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131.
Hechmi Ben Hamouda Hanen Mnasri Sobhi Ghanmi Habib Soua Gazi Sakli Mohamed Dogui Mohamed Tahar Sfar 《Pediatria polska》2014
West syndrome is the most frequent cause of epilepsy in Down syndrome. West syndrome is often associated with poor long-term prognosis in most of children. We report a girl with West syndrome associated with Down syndrome which occurred at 8 months of age for repetitive flexor spasms and electroencephalography (EEG) showed hypsarrhythmia. She had Down syndrome facies, microcephaly, psychomotor development delay and axial hypotonia. Computed tomography of the brain was normal. Her karyotype was 47, XX, +21. Phenobarbital therapy was immediately effective with good clinical control of seizures, while the EEG monitored after one month was unchanged. At 2 years of age, the patient had hypertonic status epilepticus following a lung infection. The EEG showed a persistence of hypsarrhythmia. Sodium valproate and hydrocortisone therapy was effective with good seizure control but her psychomotor development was severely impaired. After a follow-up of 7 years, the patient presents growth retardation, microcephaly, severe psychomotor development delay, generalized hypotonia and tetraparesis. Knowledge of West syndrome in Down syndrome allows the early detection and prompt management of this neurological complication in order to optimize psychomotor development and improve the quality of life of these children. 相似文献
132.
133.
Thibaud Damy Vronique Benedyga Tho Pezel Emmanuelle Berthelot Jacques Gauthier Gilbert Habib Marie-Christine Iliou Jean-Franois Aupetit Guillaume Baudry Pascal De Groote Damien Logeart Laure Chaufourier Vlad Ciobotaru Franoise Pousset Florence Beauvais Fabrice Bauer Florian Zores Olivier Lairez Kevin Richard Luc Hittinger Emmanuel Teiger Charles Taieb Etienne Audureau 《Nutrients》2022,14(2)
(1) Background: There is much debate about the use of salt-restricted diet for managing heart failure (HF). Dietary guidelines are inconsistent and lack evidence. (2) Method: The OFICSel observatory collected data about adults hospitalised for HF. The data, collected using study-specific surveys, were used to describe HF management, including diets, from the cardiologists’ and patients’ perspectives. Cardiologists provided the patients’ clinical, biological, echocardiography, and treatment data, while the patients provided dietary, medical history, sociodemographic, morphometric, quality of life, and burden data (burden scale in restricted diets (BIRD) questionnaire). The differences between the diet recommended by the cardiologist, understood by the patient, and the estimated salt intake (by the patient) and diet burden were assessed. (3) Results: Between March and June 2017, 300 cardiologists enrolled 2822 patients. Most patients (90%) were recommended diets with <6 g of salt/day. Mean daily salt consumption was 4.7 g (standard deviation (SD): 2.4). Only 33% of patients complied with their recommended diet, 34% over-complied, and 19% under-complied (14% unknown). Dietary restrictions in HF patients were associated with increased burden (mean BIRD score of 8.1/48 [SD: 8.8]). (4) Conclusion: Healthcare professionals do not always follow dietary recommendations, and their patients do not always understand and comply with diets recommended. Restrictive diets in HF patients are associated with increased burden. An evidence-based approach to developing and recommending HF-specific diets is required. 相似文献
134.
Imen Chaabani Jed Bouguila Rym Kammoun Raja Chebbi Badreddine Sriha Habib Khochteli Touhami Ben Alaya 《Clinical Case Reports》2022,10(1)
We present two cases of AOT, the first case concerns a 23‐year‐old patient with an AOT located in the maxilla and the second case involves a 37‐year‐old patient presenting an AOT with mandibular localization. 相似文献
135.
Mhd Baraa Habib Bashar Tannos Mohamed Abdelrazek Mohamed A. Yassin 《Clinical Case Reports》2022,10(2)
Acute lymphoblastic leukemia is one of the rare malignancies in adult. We report a 29‐year‐old man presented with progressive limping followed a chronic back pain. Imaging showed reduced vertebral body height and diffuse lytic skeletal infiltration. Bone marrow aspiration confirmed B‐acute lymphoblastic leukemia/lymphoma, and the patient was treated with chemotherapy. 相似文献
136.
Awais Khalid Pervaiz Ahmad Abdulhameed Khan Mayeen Uddin Khandaker Imen Kebaili Md Mottahir Alam Israf Ud Din Saleh Muhammad Zohaib Razzaq Ibad Ur Rehman Habib Ahmad Abbasi Danish Hayat 《RSC advances》2022,12(11):6592
Boron nitride (BN) nanomaterials are rapidly being investigated for potential applications in biomedical sciences due to their exceptional physico-chemical characteristics. However, their safe use demands a thorough understanding of their possible environmental and toxicological effects. The cytotoxicity of boron nitride nanotubes (BNNTs) was explored to see if they could be used in living cell imaging. It was observed that the cytotoxicity of BNNTs is higher in cancer cells (65 and 80%) than in normal cell lines (40 and 60%) for 24 h and 48 h respectively. The influence of multiple experimental parameters such as pH, time, amount of catalyst, and initial dye concentration on percentage degradation efficiency was also examined for both catalyst and dye. The degradation effectiveness decreases (92 to 25%) as the original concentration of dye increases (5–50 ppm) due to a decrease in the availability of adsorption sites. Similarly, the degradation efficiency improves up to 90% as the concentration of catalyst increases (0.01–0.05 g) due to an increase in the adsorption sites. The influence of pH was also investigated, the highest degradation efficiency for MO dye was observed at pH 4. Our results show that lower concentrations of BNNTs can be employed in biomedical applications. Dye degradation properties of BNNTs suggest that it can be a potential candidate as a wastewater and air treatment material.Photocatalytic degradation studies of methyl orange using BNNTs. 相似文献
137.
Selective oxidation reactions represent a challenging task for conventional organic chemistry. Whole-cell biocatalysis provides a very convenient, easy to apply method to carry out different selective oxidation reactions including chemo-, regio-, and enantio–selective reactions. Streptomyces species are important biocatalysts as they can catalyze these selective reactions very efficiently owing to the wide diversity of enzymes and enzymatic cascades in their cell niche. In this review, we present and analyze most of the examples reported to date of oxidative reactions catalyzed by Streptomyces species as whole-cell biocatalysts. We discuss 33 different Streptomyces species and strains and the role they play in different oxidative reactions over the past five decades. The oxidative reactions have been classified into seven categories that include: hydroxylation of steroids/non-steroids, asymmetric sulfoxidations, oxidation of aldehydes, multi-step oxidations, oxidative cleavage, and N-oxidations. The role played by Streptomyces species as recombinant hosts catalyzing bio-oxidations has also been highlighted.Types of oxidation reactions catalyzed by whole cells of different Streptomyces species. 相似文献
138.
139.
Joanne Bero Habib Ganfon Marie-Caroline Jonville Michel Frédérich Fernand Gbaguidi Patrick DeMol Mansourou Moudachirou Joëlle Quetin-Leclercq 《Journal of ethnopharmacology》2009
Aim of the study
The aim of the study was to evaluate the in vitro antiplasmodial activity of crude extracts of 12 plant species traditionally used in Benin for the treatment of malaria in order to validate their use.Materials and methods
For each species, dichloromethane, methanol and total aqueous extracts were tested. The antiplasmodial activity of extracts was evaluated using the measurement of the plasmodial lactate dehydrogenase activity on chloroquine-sensitive (3D7) and resistant (W2) strains of Plasmodium falciparum. The selectivity of the different extracts was evaluated using the MTT test on J774 macrophage-like murine cells and WI38 human normal fibroblasts.Results
The best growth inhibition of both strains of Plasmodium falciparum was observed with the dichloromethane extracts of Acanthospermum hispidum DC. (Asteraceae) (IC50 = 7.5 μg/ml on 3D7 and 4.8 μg/ml on W2), Keetia leucantha (K. Krause) Bridson (syn. Plectronia leucantha Krause) (Rubiaceae) leaves and twigs (IC50 = 13.8 and 11.3 μg/ml on 3D7 and IC50 = 26.5 and 15.8 μg/ml on W2, respectively), Carpolobia lutea G.Don. (Polygalaceae) (IC50 = 19.4 μg/ml on 3D7 and 8.1 μg/ml on W2) and Strychnos spinosa Lam. (Loganiaceae) leaves (IC50 = 15.6 μg/ml on 3D7 and 8.9 μg/ml on W2). All these extracts had a low cytotoxicity.Conclusion
Our study gives some justifications for the traditional uses of some investigated plants. 相似文献140.
Hwaida?Hannoush Khuzama?Shaar Samir?Alam Antoine?Nasrallah Jaber?Sawaya Habib?A.?DakikEmail author 《Journal of nuclear cardiology》2003,10(2):148-153
BACKGROUND: Most of the published data on myocardial perfusion imaging (MPI) come from large tertiary-referral medical centers with extensive experience in cardiac imaging as well as a large volume of procedures. Whether the results of MPI remain as reliable in new nuclear cardiology laboratories with smaller volumes of procedures is unknown. The purpose of this study was to analyze the referral patterns, predictive accuracy, and impact of MPI on clinical practice in a newly opened nuclear cardiology laboratory. METHODS AND RESULTS: We performed a prospective study on all patients referred for MPI at our nuclear cardiology laboratory during its first year of operation. Patients were followed up for 3 months after the MPI study to determine whether they underwent coronary angiography. The study population consisted of 334 patients. Their mean age was 56 +/- 10 years, and 80% were men. Of the patients, 30% were asymptomatic, 29% had angina, and only 6% had recent acute myocardial infarction or unstable angina. Fifty-one patients (fifteen percent) were subsequently referred for coronary angiography. The positive and negative predictive values of MPI were 91% and 86%, respectively. The presence of reversible perfusion defects (P =.02) and the presence of multiple perfusion defects (P =.01) on MPI were the most important determinants of subsequent referral to coronary angiography. CONCLUSIONS: MPI stress testing retains its high diagnostic accuracy in a new nuclear cardiology laboratory with a relatively small volume of procedures. Furthermore, MPI findings in this population had a strong impact on the clinical practice of the referring physicians in terms of subsequent referral to coronary angiography. 相似文献