全文获取类型
收费全文 | 67111篇 |
免费 | 7022篇 |
国内免费 | 5026篇 |
专业分类
耳鼻咽喉 | 510篇 |
儿科学 | 662篇 |
妇产科学 | 627篇 |
基础医学 | 7630篇 |
口腔科学 | 1335篇 |
临床医学 | 9053篇 |
内科学 | 10225篇 |
皮肤病学 | 637篇 |
神经病学 | 3614篇 |
特种医学 | 2435篇 |
外国民族医学 | 52篇 |
外科学 | 6841篇 |
综合类 | 12232篇 |
现状与发展 | 19篇 |
一般理论 | 5篇 |
预防医学 | 4755篇 |
眼科学 | 1959篇 |
药学 | 7275篇 |
44篇 | |
中国医学 | 3846篇 |
肿瘤学 | 5403篇 |
出版年
2024年 | 281篇 |
2023年 | 1211篇 |
2022年 | 2842篇 |
2021年 | 3558篇 |
2020年 | 2698篇 |
2019年 | 2298篇 |
2018年 | 2352篇 |
2017年 | 2184篇 |
2016年 | 2054篇 |
2015年 | 3145篇 |
2014年 | 3913篇 |
2013年 | 3413篇 |
2012年 | 5257篇 |
2011年 | 5613篇 |
2010年 | 3472篇 |
2009年 | 2732篇 |
2008年 | 3640篇 |
2007年 | 3531篇 |
2006年 | 3423篇 |
2005年 | 3335篇 |
2004年 | 2188篇 |
2003年 | 2085篇 |
2002年 | 1729篇 |
2001年 | 1486篇 |
2000年 | 1488篇 |
1999年 | 1677篇 |
1998年 | 1013篇 |
1997年 | 974篇 |
1996年 | 704篇 |
1995年 | 647篇 |
1994年 | 653篇 |
1993年 | 398篇 |
1992年 | 565篇 |
1991年 | 429篇 |
1990年 | 392篇 |
1989年 | 330篇 |
1988年 | 319篇 |
1987年 | 257篇 |
1986年 | 220篇 |
1985年 | 185篇 |
1984年 | 101篇 |
1983年 | 62篇 |
1982年 | 49篇 |
1981年 | 43篇 |
1980年 | 23篇 |
1979年 | 42篇 |
1978年 | 15篇 |
1977年 | 14篇 |
1975年 | 8篇 |
1936年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
膳食黑米皮抑制高脂诱导的家兔动脉粥样硬化形成及其机制的初步探讨 总被引:1,自引:0,他引:1
目的 探讨膳食黑米皮对高脂诱导的家兔动脉粥样硬化形成的影响及其作用机制。方法 24只雄性新西兰大耳白家兔,按体重随机分为3组,分别饲以正常基础饲料、高脂饲料(含96%基础饲料、0.5%胆固醇、3.5%猪油)、黑米皮饲料(含 91%基础饲料、0.5%胆固醇、3.5%猪油、5%黑米皮),实验期为 60d。用图像分析法测定各组家兔主动脉脂质斑块面积,并分析家兔氧化与抗氧化状态。结果 黑米皮实验家兔的主动脉壁斑块面积较高脂组低66%(P<0.001);黑米皮组实验家兔的主动脉壁8-ohdG含量和血清及主动脉壁中MDA水平也低于高脂组(P<0.05 );而红细胞及主动脉壁中SOD水平和血清α-生育酚含量在两个处理组之间差异无显著性。结论 膳食黑米皮可以抑制高脂诱导的家兔动脉粥样硬化形成,其机制可能与之降低机体氧化应激水平及过氧化脂质生成有关。 相似文献
12.
目的 探讨种植受体血管内皮细胞在抗异种血管移植超急排斥反应 (HAR)方面的意义。方法 选用豚鼠→大鼠移植模型 ,先将分离、培养的大鼠动脉内皮细胞种植于去内皮的豚鼠动脉内壁 ,再将此豚鼠动脉植入大鼠体内 ,观察动脉血栓形成时间 ,并采用免疫组化技术检测了 Ig M、C3在移植后豚鼠动脉壁上沉积的情况。结果 已种植大鼠内皮细胞的豚鼠动脉血栓形成时间 (2 0 .3± 4.42 h)较植入大鼠体内的正常豚鼠动脉 (0 .35± 0 .2 84h)以及单纯去内皮豚鼠动脉血栓形成时间 (0 .16 5± 0 .0 77h)显著延长 (P<0 .0 0 1)。免疫组化结果显示 ,植入大鼠体内的正常豚鼠内皮细胞表面有 Ig M和 C3沉积 ,而预先种植大鼠内皮细胞的豚鼠动脉内壁无 Ig M和 C3沉积。结论 在异种供体血管壁上预先种植受者血管内皮细胞 ,可延长移植的异种供体血管通畅时间 ,该技术可能在抗异种血管移植 HAR方面具有重要意义 相似文献
13.
Single or combined monoclonal antibodies (McAbs) Zh53, Zh820, and Zh2-1 have been used to eliminate malignant clonogenic cells from human bone marrow. The test of cytotoxicity showed that all of these McAbs could express high specific cytotoxic action against HL-60 cells and were selectively complement-dependent cytotoxic to various types of fresh leukemic cells. Clonogenic assay detected that single treatment with antibody and rabbit complement (RC) could reduce clonogenic units of HL-60 cells by more than 2 logs and two treatments reduced clonogenic units by more than 4 logs. However, combination of 2 McAbs could reduce clonogenic units by 4-5 logs. The data suggest that multiple treatments with McAbs and RC or a combination of 2 McAbs are more effective than a single treatment in eliminating clonogenic tumor cells. Treatment of normal human bone marrow with Zh53, Zh2-1 and RC did not produce a loss of normal CFU-GM, but treatment with Zh820 reduced the clonic units of normal CFU-GM by 24%.
相似文献
14.
15.
X Dong M He X Song B Lu Y Yang S Zhang N Zhao L Zhou Y Li X Zhu R Hu 《Diabetic medicine》2007,24(12):1482-1486
AIMS: Our aim was to assess performances of the Cockcroft-Gault and simplified Modification of Diet in Renal Disease (MDRD) formulae in estimating glomerular filtration rate (GFR) in Chinese diabetic populations and their association with vascular risks. METHODS: A total of 1009 patients with Type 2 diabetes were categorized into low estimated GFR groups (GFR < 60 ml/min/1.73 m(2)) and control groups by the two equations. The performances of these formulae were assessed at different stages of kidney function. Carotid artery intima-media thickness (IMT) and the prevalence of diabetic retinopathy or albuminuria were compared among the groups. The ability of these formulae to identify established vascular risk markers using sensitivity, specificity, positive and negative predictive values were also compared. RESULTS: The prevalence of low estimated GFR was 32.7% with the Cockcroft-Gault formula and 5.2% with the MDRD formula, respectively. In low estimated GFR subjects by the MDRD formula, IMT was significantly thicker than those by the Cockcroft-Gault formula (1.2 mm vs. 1.0 mm; P < 0.05), with a higher prevalence of albuminuria (78.4 vs. 52.8%, P < 0.05) and diabetic retinopathy (46.5 vs. 30.5%; P < 0.05). The Cockcroft-Gault formula gave a specificity of 71.7% and a sensitivity of 37.0%, and the MDRD formula gave a specificity of 96.6% and a sensitivity of 7.9% in estimating low GFR relevant for established vascular risks. CONCLUSIONS: These formulae performed differently in Chinese diabetic populations. The simplified MDRD formula is minimally superior to the Cockcroft-Gault formula for its high specificity and positive predictive values in estimating low GFR relevant for vascular risks. 相似文献
16.
以曼氏血吸虫的虫卵和成虫免疫家兔后所产生的特异性抗体,可用以日本血吸虫虫卵、尾蚴和成虫为抗原分别进行的COP,CHR和ELACIEP测出,表明两种人体血吸虫存有显著的交叉抗原成分。应用此种血清交叉反应性,以检测抗异种人体血吸虫的抗体,似有效而可取的,可用以辅助诊断援外回国人员是否感染国外人体血吸虫病。 相似文献
17.
Bent H. Hellum Zhuohan Hu Odd Georg Nilsen 《Basic & clinical pharmacology & toxicology》2009,105(1):58-63
Abstract: The aim of this study was to evaluate in vitro the dose‐dependent induction potential of six commonly used trade herbal products on CYP2C19 and CYP2E1 metabolic activities in cultured human hepatocytes. S‐mephenytoin and chlorzoxazone were used as specific CYP substrates, respectively, and rifampicin was used as a positive induction control for both enzymes. The hepatocytes were exposed to herbal extracts in increasing and biological relevant concentrations for 72 hrs and CYP substrate metabolites were quantified by validated HPLC methodologies. The major findings were that St John's wort was the most potent CYP‐modulating herb, showing a dose‐dependent induction/inhibition of both CYP2C19 and CYP2E1, with induction at low dosages and inhibition at higher. Ginkgo biloba showed an induction/inhibition profile towards CYP2C19 which was similar but weaker than that observed for St John's wort. If cooperative mechanisms are involved is still an open question. Common sage induced CYP2C19 in a log‐linear dose‐dependent manner with increasing concentrations. Common valerian was a weak inducer of CYP2C19, while horse chestnut and cone flower were characterized as non‐inducers of CYP2C19. Only St John's wort showed an inductive effect towards CYP2E1. In addition to St John's wort, Gingko biloba and common sage should be considered as possible candidates for clinically relevant drug‐herb interactions with selected CYP2C19 substrates. 相似文献
18.
我们自2000年10月至2008年12月采用大承气汤加黄连应用与肛周常见疾病术后病人,治疗其术后大小便潴留,里急后重等症状,取得了满意的疗效,现报告如下. 相似文献
19.
8年间剖宫产率及指证变化的临床分析 总被引:3,自引:1,他引:2
近年来,我国各地的剖宫产率均呈明显的上升趋势,部分地区的剖宫产率甚至高达60%。居高不下的剖宫产率已引起了广大产科工作者和全社会的广泛关注。对我院近8年来剖宫产病例的临床资料进行回顾性分析,以寻求剖宫产率逐年上升的原因及探讨降低剖宫产率的途径与方法。 相似文献
20.