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161.
162.
Effects of remifentanil and alfentanil on the cardiovascular responses to induction of anaesthesia and tracheal intubation in the elderly 总被引:8,自引:3,他引:5
Habib AS Parker JL Maguire AM Rowbotham DJ Thompson JP 《British journal of anaesthesia》2002,88(3):430-433
Background. We compared the effects of remifentanil and alfentanilon arterial pressure and heart rate at induction of anaesthesiaand tracheal intubation in 40 ASA IIII patients agedgreater than 65 yr, in a randomized double-blind study. Methods. Patients received either remifentanil 0.5 µgkg1 over 30 s, followed by an infusion of 0.1 µgkg min1 (group R) or alfentanil 10 µg kg1over 30 s, followed by an infusion of saline (group A). Anaesthesiawas then induced with propofol, rocuronium, and 1% isofluranewith 66% nitrous oxide in oxygen. Results. Systolic arterial pressure (SAP) and mean arterialpressure (MAP) decreased after the induction of anaesthesia(P<0.05) and increased for 3 min after intubation in bothgroups (P<0.05), but remained below baseline values throughout.Heart rate remained stable after induction of anaesthesia butincreased significantly from baseline after intubation for 1and 4 min in groups R and A, respectively (P<0.05). Therewere no significant between-group differences in SAP, MAP, andheart rate. Diastolic pressure was significantly higher in groupA than group R at 4 and 5 min after intubation (P<0.05).Hypotension (SAP <100 mm Hg) occurred in four patients ingroup R and three patients in group A. Conclusions. Remifentanil and alfentanil similarly attenuatethe pressor response to laryngoscopy and intubation, but theincidence of hypotension confirms that both drugs should beused with caution in elderly patients. Br J Anaesth 2002; 88: 4303 相似文献
163.
Ambrosi P Aillaud MF Habib G Kreitmann B Métras D Luccioni R Bouvenot G Juhan-Vague I 《Thrombosis and haemostasis》2000,83(1):46-48
We conducted a randomized, placebo controlled, double-blind, cross-over study, to assess the effects of a 4-week fluvastatin therapy on plasma markers of endothelial activation or injury in 20 transplanted heart recipients. The levels of thrombomodulin and von Willebrand factor antigen were higher at baseline in cardiac transplant recipients than in age and sex-matched healthy controls. Plasma total cholesterol showed a 21% reduction on fluvastatin therapy (p = 0.0001). Fluvastatin treatment had no significant effect on creatininemia, plasma cyclosporine, PAI-1 antigen, PAI-1 activity, tPA antigen, and Von Willebrand factor. However, fluvastatin produced a significant decrease of plasma thrombomodulin (66.7 ng/ml on placebo versus 58.8 ng/ml on fluvastatin, p <0.001), suggesting a rapid improvement of endothelial injury in these patients. 相似文献
164.
165.
Central scotoma associated with intraocular silicone oil tamponade develops before oil removal 总被引:2,自引:0,他引:2
E. N. Herbert M. Habib D. Steel T. H. Williamson 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(2):248-252
Background Unexplained sudden visual loss after removal of silicone oil from the eye has recently been described. We report the occurrence
and features of unexplained central scotoma developing with silicone oil in situ in the vitreous cavity.
Methods A retrospective case series of five patients (from two centres) who reported a central scotoma commencing during silicone
oil tamponade was studied. All patients had vitrectomy for macula-on retinal detachment, with ultra-purified silicone oil
tamponade (four out of five had giant retinal tear). Investigations included visual acuity, intraocular pressure, optical
coherence tomography, fluorescein angiography, visual fields and electrophysiology.
Results All patients reported a central scotoma that appeared during oil tamponade. Visual acuity fell by a mean of 0.93 LogMAR units
after onset of the scotoma. After cataract extraction and oil removal, vision remained reduced by a mean of 0.8 units. The
mean duration of oil in the eye was 2.7 months when the scotoma was noted by the patient. Investigations were performed after
removal of oil. Fluorescein angiography (FFA) was performed in two cases and optical coherence tomography (OCT) in five patients.
No abnormality was demonstrated. Electrophysiology was performed in five patients with pattern electroretinography suggestive
of macular dysfunction in four patients.
Conclusion This is the first case series describing central scotoma associated with silicone oil in situ. Electrophysiology indicated
macular dysfunction in most cases. We suggest that early removal of oil in cases with good visual potential should be considered
to avoid this sight-threatening complication.
Presented in part at Britain and Eire Association of Vitreo-Retinal Surgeons, November 2003. 相似文献
166.
Kamal-Eldin A. Abou-Elhamd Tito Naeem Habib Abd-Elmateen Moussa Badawy S. Badawy 《European archives of oto-rhino-laryngology》2008,265(2):217-222
Our research is an additional genetic study to uncover the molecular mechanisms involved in head and neck squamous cell carcinoma
(HNSCC) pathogenesis by studying loss of heterozygosity (LOH) and microsatellite instability (MSI) in both premalignant and
malignant patients and to highlight the genotype of HNSCC in Upper Egypt. Patients with HNSCC from various parts of the world
may have unique genotypes and this is the first genetic study of HNSCC in Sohag 500 KM to the south of Cairo. We performed
a prospective study of 41 patients with precancerous and 79 patients with cancerous laryngeal, esophageal, nasopharyngeal,
nasal and oral lesions, and 50 controls (The control patients were cases admitted for ear surgery or simple nasal surgery,
from whom we took biopsy from mucosal lining of nasopharynx). The present study included 170 individuals who were admitted
to the Ear, Nose and Throat department, Sohag University Hospital, Sohag, in Egypt in the period between April 2001 and March
2003. Samples which were taken by punch biopsy were frozen and stored at −80°C and were subjected to histopathological examination.
We investigated LOH and MSI by using six microsatellite markers located at chromosomes 3, 5, 9, and 17. The markers used were
D3S1286, D9S171, D9S753, D17S654, D17S695, and CFS1-R. LOH was in all premalignant and malignant lesions at 5q33.3-q34 and
13% of Controls. LOH at 17p21 was absent in all premalignant lesions and was found in 53% of malignant lesions and 12.4% of
Controls. In premalignant lesions, LOH was at 3pter-3p24.2 (73% of cases), at 9p21 (46%), at 9q21.1-22.3 (37%), and at 17p13
(37%). These percents increased in malignant lesions to 87, 80, 67, and 63%, respectively. They were 14, 19.4, 17, and 19%
in controls. Examination of LOH could improve diagnosis, adds additional confidence, in HNSCC by DNA extraction from suspicious
lesions in high-risk groups (smokers and alcoholics) and LOH at 3p/9p seems to be of particular value for early detection
and definition of progression risk. If there are high percent of LOH at these chromosomes, active intervention should be done
(chemoprevention and regular follow up head and neck examination for very early detection and management). 相似文献
167.
Glutathione synthesis is essential for mouse development but not for cell growth in culture 下载免费PDF全文
Shi ZZ Osei-Frimpong J Kala G Kala SV Barrios RJ Habib GM Lukin DJ Danney CM Matzuk MM Lieberman MW 《Proceedings of the National Academy of Sciences of the United States of America》2000,97(10):5101-5106
Glutathione (GSH) is a major source of reducing equivalents in mammalian cells. To examine the role of GSH synthesis in development and cell growth, we generated mice deficient in GSH by a targeted disruption of the heavy subunit of gamma-glutamylcysteine synthetase (gammaGCS-HS(tm1)), an essential enzyme in GSH synthesis. Embryos homozygous for gammaGCS-HS(tm1) fail to gastrulate, do not form mesoderm, develop distal apoptosis, and die before day 8.5. Lethality results from apoptotic cell death rather than reduced cell proliferation. We also isolated cell lines from homozygous mutant blastocysts in medium containing GSH. These cells also grow indefinitely in GSH-free medium supplemented with N-acetylcysteine and have undetectable levels of GSH; further, they show no changes in mitochondrial morphology as judged by electron microscopy. These data demonstrate that GSH is required for mammalian development but dispensable in cell culture and that the functions of GSH, not GSH itself, are essential for cell growth. 相似文献
168.
S. F. Ding J. D. Delhanty L. Bowles J. S. Dooley C. B. Wood N. A. Habib 《British journal of cancer》1993,67(2):244-246
As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambda MS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses. 相似文献
169.
Granel B Serratrice J Swiader L Horshowski N Blaise D Vey N Metras D Habib G Disdier P Weiller PJ 《Cancer》2000,89(10):2144
170.