatants were harvested and stored at-70 °C until assay. Type 1 cytokine, i.e.IL-12 and interferon-γ (IFN-γ) production by anti-CD3 stimulated lymphocytes from old subjects was significantly reduced when compared to that from young ones. This impaired production was reversed by adding rIL-2 in the culture medium. In previous studies on aged subjects, we have been able to demonstrate that in vitro treatment with rIL-2 completely restores proliferative responses and partially rescues the increased apoptosis of T cell cultures. Present and previous results suggest that rIL-2 completely restores Type 1 responses by overcoming the well known costimulation deficit of aged lymphocytes. 相似文献
58.
40年前创立的青少年糖尿病研究基金会((JDRF)是一个致力于通过支持研究来探寻1型糖尿病(TIDM)及其并发症治疗方法的组织.20世纪70年代有学者提出,TIDM和2型糖尿病(T2DM)的发病机制有根本的不同,T1DM与主要组织相容性复合体的人白细胞抗原(HLA)有独特相关性,有胰岛细胞自身抗体. 相似文献
59.
Strangulation in child abuse: CT diagnosis 总被引:2,自引:0,他引:2
The central nervous system is commonly affected in child abuse. Between April 1985 and July 1986 three infants were identified in whom the primary mode of injury had been strangulation. In each case computed tomography (CT) demonstrated a large cerebral infarction confined to vascular territories associated with small subdural hematomas. There was no history or visible evidence of significant head trauma. Autopsy of one infant confirmed the presence of a hemispheric infarct, thin subdural hematoma, and an area of subintimal hemorrhage in the carotid artery ipsilateral to the infarct. The remaining two patients survived with residual hemiparesis. CT findings of a large cerebral infarction with an associated subdural hematoma in an infant without a history of a significant trauma should suggest the possibility of child abuse and may be the primary manifestation of abuse in some patients. 相似文献
60.
Intracranial abnormalities in infants treated with extracorporeal membrane oxygenation: imaging with US and CT 总被引:1,自引:0,他引:1
Findings at neuroimaging in 100 consecutive infants treated with extracorporeal membrane oxygenation (ECMO) are presented. Imaging in these infants consisted of pretreatment cranial ultrasonography (US), daily US studies while on ECMO, and follow-up cranial computed tomography (CT) after treatment. There were findings of abnormalities in 43 patients. Thirty had intracranial bleeding, often of unusual extent and distribution. Thirteen additional infants had nonhemorrhagic abnormalities alone. Bleeding considered to be major was seen in 12% of infants. Large parenchymal hemorrhages and infarcts, cerebellar hemorrhages, and diffuse edema were the most significant abnormalities, with a 50% mortality (eight of 16 patients). No lateralization was noted with respect to distribution of bleeding sites or areas of nonhemorrhagic abnormalities. US was a sensitive but imperfect screening tool for intracranial abnormalities. Abnormalities missed with US included peripheral and small parenchymal lesions, subarachnoid hemorrhage, cerebral atrophy, and sagittal sinus thrombosis. 相似文献