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51.
HU Jie胡杰 JIANG Cheng-chuan江澄川 Ho-Keung Ng吴浩强 Jesse CS Pang 彭颂先 Carol YK Tong唐婉君 CHEN Shang-qun 陈商群 《中国癌症研究》2002,14(3):183-186
Glioblastoma multiforme (GBM), the most malignant type of glioma, is the most common primary brainneoplasm. Although comprehensive therapeutic measures are applied, the prognosis of GBM remains dismal with a median post-treatment survival of less than one year.Modern molecular genetics has demonstrated thatabnormal alterations of tumor suppressor genes (TSGs) and oncogenes are the major mechanisms responsible for the initiation and progression of this malignant tumor.Identifying of related… 相似文献
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B. J. WARD A. S. BREATHNACH E. J. ROBINS Y. BHASIN L. ETHRIDGE S. PASSI M. NAZZARO-PORRO 《The British journal of dermatology》1984,111(1):29-36
Lentigo maligna and malignant melanoma can be treated by dicarboxylic acids (C9 and C12), which are competitive inhibitors of tyrosinase. We therefore studied the intracellular location and possible sites of action of dodecanedioic acid (C12) in murine melanoma cells, using EM autoradiography and biochemical analysis of lipid extracts by HPLC. Significant levels of radioactivity were found in the mitochondria and in the nuclei but not in association with membranes of rough endoplasmic reticulum, Golgi-associated endoplasmic reticulum, or Golgi apparatus, and not in coated vesicles or melanosomes. Biochemical analysis revealed that the diacid underwent beta-oxidation, which occurs only in mitochondria. The results suggest that the toxicity of dicarboxylic acids in melanoma cells is not related to anti-tyrosinase activity but may be due to interference with oxidoreductase enzymes in the mitochondria and possibly to inhibition of DNA synthesis in the nucleus. 相似文献
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Anatomy and pathology of the kidney by gray scale ultrasound 总被引:1,自引:0,他引:1
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Gina Kearney MSN RN CS AHN-BC JeMe Cioppa-Mosca PT MBA Margaret G. E. Peterson Ph.D C. Ronald MacKenzie MD 《HSS journal》2007,3(2):198-201
In an outpatient rehabilitation setting, both patients’ use and therapists’ knowledge of complementary and alternative medicine
(CAM) varies widely. Based on this observation and a recognition of CAM as an emerging practice area for rehabilitation professionals,
it was felt that a thorough and consistent approach to the education and orientation of physical therapists to the world of
CAM and integrative care was needed. This special interest paper will describe one center’s approach, development, and use
of a unique and comprehensive training manual designed to provide both a structured and standardized approach for educating
physical therapists about CAM and related therapeutic modalities. This innovative teaching tool allows for multiple methods
of content delivery within a multidisciplinary format and can be used for those who practice currently or desire to practice
in an integrative care environment. 相似文献
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