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Emma T. Callegari Sepehr N. Tabrizi Jan Pyman Marion Saville Alyssa M. Cornall Julia M.L. Brotherton Suzanne M. Garland 《Vaccine》2014
Objectives
This study aimed to determine human papillomavirus (HPV) genotypes present in biopsy sections from young women of vaccine eligible age living in Victoria, Australia, with confirmed cervical intraepithelial neoplasia grade 3 (CIN3) or adenocarcinoma in situ (AIS) using laser capture microdissection (LCM).Methods
Histologically confirmed CIN3 or AIS positive biopsies from vaccine eligible women (born after 30th June 1981, n = 169), between May 2011 and March 2013, were identified. CIN3 or AIS lesions were isolated from biopsy material using LCM, and the HPV genotypes present in whole tissue sections (WTS) as well as LCM-isolated lesion tissue were determined by a sensitive reverse hybridisation assay; RHA kit HPV SPF10-LiPA25, version 1 (Labo Bio-medical Products, Rijswijk, The Netherlands).Results
One hundred and sixty-eight cases were shown to be HPV positive (99%), of which 20 (12%) had more than one HPV genotype detected using WTS-PCR. Evaluation by LCM of individual biopsies with mixed infections showed 18 cases (90%) had only one HPV genotype associated with each CIN3 lesion. HPV 16 was the most common HPV type, found in 95/168 cases (57%).Conclusion
LCM-PCR allowed us to confirm the presence of a single HPV genotype associated with each biologically separate CIN3 lesion, supporting the theory that only one virus type causes each independent CIN lesion. LCM will provide an important tool in assessing vaccine effectiveness in HPV vaccine programs. 相似文献56.
Andrew G. Matthew Shabbir M. H. Alibhai Tal Davidson Kristen L. Currie Haiyan Jiang Murray Krahn Neil E. Fleshner Robin Kalnin Alyssa S. Louis B. Joyce Davison John Trachtenberg 《Quality of life research》2014,23(8):2309-2317
Purpose
To identify the health-related quality of life (HRQoL) domains that radical prostatectomy (RP) impacts most negatively and to define the recovery of these domains over 30 months of observation.Patients and methods
A total of 1,200 RP patients completed the Patient-Oriented Prostate Utility Scale-Psychometric (PORPUS-P; range 0–100, higher is better), a prostate cancer-specific HRQoL measure, prior to RP and at 0–3 (T1), 3–9 (T2), 9–18 (T3) and 18–30 (T4) months post-RP. HRQoL changes were examined using paired t tests and a mixed-effect growth curve model. Multivariable analyses were performed to investigate demographic and treatment factors predicting the change in HRQoL.Results
Mean baseline PORPUS-P score, 83.1, fell to 66.5 (p < 0.001) at T1. Over time HRQoL improved but did not return to baseline (T4 mean 76.4, p < 0.001). Domain analysis revealed that sexual function (p < 0.001), sexual drive (p < 0.001), energy (p = 0.001) and bladder control (p < 0.001) failed to return to baseline at T4. Sexual function demonstrated the greatest impairment overall. The multivariable model revealed Black men experienced greater losses in global HRQoL compared with White men (coefficient ?2.77, 95 % CI ?5.00 to ?0.54, p = 0.015). High baseline HRQoL, pro-erectile aid use and bilateral nerve-sparing were significantly associated with smaller reductions in HRQoL post-RP.Conclusion
Overall HRQoL, sexual drive, sexual function, energy and bladder control do not return to preoperative levels within 30 months post-RP. Black patients experience the greatest reductions in HRQoL. HRQoL losses may be ameliorated by use of pro-erectile aids. These findings help to identify at-risk patient populations and inform survivorship programs. 相似文献57.
Dong Li Rebecca C. Ahrens‐Nicklas Janice Baker Vikas Bhambhani Amy Calhoun Julie S. Cohen Matthew A. Deardorff Alberto Fernández‐Jaén Benjamin Kamien Mahim Jain Fiona Mckenzie Mark Mintz Constance Motter Kirsten Niles Alyssa Ritter Curtis Rogers Maian Roifman Sharron Townshend Catherine Ward‐Melver Samantha A. Schrier Vergano 《American journal of medical genetics. Part A》2020,182(9):2058-2067
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Jansen N. Seheult Nancy M. Dunbar John R. Hess Erin E. Tuott Mohammad Bahmanyar Jessica Campbell Magali Fontaine Jenna Khan Ara Ko Jian Mi Michael F. Murphy Tara Nykoluk Jessica Poisson Jay S. Raval Andrew Shih Jason L. Sperry Julie Staves Michelle Wong Matthew T. S. Yan Alyssa Ziman Mark H. Yazer The Biomedical Excellence for Safer Transfusion collaborative 《Transfusion》2020,60(11):2517-2528
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Kevin Robertson Alan Landay Sachiko Miyahara Alyssa Vecchio Mary Clare Masters Todd T. Brown Babafemi O. Taiwo 《Journal of neurovirology》2020,26(1):107-113
The AIDS Clinical Trials Group (ACTG) study A5303 investigated the associations between neuropsychological performance (NP) and inflammatory biomarkers in HIV-infected participants. Fifteen NP tests were administered at baseline and week 48 to 233 ART naïve participants randomized to maraviroc- or tenofovir-containing ART. Neurocognition correlated modestly with markers of lymphocyte activation and inflammation pre-ART (percent CD38+/HLA-DR+(CD4+) (r = − 0.22, p = 0.02) and percent CD38+/HLA-DR+(CD8+) (r = − 0.25, p = 0.02)), and with some monocyte subsets during ART (r = 0.25, p = 0.02). Higher interleukin-6 and percent CD38+/HLA-DR+(CD8+) were independently associated with worse severity of HIV-associated neurocognitive disorders (HAND) (p = 0.04 and 0.01, respectively). More studies to identify HAND biomarkers are needed. 相似文献