全文获取类型
收费全文 | 4760篇 |
免费 | 323篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 148篇 |
妇产科学 | 94篇 |
基础医学 | 716篇 |
口腔科学 | 57篇 |
临床医学 | 560篇 |
内科学 | 953篇 |
皮肤病学 | 64篇 |
神经病学 | 520篇 |
特种医学 | 83篇 |
外国民族医学 | 3篇 |
外科学 | 521篇 |
综合类 | 33篇 |
一般理论 | 6篇 |
预防医学 | 540篇 |
眼科学 | 138篇 |
药学 | 309篇 |
中国医学 | 12篇 |
肿瘤学 | 279篇 |
出版年
2024年 | 13篇 |
2023年 | 29篇 |
2022年 | 90篇 |
2021年 | 106篇 |
2020年 | 78篇 |
2019年 | 110篇 |
2018年 | 124篇 |
2017年 | 78篇 |
2016年 | 99篇 |
2015年 | 119篇 |
2014年 | 139篇 |
2013年 | 212篇 |
2012年 | 352篇 |
2011年 | 355篇 |
2010年 | 172篇 |
2009年 | 179篇 |
2008年 | 338篇 |
2007年 | 340篇 |
2006年 | 318篇 |
2005年 | 325篇 |
2004年 | 273篇 |
2003年 | 238篇 |
2002年 | 234篇 |
2001年 | 56篇 |
2000年 | 54篇 |
1999年 | 61篇 |
1998年 | 52篇 |
1997年 | 30篇 |
1996年 | 37篇 |
1995年 | 30篇 |
1994年 | 19篇 |
1993年 | 23篇 |
1992年 | 32篇 |
1991年 | 30篇 |
1990年 | 22篇 |
1989年 | 21篇 |
1988年 | 20篇 |
1987年 | 21篇 |
1986年 | 13篇 |
1985年 | 22篇 |
1984年 | 18篇 |
1983年 | 11篇 |
1982年 | 13篇 |
1979年 | 13篇 |
1978年 | 11篇 |
1977年 | 11篇 |
1970年 | 11篇 |
1968年 | 9篇 |
1966年 | 8篇 |
1965年 | 9篇 |
排序方式: 共有5094条查询结果,搜索用时 15 毫秒
61.
B Estour H Bornet M H Bernard M C Fleury C Ardiet J Tourniaire 《Annales d'endocrinologie》1983,44(6):367-370
Serum thyroglobulin (TG) is considered as a useful index of differentiated thyroid carcinoma evolution. Previous studies have suggested that TG levels might be dependent upon oestrogens. Here TG levels were determined in volunteers , free of any thyroid disease, divided into 5 groups according to estrogen level. Results (mean +/- s.d.) indicated that Tg levels in men group A (n = 9): 6,6 +/- 2,8 ng/ml in women undergoing oestroprogestagen treatment group B (n = 10) 3,7 +/- 1,5 ng/ml; in women free of oestroprogestaten treatment group C (n = 10): 5,9 +/- 4,0 ng/ml; in pregnant women group D (n = 40): 4,6 +/- 2,7 ng/ml, and in parturient women group E (n = 4): 7,2 +/- 2,2 ng/ml; were not correlated to estrogen levels. However, in a group where thyroid gland was not carefully examined i.c. a "blood doners group", a difference (p less than 0,005) was found between women (29 +/- 15) and men (14 +/- 9). Sex and estrogen levels there fore do not influence the TG index which as a result can be used in the monitoring of thyroid carcinoma in pregnant women. 相似文献
62.
Agnes B. Hatfield Ph.D. 《Community mental health journal》1991,27(2):95-103
The National Alliance for the Mentally Ill (NAMI) was conceived a decade ago in the tradition of self-organized parents' groups for handicapped and chronically ill children. The character of the organization and its rapid growth are thought to be due to its clear identity as a mental illness group, its control and direction by parents and relatives of people suffering from mental illness, and its relationships with staff and professionals. The author believes that the NAMI movement is at an important juncture in its development and identifies factors that could influence its character in the next decade. 相似文献
63.
64.
Hormonal imprinting takes place perinatally when a hormone and its maturing target receptor meet. As a consequence of imprinting the receptor accomplishes its maturation reaching the binding capacity characteristic to the adult age. In this critical period the presence of foreign molecules which are able to bind to the receptor can cause faulty imprinting with life-long consequences. In the recent years it was cleared that not only receptors are influenced by faulty imprinting, however, also the hormone production of the given cell. In addition imprinting was provoked at non-perinatal periods (adolescence and adult age) in cytogenic organs. In the present experiment the prolonged effect of a non-perinatal imprinting by an antihistamine to the histamine content of white blood cells and glucocorticoid receptors of liver and thymus was studied. Two weeks after 3-day terfenadine treatment at weaning, flow cytometry of peritoneal cells and blood lymphocytes for histamine, and receptor kinetic analysis of dexamethasone binding were done. Histamine content of blood lymphocytes and glucocorticoid receptor density of liver cells were significantly decreased. This means that a short treatment with a H(1)-receptor blocker antihistamine durably influences physiological indexes which were not known till now. This means that not only the acute effects, but the prolonged side-effects must be considered. 相似文献
65.
Neil H Segal Paul Pavlidis William S Noble Cristina R Antonescu Agnes Viale Umadevi V Wesley Klaus Busam Humilidad Gallardo Dianne DeSantis Murray F Brennan Carlos Cordon-Cardo Jedd D Wolchok Alan N Houghton 《Journal of clinical oncology》2003,21(9):1775-1781
PURPOSE: To develop a genome-based classification scheme for clear-cell sarcoma (CCS), also known as melanoma of soft parts (MSP), which would have implications for diagnosis and treatment. This tumor displays characteristic features of soft tissue sarcoma (STS), including deep soft tissue primary location and a characteristic translocation, t(12;22)(q13;q12), involving EWS and ATF1 genes. CCS/MSP also has typical melanoma features, including immunoreactivity for S100 and HMB45, pigmentation, MITF-M expression, and a propensity for regional lymph node metastases. MATERIALS AND METHODS: RNA samples from 21 cell lines and 60 pathologically confirmed cases of STS, melanoma, and CCS/MSP were examined using the U95A GeneChip (Affymetrix, Santa Clara, CA). Hierarchical cluster analysis, principal component analysis, and support vector machine (SVM) analysis exploited genomic correlations within the data to classify CCS/MSP. RESULTS: Unsupervised analyses demonstrated a clear distinction between STS and melanoma and, furthermore, showed that CCS/MSP cluster with the melanomas as a distinct group. A supervised SVM learning approach further validated this finding and provided a user-independent approach to diagnosis. Genes of interest that discriminate CCS/MSP included those encoding melanocyte differentiation antigens, MITF, SOX10, ERBB3, and FGFR1. CONCLUSION: Gene expression profiles support the classification of CCS/MSP as a distinct genomic subtype of melanoma. Analysis of these gene profiles using the SVM may be an important diagnostic tool. Genomic analysis identified potential targets for the development of therapeutic strategies in the treatment of this disease. 相似文献
66.
Pelvis-shoulder dysplasia is a rare focal skeletal dysostosis. We present the long-term follow-up of a patient with this
condition. This patient has severe pelvic dysplasia but no involvement of the scapulae or clavicles. Despite the severity
of the pelvic dysplasia, this man is able to function well. This is the fifth case of pelvis-shoulder dysplasia reported,
but the only one documenting follow-up into adulthood.
Received: 16 July 1997 Accepted: 4 February 1998 相似文献
67.
Outbreak in Alberta of community-acquired (USA300) methicillin-resistant Staphylococcus aureus in people with a history of drug use, homelessness or incarceration 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Canadian Medical Association journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
68.
Yuriko Watanabe Agnes Shiel D. Lindsay McLellan Masaki Kurihara Kentaro Hayashi 《Disability and rehabilitation》2013,35(9):370-378
Purpose: To ascertain the views of families living with TBI patients about the nature of the problems experienced as a result of TBI, and to compare the views of Japanese family members (J-FM) and British family members (B-FM) in order to find out whether there were cultural differences in family response to TBI. Methods: Family members involved in providing care were identified by the patients. Face to face interviews were conducted with all 18 carers in B-FM and four carers in J-FM. The remaining eight carers in J-FM participated in the postal questionnaire. Questionnaires were developed to explore the nature of problems and the involvement of family such as social embarrassment. Results: Problems arising in families were almost the same reported from both groups. However families in B-FM were likely to know more about how to cope with these problems. Family members in J-FM reported more statistically significant increases in social embarrassment than those in B-FM. Conclusion: The preliminary results showed that family members living with TBI patients in both groups had experienced problems. Appropriate rehabilitation services should be developed to help families as well as TBI patients in Japan. 相似文献
69.
Eric A.J. Bleeker Wim H. de Jong Robert E. Geertsma Monique Groenewold Evelyn H.W. Heugens Marjorie Koers-Jacquemijns Dik van de Meent Jan R. Popma Anton G. Rietveld Susan W.P. Wijnhoven Flemming R. Cassee Agnes G. Oomen 《Regulatory toxicology and pharmacology : RTP》2013,65(1):119-125
In recent years, an increasing number of applications and products containing or using nanomaterials have become available. This has raised concerns that some of these materials may introduce new risks for humans or the environment. A clear definition to discriminate nanomaterials from other materials is prerequisite to include provisions for nanomaterials in legislation. In October 2011 the European Commission published the ‘Recommendation on the definition of a nanomaterial’, primarily intended to provide unambiguous criteria to identify materials for which special regulatory provisions might apply, but also to promote consistency on the interpretation of the term ‘nanomaterial’. In this paper, the current status of various regulatory frameworks of the European Union with regard to nanomaterials is described, and major issues relevant for regulation of nanomaterials are discussed. This will contribute to better understanding the implications of the choices policy makers have to make in further regulation of nanomaterials. Potential issues that need to be addressed and areas of research in which science can contribute are indicated. These issues include awareness on situations in which nano-related risks may occur for materials that fall outside the definition, guidance and further development of measurement techniques, and dealing with changes during the life cycle. 相似文献
70.
Bodil Jönsson Malin Ridell Agnes E. Wold 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2013,121(1):45-55
Mycobacterium abscessus is a non‐tuberculous mycobacteria able to cause opportunistic infections in selected patient groups. During the last decades it has emerged as a cause of chronic pulmonary infection in patients with cystic fibrosis (CF). M. abscessus strains exhibit either smooth or rough colony morphology. Strains exhibiting the rough phenotype more often cause pulmonary infections in CF patients than did the smooth ones. Here, we examined phagocytosis and production of cytokines by human peripheral blood mononuclear cells, in response to M. abscessus strains with smooth and rough colony phenotype. The rough isolates all formed multicellular cords, similar to what is observed in Mycobacterium tuberculosis. Monocytes were generally unable to internalize these rough cord isolates, in contrast with the smooth ones. Furthermore, the rough M. abscessus strains induced a distinct cytokine profile differing from that induced by the smooth ones. Rough isolates induced significantly less IL‐10 and tumour necrosis factor compared to smooth strains, but more IL‐1β. Both varieties induced equal amounts of IFN‐γ, IL‐17, IL‐23, IL‐6, IL‐8 and equally little IL‐12. The ability to withstand phagocytosis might be a virulence factor contributing to the capacity of rough M. abscessus strains to give persistent pulmonary infections. 相似文献