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101.
Satinder P. Singh Akash D. Aggarwal Surinder S. Oberoi Krishan K. Aggarwal Abhininder S. Thind Diwan S. Bhullar Didar S. Walia Preetinder S. Chahal 《Journal of Forensic and Legal Medicine》2013,20(1):14-18
India is an agriculture based country with Punjab as one of the leading food grain producing states. There is an ever increasing burden to feed the growing population. This has led to over-usage of pesticides which on one hand has contributed significantly to increase the crop yield while on the other hand has led to sharp increase in the poisoning cases in the region. The present study was undertaken to study the deaths related to poisoning in Malwa region of Punjab in 2010 with a view to assess the pattern, trends and incidence of poisoning in relation to age, sex, area, season and type of poison used. These constituted 17.6% of all the unnatural deaths. From the available data the mortality rate from poisoning in Patiala district comes to 60 per million; whereas for males it is 81 per million and for females it is 35 per million. The mortality rate from poisoning in urban population is 78 per million whereas in rural population it is 50 per million. The results of the present study have been compared to those from India and around the world. 相似文献
102.
103.
Mechanistic insights of intestinal absorption and renal conservation of folate in chronic alcoholism
Nissar Ahmad Wani Shilpa Thakur Rauf Ahmad Najar Ritambhara Nada Krishan Lal Khanduja Jyotdeep Kaur 《Alcohol》2013
Folate mediated one-carbon metabolism is of fundamental importance for various cellular processes, including DNA synthesis and methylation of biological molecules. Due to the exogenous requirement of folate in mammals, there exists a well developed epithelial folate transport system for regulation of normal folate homeostasis. The intestinal and renal folate uptake is tightly and diversely regulated and disturbances in folate homeostasis like in alcoholism have pathological consequences. The study was sought to delineate the regulatory mechanism of folate uptake in intestine and reabsorption in renal tubular cells that could evaluate insights of malabsorption during alcoholism. The folate transporters PCFT and RFC were found to be associated with lipid rafts of membrane surfaces in intestine and kidney. Importantly, the observed lower intestinal and renal folate uptake was associated with decreased levels of folate transporter viz. PCFT and RFC in lipid rafts of intestinal and renal membrane surfaces. The decreased association of folate transporters in lipid rafts was associated with decreased protein and mRNA levels. In addition, immunohistochemical studies showed that alcoholic conditions deranged that localization of PCFT and RFC. These findings could explain the possible mechanistic insights that may result in folate malabsorption during alcoholism. 相似文献
104.
Annu Mudgal Krishan Kumar Catherine Mollereau Santosh Pasha 《Chemical biology & drug design》2016,87(6):885-894
Methionine‐enkephalin‐Arg‐Phe is an endogenous amphiactive analgesic peptide. Neuropeptide FF, on the other hand, is reported for its role in opioid modulation and tolerance development. Based on these reports, in the present study we designed a chimeric peptide NPYFa (YGGFMKKKPQRFamide), having the Met‐enkephalin (opioid) and PQRFamide sequence of neuropeptide FF, which can then target both the opioid and neuropeptide FF receptors. We hypothesized that the chimeric peptide so designed would have both analgesic properties and further aid in understanding of the role of neuropeptide FF in the development of opiate tolerance. Our studies indicated that NPYFa induced an early onset, potent, dose‐dependent and prolonged antinociception. Additionally, antagonists (MOR, KOR, and DOR) pretreatment studies determined a KOR‐mediated antinociception activity of the ligand. Further, in vitro binding studies using the Eu‐GTP‐γS binding assay on cell lines expressing opioid and NPFF receptors showed binding to both the opioid and neuropeptide FF receptors suggesting a multiple receptor binding character of NPYFa. Moreover, chronic (6 days) treatment with NPYFa exhibited an absence of tolerance development subsequent to its analgesia. The current study proposes NPYFa as a potent, long‐acting antinociceptor lacking tolerance development as well as a probe to study opioid analgesia and the associated complex mechanisms of tolerance development. 相似文献
105.
A cephalometric study of mandibular cortical bone thickness in dentulous persons and denture wearers
Pete E. Lestrel Krishan K. Kapur Howard H. Chauncey 《The Journal of prosthetic dentistry》1980,43(1):89-94
Cephalometric measurements of the cortical thickness of the inferior mandibular border and the inferior aspect of the mandibular symphysis were compared in two groups of subjects, one with complete dentition and the other wearing complete maxillary and mandibular dentures. Although the cortical thickness of the inferior mandibular border increased slightly with age in both dentition groups, the cortical thickness was significantly less in denture groups than in their respective dentition groups. The opposite was true with the cortical thickness of the inferior aspect of the mandibular symphysis; a decrease in thickness was noted with age, and a slight increase in thickness was noted with edentulousness. The results suggest that bone remodeling can be expected at sites distant from the residual ridge in denture wearers. 相似文献
106.
107.
Mamta Kalra Gopal Krishan Khuller Ajay Grover Digambar Behera Ajay Wanchu Indu Verma 《Diagnostic microbiology and infectious disease》2010
We evaluated the diagnostic potential of a cocktail of 4 antigens encoded by regions of difference (RD) 1 and 2 of Mycobacterium tuberculosis, that is, early secretory antigenic target-6, culture filtrate protein-10 (CFP-10), CFP-21, and mycobacterial protein from species tuberculosis-64 (MPT-64) on the basis of antigen and antibody detection by enzyme-linked immunosorbent assay. Parallel detection of antigens and antibodies in the serum samples of pulmonary tuberculosis (PTB) patients resulted in higher sensitivity as compared to either of the single tests in both smear-positive (90%) and smear-negative (60%) PTB patients. In addition, combined detection of antigens and antibodies in the fluids of extrapulmonary tuberculosis (EPTB) patients could detect >90% of the patients with high specificity. These results demonstrate the ability of the combination of antigen and antibody detection assays based on the cocktail of RD antigens to diagnose a substantial number of PTB and EPTB cases with high specificity. 相似文献
108.
Actinomycotic conjunctivitis is usually unilateral and secondary to canaliculitis. We report an unusual case of bilateral actinomycotic blepharokeratoconjunctivitis in the absence of canaliculitis. Keratitis occurred without any preceding ocular trauma. Both eyes had remissions and relapses in response to the antibiotic-steroid drops. Diagnosis of A. israelii infection was made on the basis of Gram staining, culture and biochemical characteristics. Complete excision of the conjunctival ulcer along with penicillin therapy resulted in cure. This case highlights that microorganisms of the order Actinomycetales should be considered in the differential diagnosis if conjunctivitis or keratitis shows a waxing and waning course. 相似文献
109.
Shahin A. Hunnargi Ritesh G. Menezes Tanuj Kanchan Stany W. Lobo Selma Uysal N.G. Herekar Kewal Krishan R.K. Garg 《Journal of Forensic and Legal Medicine》2009,16(2):56-58
Sex determination is an important initial step in forensic investigation of unknown human skeletal remains. The present analysis is an attempt to determine the sex of the sternum using sternal index as a parameter in a Maharashtrian population of India. Sternal index is calculated in 115 adult sternums of confirmed sex (75 male and 40 female) for sexual dimorphism. The sternal index is derived by dividing the length of manubrium by the length of mesosternum and multiplying it by 100. Although the sternal index is found to be significantly higher in females, the analysis suggests that sex determination cannot be made conclusively from the sternal index in the Maharashtra region of western India. The study further concludes that the applicability of Hyrtl’s law in sex determination is limited. 相似文献
110.
A cross-sectional study was carried out on one thousand school children studying in three public schools of Delhi and Haryana between 10 to 17 year age group over the period of one year (2001-02). It aimed in studying under diagnosis of asthma in school children and its related factors. Questionnaires including details of medical, social, environmental factors precipitating asthma were filled by the parents and class teachers. Pulmonary function test (PFT) was performed. Based on questionnaires and PFT results, children were grouped as labeled and unlabeled asthmatics. Cough was found to be equally prevalent in both the groups while wheezing and shortness of breath were independent and significant factors associated with getting a physician diagnosis. 相似文献