自酸蚀剂材料在口腔修复正畸托槽粘接中的应用

目的：总结近年有关自酸蚀剂粘接正畸托槽的现状。方法：由作者应用计算机检索万方数据库中与使用自酸蚀剂粘接正畸托槽有关的文献,检索时限为2000-09/2010-08。检索关键词：自酸蚀剂;托槽;抗剪切强度。纳入标准：①选入针对性强,相关度高的文献。②排除一些重复性研究。对资料进行初审,并查看每篇文献后的引文。结果：共20篇文献符合标准,自酸蚀剂粘接剂与传统釉质粘接剂比较,正畸托槽的抗剪切强度相近。两种方法在托槽脱落后的釉质粘接材料残留无显著差异。结论：自酸蚀剂与传统釉质酸蚀粘接剂比较,其抗剪切强度可靠,粘接剂残留指数低,能满足粘接正畸托槽的需要。     

自酸蚀剂材料在口腔修复正畸托槽粘接中的应用

目的:总结近年有关自酸蚀剂粘接正畸托槽的现状.方法:由作者应用计算机检索万方数据库中与使用自酸蚀剂粘接正畸托槽有关的文献,检索时限为2000-09/2010-08.检索关键词:自酸蚀剂;托槽;抗剪切强度.纳入标准:①选入针对性强,相关度高的文献.②排除一些重复性研究.对资料进行初审,并查看每篇文献后的引文.结果:共20篇文献符合标准,自酸蚀剂粘接剂与传统釉质粘接剂比较,正畸托槽的抗剪切强度相近.两种方法在托槽脱落后的釉质粘接材料残留无显著差异.结论:自酸蚀剂与传统釉质酸蚀粘接剂比较,其抗剪切强度可靠,粘接剂残留指数低,能满足粘接正畸托槽的需要.     

Endothelial progenitor cells modulated by IL-1β in multiple organ dysfunction syndrome in porcine

Objective To investigate the modulation of EPCs by interleukin 1β (IL-1β) and p38 mitogen activated protein kinase (p38MAPK) and the pathogenesis resulting from their dysdifferenfiation after trauma.Method Thirty pigs were divided into a control group (n = 15) and a multiple organ dysfimction syndrome (MODS) group (n = 15), the latter of which were subjected to a "two-hit" injury including hemon'hagic shock and endotoxemia. Phosphorylation of p38MAPK in peripheral blood mononuclear cells was monitored by western blotting. The concentration of IL-1β in peripheral blood plasma was determined by ELISA and the numbers of EPCs with FCM in peripheral blood plasma were monitored. The morbidity rates in the two groups were compared by chi square test. The levels of phosphorylation of p38MAPK in peripheral blood mononuclear cells, the concentmtions of IL-1β in peripheral blood plasma and the numbers of EPCs in the peripheral blood were compared between groups using with Student's t lest. Results The level of p38MAPK phosphorylation was more augmented and the concen-tration of IL-1β higher in peripheral blood mononuelear cells and plasma from MODS pigs compared with those from control pigs; nevertheless the mauler of EPC conspicuously decreased in the peripheral blood (P <0.01). The morbidity rate in the MODS group was much higher than that in the control group (P < 0.01). There were fewer EPCs in the peripheral blood of animals in group M than in the peripheral blood of animals in group C (P <0.01). Conclusions p38MAPK phosphorylation is important for the pathogenesis of MODS. p38MAPK phospho-rylation might cause the concentration of IL-1β in the peripheral blood plasma to rise and could cause a drop in the numbers of EPCs, thereby aggravating the inflanmmatory reaction in MODS.     

内皮祖细胞在创伤后多器官功能障碍中的变化及意义

Objective To investigate characteristics of changes in bone marrow endothelial progenitor cells (EPCs) and implications on multiple organ dysfunction syndrome (MODS) as a result of trauma.Methods Eighteen mini-pigs were randomized into two groups: MODS group (n=9) and control group (n=9).The animal models of MODS were reproduced by "two-hit" injury with hemorrhagic shock and lipopolysaccharide (LPS) injection.Bone marrow and peripheral blood of them were collected at five time points: normal condition (T1), before injection of LPS (T2), and 0 (T3), 24 (T4) and 48 hours (T5) after injection of LPS.Erythrocytic lysate was added to the samples, and the number of leucocytes in every sample was counted.The rate of EPCs in each sample was determined by flow cytometry.Number of EPCs in bone marrow and peripheral blood were calculated, and the results were analyzed statistically.Results The number of EPCs (×106/L) in bone marrow of control group at T1-5 was 7.64±0.68,7.32±0.55, 7.58±1.13, 7.77±0.70, and 7.88±0.84, respectively, and in peripheral blood control group was 3.54±0.26,4.06±0.64, 3.74±0.55, 3.61±0.37, and 3.98±0.63, respectively.The number of EPCs (×106/L) in bone marrow in the experimental group was 7.45 ± 1.55, 6.58 ± 0.80, 11.27 ± 1.20, 10.88±1.15, and 8.36 ± 2.88, respectively.The number of EPCa (× 106/L) in peripheral blood in the experimental group was 3.21±0.48, 8.71±2.04, 5.98±0.77, 1.27±0.91, and 2.14±0.96, respectively.The number of EPCs in bone marrow of experimental group was larger than that of control group at T3, T4, T5.The number of EPCs in the experimental group in peripheral blood was larger than that of control group at T2, T3, T4, T5.The number of EPCs in bone marrow was larger than that in peripheral blood at every time point (all P＜0.05).Conclusion The number of EPCs in peripheral blood elevates sharply in the earlier period, then plummetes quickly during MODS after a trauma.While the number of EPCs in bone marrow descends mildly at first, then rises obviously.Along with the aggravation of MODS, a declination of EPCs in bone marrow emerges.The change in bone marrow EPCs plays an important role in recovery of MODS.     

四种商品金钱草的辨析及鉴别

目前按金钱草销售使用的中药共有4种，通过调研，对金钱草、广金钱草、连钱草和聚花过路黄4种商品金钱草的名称、来源和功效进行了考证，同时对4种金钱草的药材性状特征进行了较系统的描述和比较。其中金钱草（过路黄）系《中国药典》规定的正品，广金钱草、连钱草2种分别按不同药名收栽于《中国药典》，另一种聚花过路黄则为金钱草的混伪品。     

基于移动用户位置的信息服务中的访问控制模型研究综述

在实际生活中,随着人们所处空间位置的变化,其扮演的角色也会相应发生改变.基于位置的服务作为IT信息服务的重要内容,它根据用户所处空间位置向其提供在当前环境下所需的数据信息.为了保护隐私,保证数据资源不被非法利用,迫切需要对基于移动用户位置的信息服务中的访问控制模型技术进行研究.对现有的具有代表性的空间访问控制模型作了介绍,并进行了分析比较,探讨了在空间访问控制模型的进一步研究中需要解决的关键问题.     

LEEP治疗宫颈高度上皮内瘤样病变临床及近期疗效观察

目的 探讨宫颈电环圈切除术（LEEP）在对宫颈高度上皮内瘤样病变的治疗价值。方法 对2004年9月。2006年10月在妇科门诊就诊的患者行液基细胞学（TCT）筛查，TCT结果异常（≥ASC-US）者在阴道镜下活检，病理结果为CANⅡ、CINⅢ的患者共为78例，均采用LEEP行宫颈锥形切除术，切除组织送病理检查，术后1个月、2个月随访，术后每3个月行TCT细胞学检查，连续2次细胞学阴性后每6个月行TCT检查和高危型HPV检测，细胞学阳性和（或）HPV阳性者，阴道镜检查并在阴道镜图象异常部位取活检送病理。结果 LEEP治疗CANⅡ、CINⅢ治愈率为97．43％，术后1年复发率为2．70％。治疗CIN Ⅱ57例，切缘全部为阴性，治愈率为1130％，随访3—21个月，其中12个月后复发1例，复发率为1．75％。LEEP锥切治疗CINⅢ／21例，切缘阴性16例，随访3—18个月，复发1例。切缘阳性5例，4例行全子宫切除术，1例随访12个月无复发，CINⅢ治愈率为90．48％，术后1年复发率为4．76％。结论 LEEP治疗CINⅡ、CINⅢ治愈率高，术后1年复发率低，近期疗效好，但需长期随访。     

四川省11021名居民食管癌普查结果分析

目的:了解食管癌高发区人群食管癌及癌前病变的患病情况,达到早诊早治的目的.方法:在食管癌高发地区,采取整群随机抽样的方法选择至少1个乡或村作为筛查对象,对40～69岁人群采取内镜下碘染色及指示性活检技术进行筛查,并经病理确诊.结果:全省合计筛查11 021人,筛查率为100.19％;食管重度异形增生(重增)/原位癌及以上患者检出率为1.52％(168/11 021),早诊率为67.86％(114/168),治疗率为67.26％(113/168).食管轻度增生检出率为4.76％(525/11 021),中度增生检出率为1.65％(182/11 021),重增/原位癌检出率为0.97％(107/11 021),黏膜内癌检出率为0.05％(6/11 021),黏膜下癌检出率为0.01％(1/11 021),中晚期浸润癌检出率为0.49％(54/11 021),食管癌检出率为0.55％(61/11 021).各项目点轻、中和重度增生的检出率之间差异有统计学意义,P＜0.05;食管癌的检出率差异无统计学意义,P=0.846.结论:食管癌高发区居民中存在一定数量的癌前病变患者,对该部分人群进行食管癌普查,并进行癌症综合知识宣传,是做好食管癌二级预防的关键.     

Endothelial progenitor cells modulated by IL-1β in multiple organ dysfunction syndrome in porcine

Objective To investigate the modulation of EPCs by interleukin 1β (IL-1β) and p38 mitogen activated protein kinase (p38MAPK) and the pathogenesis resulting from their dysdifferenfiation after trauma.Method Thirty pigs were divided into a control group (n = 15) and a multiple organ dysfimction syndrome (MODS) group (n = 15), the latter of which were subjected to a "two-hit" injury including hemon'hagic shock and endotoxemia. Phosphorylation of p38MAPK in peripheral blood mononuclear cells was monitored by western blotting. The concentration of IL-1β in peripheral blood plasma was determined by ELISA and the numbers of EPCs with FCM in peripheral blood plasma were monitored. The morbidity rates in the two groups were compared by chi square test. The levels of phosphorylation of p38MAPK in peripheral blood mononuclear cells, the concentmtions of IL-1β in peripheral blood plasma and the numbers of EPCs in the peripheral blood were compared between groups using with Student's t lest. Results The level of p38MAPK phosphorylation was more augmented and the concen-tration of IL-1β higher in peripheral blood mononuelear cells and plasma from MODS pigs compared with those from control pigs; nevertheless the mauler of EPC conspicuously decreased in the peripheral blood (P <0.01). The morbidity rate in the MODS group was much higher than that in the control group (P < 0.01). There were fewer EPCs in the peripheral blood of animals in group M than in the peripheral blood of animals in group C (P <0.01). Conclusions p38MAPK phosphorylation is important for the pathogenesis of MODS. p38MAPK phospho-rylation might cause the concentration of IL-1β in the peripheral blood plasma to rise and could cause a drop in the numbers of EPCs, thereby aggravating the inflanmmatory reaction in MODS.     

重组人脑利钠肽治疗急性心力衰竭32例临床观察

目的探讨冻干重组人脑利钠肽(rhBNP)治疗急性心力衰竭的疗效和安全性。方法32例急性心力衰竭患者随机分为两组,rhBNP组(n=15):先以rhBNP 1.5μg/kg静脉冲击后,再以0.007 5μg.kg-1.min-1连续静脉滴注;对照组(n=17)静脉持续泵注硝普钠。记录两组治疗前后呼吸困难程度、全身情况、左室射血分数(EF)和E/A指数等。rhBNP的安全性评估采用治疗药前后定期测量血压、心率,复查血电解质及肾功能,并对所有不良事件进行记录。结果治疗72h后rhBNP组呼吸闲难和临床状况好转率优于对照组(P<0.05);rhBNP组治疗后左室收缩舒张功能指数较对照组明显改善(P<0.05),rhBNP组未发生药物相关的不良事件。结论rhBNP能改善急性心力衰竭患者的呼吸困难程度和临床状况,心脏超声提示心脏收缩舒张功能明显改善,治疗安全可靠。