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Impressive tissue regeneration of severe oral mucositis post stem cell transplantation using cord blood platelet gel 下载免费PDF全文
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Barosi G Merlini G Billio A Boccadoro M Corradini P Marchetti M Massaia M Tosi P Palumbo A Cavo M Tura S 《Annals of hematology》2012,91(6):875-888
In this project, we produced drug-specific recommendations targeting the use of new agents for multiple myeloma (MM). We used the GRADE (Grades of Recommendation, Assessment, Development, and Evaluation) system which separates the judgments on quality of evidence from the judgment about strength of recommendations. We recommended thalidomide and bortezomib in MM patients candidates to autologous stem cell transplantation (ASCT) (weak positive). We did not recommend novel agents as maintenance therapy after ASCT (weak negative). In patients not candidate to ASCT, thalidomide or bortezomib (strong positive) associated with melphalan and prednisone were recommended. In these patients, no specific course of action could be recommended as for maintenance therapy. In patients who are refractory or relapsing after first-line therapy, we recommended bortezomib and pegylated liposomal doxorubicin, or lenalidomide and dexamethasone combinations (weak positive). 相似文献
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Francesca Schieppati Laura Russo Marina Marchetti Luca Barcella Maurizio Cefis Patricia Gomez-Rosas Gloria Caldara Monica Carpenedo Mariella D'Adda Alessandro Rambaldi Chiara Savignano Atto Billio Massimiliano Bruno Franco Vincenzo Toschi Anna Falanga 《American journal of hematology》2020,95(8):953-959
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening immune-mediated thrombotic microangiopathy. Daily therapeutic plasma exchange (TPE) and the optimized use of rituximab have strikingly improved the outcome of this disease, however the rate of disease recurrence remains high. Specific predictors of relapse in patients in remission can be relevant for an optimal patient management. In this study, we aimed to identify predictive variables of disease relapse in a multicenter cohort of 74 out of 153 iTTP patients. They were tested at different time points during remission for the levels of ADAMTS-13 activity and autoantibody, and did not receive pre-emptive treatment for ADAMTS-13 activity deficiency during remission. The results showed that the association of ADAMTS13 activity ≤20% with a high anti-ADAMTS-13 titer at remission, and the time to response to first line treatment ≥13 days, were independent predictive factors of disease relapse. In addition, the use of rituximab in patients with exacerbation or refractoriness to TPE was significantly associated with reduced relapse rate. By Cox regression analysis, patients with ADAMTS-13 activity ≤20% plus anti-ADAMTS13 antibody titer ≥15 U/mL at remission had an increased risk of relapse (HR 1.98, CI 95% 1.087-3.614; P < .02). These findings may help to outline more personalized therapeutic strategies in order to provide faster and sustained responses to first-line iTTP treatment and prevent relapses in these patients. 相似文献
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SIE, SIES, GITMO updated clinical recommendations for the management of chronic lymphocytic leukemia
Mauro FR Bandini G Barosi G Billio A Brugiatelli M Cuneo A Lauria F Liso V Marchetti M Meloni G Montillo M Zinzani P Tura S;Italian Society of Hematology;Società Italiana di Ematologia Sperimentale;Gruppo Italiano Trapianto di Midollo Osseo 《Leukemia research》2012,36(4):459-466
By using GRADE system we updated the guidelines for management of CLL issued in 2006 from SIE, SIES and GITMO group. We recommended fludarabine, cyclophosphamide, rituximab (FCR) in younger and selected older patients with a good fitness status, no unfavourable genetics (deletion 17p and/or p53 mutations), and a less toxic treatment in nonfit and elderly patients. In patients without unfavourable genetics, relapsed after 24 months the same initial treatment including rituximab can be considered. In patients with unfavourable genetics, refractory or relapsed within 24 months from a prior fludarabine-based treatment, allogeneic SCT or experimental treatments should be given. 相似文献
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Giampaolo A Abbonizio F Puopolo M Arcieri R Mannucci PM;Italian Association of Haemophilia Centres Hassan HJ Accorsi A Ettorre PC Schiavoni M Palareti G Rodorigo G Valdré L Amaddii G Billio A Notarangelo L Iannacaro P Muleo P Biasioli C Rossi V Alatri A Testa S Vincenzi D Scapoli G Morfini M Molinari AC Lapecorella M Mariani G Baudo F Caimi MT Federici AB Gringeri A Mannucci PM Santagostino E Marietta M Coppola A Di Minno G Perricone C Schiavulli M Miraglia E Rocino A Zanon E Gagliano F 《Transfusion medicine (Oxford, England)》2011,21(4):280-284
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Cecchi PC Billio A Colombetti V Rizzo P Ricci UM Schwarz A 《Clinical neurology and neurosurgery》2008,110(1):75-79
Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma arising from and confined to the neuraxis. It represents about 3-4% of all primitive brain neoplasms and is mainly located in deep supratentorial regions. A ventricular involvement is quite frequent, but in the vast majority of cases it is secondary to an extension from a subependymal location. Amongst the primary ventricular forms occasionally reported, a choroid plexus origin is extremely rare; to date, only three cases have been described in the English literature. We report the case of a 71-year-old left-handed woman admitted to our department after a progressive 2-week history of confusion, motor speech disturbances and left hemiparesis. A brain MRI scan displayed an intraventricular lesion located in the right atrium, about 2.5cm in its major axis, homogeneously enhancing after gadolinium administration, surrounded by edema in the homolateral deep hemispheric region; the main diagnostic hypothesis was meningioma. She underwent a parieto-occipital craniotomy and a navigation-assisted posterior parietal transcortical approach, achieving complete removal of the intraventricular lesion originating from the choroid plexus. The histological diagnosis was of high-grade diffuse large B-cell lymphoma. Both an MRI scan of the entire craniospinal axis and a thoracic and abdominal CT scan showed no other neoplastic lesions; a bone marrow biopsy was normal; a final diagnosis of primary central nervous system lymphoma was made. CSF cytological analysis did not show any signs of lymphoma dissemination. Adjuvant chemotherapy with methotrexate was administered, and at the last follow-up (26 months) our patient is clinically and radiologically disease-free. Primary choroid plexus lymphoma is a very rare tumor that should be included in the differential diagnosis of intraventricular neoplasms. It usually occurs in the lateral ventricles (with a predilection for the atrium) of adult people (>50 years of age), apparently with a male prevalence. Generally, the radiological picture mimics that of a meningioma, despite the fact that meningiomas usually reach a greater volume before clinical onset. Surgery is almost always necessary to obtain an adequate tissue sample and frequently leads to a radical removal of the lesion. Low-grade marginal zone B-cell, T-cell and high-grade diffuse large B-cell (present case) forms have been described. With a proper adjuvant therapy a relatively good outcome is observed. 相似文献