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排序方式: 共有210条查询结果,搜索用时 218 毫秒
41.
T. Nakamura A. Abudu H. Murata R.J. Grimer S.R. Carter R.M. Tillman L. Jeys 《European journal of surgical oncology》2013
Aims
The treatment of pelvic soft tissue sarcomas (STS) presents one of the most challenging problems in musculoskeletal oncology because of the complex anatomy of the pelvis, late diagnosis and large tumor size. Our study was designed to determine the outcome and prognostic factors for survival and local recurrence in patients with pelvic STS located deep to the fascia and deemed suitable for curative surgical treatment.Patients and methods
Ninety consecutive pelvic STS patients with at least 5-year possible follow-up from diagnosis were studied. Mean age at diagnosis was 54 years. Mean follow-up and tumor size were 69 months and 13 cm, respectively. Histological grades were grade 3 in 51, grade 2 in 22 and grade 1 in 17 patients. Tumor locations were extra-pelvic or outside pelvic brim (n = 67), intra-pelvic or within pelvic brim (n = 10), and combined or involving both outside and within pelvic brim (n = 13).Result
Surgical treatment was excision in 84 patients and hindquarter amputation in 6 patients. In 84 patients who underwent excision, surgical margin was wide in 21 patients, marginal in 33, and intralesional in 30. Radiotherapy was used for all high grade tumors. Disease-specific survival was 53.3% at 5 years. Local recurrence occurred in 23%. Development of local recurrence was related to surgical margin (p = 0.03). Local recurrence, tumor histological grade and metastasis at diagnosis independently influenced disease-specific survival (p = 0.0008, p < 0.0001, p = 0.02, respectively).Conclusion
The patients with high grade tumors and positive surgical margins represent a particular group with high risk of local recurrence even with radiotherapy. 相似文献42.
I. Pérez-Muñoz R.J. Grimer D. Spooner S. Carter R. Tillman A. Abudu L. Jeys 《European journal of surgical oncology》2014
Introduction
The local treatment option for pelvic Ewing sarcoma (ES) remains uncertain and challenging as surgery is often disabling while radiotherapy alone has a higher risk of local recurrence but not necessarily a worse survival. The aim is to analyse the outcome of patients with pelvic ES after radiotherapy as the primary local treatment in combination with a temporary intrapelvic surgically placed tissue expander (TE) to reduce bowel complications.Materials and methods
20 patients were retrospectively analysed. All patients had neoadjuvant and adjuvant chemotherapy. We identified survival, time to develop local recurrence and metastasis, dose of radiotherapy administered, local complications related to the use of the tissue expander and bowel effects of radiotherapy.Results
The median follow-up was 41 months. 14 patients were stage IIb and six stage III. There were no problems after insertion of the TE and only one patient who developed mild diarrhoea. Local recurrence occurred in six patients. At the last follow-up 12 patients have died from sarcoma, five are disease free and three have had recurrent disease.Conclusions
In this paper we reviewed pelvic Ewing sarcoma with all the special considerations that this entails. We think that tissue expander can be safely used when radiotherapy is chosen to treat pelvic ES. It does appear to prevent bowel problems and is a low morbidity procedure. New treatment approaches should be considered to give a chance of cure to those patients with “bad prognostic” pelvic ES. 相似文献43.
S. Iwata T. Nakamura C.L. Gaston S.R. Carter R.M. Tillman A. Abudu L. Jeys R.J. Grimer 《European journal of surgical oncology》2014
Aims
The aim of this study was to clarify the clinical features and outcomes of diaphyseal osteosarcoma.Methods
Patients with newly-diagnosed high-grade osteosarcoma occurring in the long bone were eligible for this retrospective study. Clinicopathological information was collected from our database and compared with 36 diaphyseal, 405 proximal and 519 distal metaphyseal, and 14 whole bone osteosarcoma patients. Additionally, case–control study matching by age, gender, site, and metastatic status at diagnosis with 1:3 ratio of 36 diaphyseal to 108 metaphyseal osteosarcomas patients was also conducted.Results
Five-year overall survival and metastasis-free survival of the three groups including diaphyseal, metaphyseal, and whole bone osteosarcoma patients showed significant difference (P = .029 and P = .013, respectively), although there is no difference for the survivals between proximal and distal metaphyseal osteosarcoma patients. Case-control study showed that patients with diaphyseal osteosarcomas had a significantly larger tumour (mean 13.5 cm vs 10 cm, P = .026), and demonstrated higher pathologic fracture rate (28% vs 12%, P = .033), superior 5-year metastasis-free survival (74% vs 40%, P = .0068), and slightly better 5-year overall survival (68% vs 46%, P = .074). Prognostic factor analysis showed that a pathologic fracture significantly decreased the survival of the patients with diaphyseal osteosarcoma.Conclusions
The current study showed that diaphyseal osteosarcoma has distinct clinical features from metaphyseal osteosarcoma having an increased risk of pathologic fractures but with favorable survival outcome. 相似文献44.
45.
目的 掌握口岸地区本底小型哺乳动物种群及家、野栖鼠类的动态变化,识别外来物种,预测、预报传疫信息.方法 在本口岸及周边区域6大生态环境中进行调查,对比既往资料进行分析.结果 捕获兔形类1种、啮齿类16种、食虫类2种、食肉类1种、翼手类1种,即5目9科15属19种1022只.并对口岸输入种进行了分析.结论 家栖鼠类褐家鼠为优势种,野栖鼠类大沙鼠为优势种,这两大家、野栖鼠类的代表性种群,其主要传播媒介已发生交换和转移,加之印鼠客蚤的参与是鼠间到人间鼠疫发生的危险因素. 相似文献
46.
Eric Lodewijk Staals MD Andrea Sambri MD Domenico Andrea Campanacci MD Francesco Muratori MD Andreas Leithner MD Magdalena Maria Gilg MD Yair Gortzak MD Michiel Van De Sande MD Edwin Dierselhuis MD Eric Mascard MD Reinhard Windhager MD Philipp Funovics MD Martina Schinhan MD Oleg Vyrva MD Gwen Sys MD Nikolay Bolshakov MD Will Aston MD Panagiotas Gikas MD Thomas Schubert MD Lee Jeys MD Adesegun Abudu MD Marco Manfrini MD Davide Maria Donati MD 《Journal of surgical oncology》2020,122(4):760-765
47.
48.
Coonoor R Chandrasekar Robert J Grimer Simon R Carter Roger M Tillman Adesegun T Abudu 《Journal of orthopaedic surgery and research》2008,3(1):50
Background and aims
Endoprosthetic replacements of the proximal femur are commonly required to treat destructive metastases with either impending or actual pathological fractures at this site. Modular prostheses provide an off the shelf availability and can be adapted to most reconstructive situations for proximal femoral replacements. The aim of this study was to assess the clinical and functional outcomes following modular tumour prosthesis reconstruction of the proximal femur in 100 consecutive patients with metastatic tumours and to compare them with the published results of patients with modular and custom made endoprosthetic replacements. 相似文献49.
One hundred and sixty-one specimens swabbed from as many patients with chronic wounds/ulcers over a period of eight months yielded 3 acid-alcohol fast bacilli (AFB) organisms that slowly grew only at 32°C on Lowenstein-Jensen(LJ) medium producing creamy-yellow colonies between 39 and 45 days post-incubation. Mycobacterial organisms harvested from culture were strongly positive when subjected to both catalase spot test and catalase heat stability test indicating the presence of Mycobacterium ulcerans, the aetiological agent of Buruli ulcer. 相似文献
50.
对我国新疆伊犁维吾尔族,哈萨克族和蒙古族共1375人的指纹白线正常值分布进行了研究。这三个民族的指纹白线出现率分别是23.36%,20.31%和9.2%,并进行了性别,指别和不同民族间差异的比较。 相似文献