Post-parotitis myocarditis: case report

In November, 1993,M.G., a 6 year and 11 month-old girl, was admitted at Hospital Infantil Joana de Gusm?o--Florianópolis, SC, Brazil--with post-parotitis myocarditis and congestive heart failure. Three days after admission it was evidenced, on an echocardiogram, a thrombus in the left ventricle apex which, despite of correct treatment, embolized to iliac and small mesenteric arteries. Epidemic parotitis (mumps) is very common, being endemic around the world. Complications are rare and myocarditis, one of them, is more common than diagnosed because of its poor and benign manifestations, generally transient abnormalities of cardiac rhythm and conduction. This case was astonishing because of its rare subsequent event, that is, the formation of a ventricular mural thrombus during an acute myocarditis.     

New eudesmane sesquiterpene and other constituents from Artemisia mongolica

The aerial parts of Artemisia mongolica afforded the eudesmane derivative ludovicin B, two coumarins, umbelliferone and esculetin, two methoxylated flavones, eupatilin and pectolinarigenin, as well as a new eudesmane sesquiterpene, 6alpha,8alpha-dihydroxyisocostic acid methyl ester. Structures were elucidated by highfield 1D and 2D NMR techniques.     

空蝶鞍综合征20例的临床和MRI分析

分析２０例空蝶鞍综合征（ＥＳＳ）的ＭＲＩ表现和其中１６例的内分泌改变。结果１６例ＥＳＳ均有内分泌功能异常。ＭＲＩ表现有蝶鞍充满长Ｔ＿１和长Ｔ＿２的脑脊液;垂体受压至鞍底,冠状位呈“锚”状,矢状位呈“新月”状;垂体柄延长。结果表明ＥＳＳ常具有内分泌功能紊乱,ＭＲＩ对ＥＳＳ具有特征性诊断意义。     

国产长效皮下埋植剂和Norplant的药物体外释放比较

本文研究了国产18-甲基炔诺酮硅橡胶长效皮下埋植剂的药物体外释放,并与进口Norplant进行了比较。释放试验采用水平振荡法,实验条件符合“漏槽”状态的要求。用紫外分光光度法在240 nm波长处测定18-甲基炔诺酮每天的体外释放量。二年多体外释放试验的实验结果表明:国产埋植剂的药物体外释放无爆破效应,释药速度稳定,为零级速度。平均每天释放量为85μg。体外释放的重现性好。进口Norplant则有明显的爆破效应,经10天释放,才趋于稳定,平均每天释药量为68μg。     

静脉溶栓治疗高龄急性心肌梗死患者的临床探讨

目的　探讨静脉溶栓疗法对高龄急性心肌梗死患者的疗效及安全性。 方法　将 82例高龄急性心肌梗死患者随机分为溶栓组和常规治疗组。溶栓组 40例 ,采用尿激酶静脉溶栓加皮下注射低分子肝素钙。常规治疗组 42例 ,除不用尿激酶及低分子肝素钙外 ,其余治疗均与溶栓组相同。 结果　 血管再通率溶栓组为6 5 %(2 6 / 40 ) ,常规治疗组为 14.3%(6 / 42 ) ,两组血管再通率比较差异具有显著性 (P <0 .0 5 )。溶栓组未见严重出血等并发症。住院 4周内病死率为 5 %。而常规治疗组病死率为 2 3.8%(10 / 42 ) ,两组比较具有显著差异性(P <0 .0 5 )。 结论　 尿激酶静脉溶栓治疗高龄急性心肌梗死可以提高冠脉再通率 ,降低死亡率和改善预后 ,是可行性治疗措施。     

α_1受体对不同状态心肌细胞的作用

目的　通过激活和阻断不同状态心肌的α1 受体 ,探讨α1 受体的活化状态与不同状态心肌的关系。方法　采用Langedorff灌流技术复制动物模型。第 1个实验检验不同浓度的α1 受体激动剂 phenylephrine和阻断剂 prazosin(0 0 1、0 1、1、1 0、1 0 0 μmol·L- 1 )在缺血前 1 0min、缺血期和再灌注时的效应。第 2个实验研究 phenylephrine和 prazosin的时间依赖性。每组实验的末期 ,测量磷酸肌酸激酶、细胞凋亡和坏死情况。结果　 0 1、1 μmol·L- 1 的 phenylephrine可发挥最大效益 ,但prazosin浓度超过 1 0 μmol·L- 1 可产生有害作用。缺血前激活、缺血期间阻断α1 受体可保护心肌。再灌注时激活α1 受体效应不明确 ,但阻断α1 受体有害。结论　激动或阻断α1 受体所产生的效应与心肌的状态有关     

注射用阿莫西林钠克拉维酸钾细菌内毒素检查

目的建立注射用阿莫西林钠克拉维酸钾细菌内毒素检查方法.方法按中国药典2000年版附录细菌内毒素检查法要求进行试验.结果注射用阿莫西林钠克拉维酸的浓度为2.5mg/ml时不干扰鲎试剂与细菌内毒素的凝胶反应.结论细菌内毒素检查法适用于检测注射用阿莫西林钠克拉维酸钾中的内毒素.     

非小细胞肺癌微切割组织中3p杂合性丢失的研究

目的:探讨微切割非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中3p14.2和3p25等位基因的杂合性丢失(loss of heterozygosity,LOH)与NSCLC发生发展之间的相关性.方法:采用微切割技术和聚合酶链反应(PCR)结合二核苷酸(CA)n重复序列多态性方法,分析44例NSCLC石蜡切片中癌组织和非癌组织中3p14.2和3p25位点的杂合性丢失(LOH).结果:在44例NSCLC中29例组织标本检测3p14.2位点的LOH,其丢失率为65.5%(19/29),而另外15例患者中3p25的LOH的丢失率为40.0%(6/15).微切割的非癌组织均未见有3p的丢失,癌组织的3p LOH频率与肺癌组织学分类及TNM分期均无明显关系(P＞0.05).结论:NSCLC癌组织中普遍出现3p14.2及3p25杂合性丢失现象,从而提示该两处可能存在一个或多个与人体肺细胞癌变相关的抑癌基因.     

Effects of the glucoprotein component of musk on functions of rat polymorphonuclear leukocytes activated by LTB4 in vitro]

To investigate the effects of musk-1, a glucoprotein component isolated from the water extract of musk, on some functions of rat polymorphonuclear leukocytes activated by LTB4, an in vitro incubation system with rat polymorphonuclear leukocytes was used. The superoxide anion production was determined by cytochrome C reduction, and the beta-glucuronidase and lysozyme release was quantitated by enzyme reactions in which phenolphthaleinglucuronic acid and micrococcus lysodeikticus were used as the substrates. In comparison with the control, musk-1 at final concentrations of 1 microgram/ml-100 micrograms/ml can increase the superoxide anion production by 28.7%-202.1% and decrease the beta-glucuronidase and lysozyme release by 3%-46% and 6%-32% respectively in rat polymorphonuclear leukocytes. It is concluded that musk-1 can significantly affect the functions of rat polymorphonuclear leukocytes activated by LTB4. One of the mechanisms of this anti-inflammatory action of musk may consist in the inhibition of lysosomal enzyme release.     

LOSS OF HETEROZYGOSITY ON CHROMOSOME 13 IN SQUAMOUS CELL CARCINOMAS OF THE LARYNX

ＬＯＳＳＯＦＨＥＴＥＲＯＺＹＧＯＳＩＴＹＯＮＣＨＲＯＭＯＳＯＭＥ１３ＩＮＳＱＵＡＭＯＵＳＣＥＬＬＣＡＲＣＩＮＯＭＡＳＯＦＴＨＥＬＡＲＹＮＸＢａｉＳｕｊｕａｎ白素娟ＺｈａｎｇＸｕｅ张学ＷａｎｇＪｕｎ王筠ＳｕｎＫａｉｌａｉ孙开来ＦｅｉＳｈｅｎｇｚｈｏｎ...