90例高血压病患者脑电地形图,脑电图分析

高血压病是脑血管病的主要危险因素 ,为了提高对高血压病早期出现脑功能变化的认识 ,本文测定了 90例原发性高血压病患者的脑电地形图、脑电图 ,现报告如下。1　一般资料90例中 ,男 5 7例 ,女 33例 ;年龄 35～ 82岁 ;病程 3～ 30年。临床表现主要有头痛、头晕、一侧肢体麻木、无力等不适。2　方法采用美国 Galileo全数字化无纸脑电图监测系统及脑电信息处理系统进行监测处理 ,按国际 10 / 2 0电极系统放置 ,参考电极取双耳垂 ,消除眼动、脉搏等伪迹作 16道常规的描记。随机采样 30 S,分 6个频带即 δ(2～ 3.8Hz) ,θ(4～ 7.8Hz) ,α1(8～ …     

抑郁、焦虑对癫(癎)患者健康相关生存质量的影响

Objective To assess health-related quality of life and the mood disorder in adults with epilepsy,and to evaluate factors contributing to the quality of life.Methods Quality of life was measured by the Quality of Life in Epilepsy Inventory(QOLIE-31)and the World Health Organization Quality of Life Assessment-Bref(WHOQOL-BREF).Psychotic conditions were evaluated by Self-rating Depressive Scale (SDS)and Self-rating Anxious Seale(SAS).The multivariate analysis was used to assess the determinant factors.Results The study included 141 epilepsy patients in the teat group and 59 sex,age,and education matched normal controls. WHOQOL-BREF scores in the physical and psychological aspects were significantly lower in epilepsy patients(12.7 ±1.8 and 12.4±1.9,respectively)than those in the normal controls(15.1 ±2.3 and 13.9 ±1.9,respectively,t value were 11.75 and 8.625.both P<0.05).The survey reported that 57.4 % of the epilepsy patients suffered with depression.and 39.7 % anxiety.The patients with both anxiety and depression scored lower in all aspects in QOLIE survey except medical effect.Multivariate analysis showed that factors that effect the overall quality of life in order were anxiety.depression and disease duration.Conclusion Our results support that complications of anxiety and depression and long disease duration are key factors affecting the quality of life in epilepsy patients.     

有关成年癫患者生活质量的研究

癫是一种反复发作性慢性脑病 ,即使坚持正规药物治疗 ,仍有 2 0 %的患者发作难以控制。癫发作的不可预知性是造成癫患者社会心理功能障碍的一个重要原因 ,长期服药及药物不良反应造成巨大的心理压力及沉重的经济负担 ,在升学和就业等问题上受到的社会歧视 ,都严重影响了患者的生活质量。现代医学对癫治疗的目的不仅局限于控制发作 ,还要改善患者的总体健康状况 ,提高患者的生活质量 (qualityoflife ,QOL)。1　生活质量的定义生活质量原是一个社会学概念 ,被引入医学研究领域时 ,它是相对于生命数量 (寿命 )而言的 ,即与健康相关的…     

全面性发作癫(癎)患者记忆功能与海马质子磁共振波谱改变的相关性分析

Objective To investigate the features of the memory function disturbance in patients of generalized seizures and the correlation between the memory function and proton magnetic resonance spectroscopy(1H-MRS).Methods The clinical memory scale of 45 general seizures and 20 normal age and sex-matched controls wss measured and a1 H-MRs was performed in the bilateral hippoeampal.The levels of NAA.Cho.Cr and the ratios of NAA/Cr+Cho were compared between these two groups.Meanwhile,tHe correlation coefficients was calculated and the results of clinical memory scale scoreB and the level of NAA,Cho.Cr and the ratios of NAA/Cr+Cho in groups were compared.Results As compared with the controls.the scores of pointing memory(17.19±5.86),associational learning(20.00±6.77),image free memory(18.44±6.62),association memory of portrait(13.19±6.62)and memory quotient (MQ,79.07±20.20)excepts insignificant figure recognition wcrc significandy decreased in patients of seizures(t=4.794-10.224,all P<0.01);The scores of scale and MQ of both the group of patients who wok antiepileptic drugs(AEDs)and the group of patients whose frequency exceeded 3 per month were significantly lower than the group who didn't take AEDs and the group whose frequency was lower than 3 per month(t=3.267-6.537,all P<0.01).The volumes of hippocampal formations(2.45 ±0.25 on left and 2.56 ±0.31 on right),the level of NAA(12.93 ±1.73 on left and 11.88 ±1.69 on right),Cho(15.02 ±0.86 on left and 14.94 ±0.96 on right),Cr(11.86 ±0.71 on left and 10.71 ±0.42 on right)and the ratios of NAA/Cr+Cho(0.48 ±0.08 on left and 0.39 ±0.07 on riht)in the group of pailents of generalized seizures were significantly difference than those in the controls(t=4.103-5.768,all P<0.01).Patients with seizures showed significant correlation between tlle scores of all items.MQ in clinical memory scale and NAA,NAA/Cr+Cho ratio(r=0.489-0.727,all P<0.01),and inverse correlation between the scores and MQ and Cho of in the bilateral hippocampal(r=-0.604-0.484,all P<0.01).However,there was no correlation between the scores and MQ and Cr of in the bilateral hippocampal.Condusions The patients of the general seizures do have the problem of the disturbance of short-term memory including acoustic memory and some visual memory.Both the high frequency of seizure and AEDs could affect the short-term memory function.The correlation between the scores of all the items and MQ in clinical memory scale proved that lack of nerve cell and hyperplasia of gliocyte was one of the reasons of the short-term memory disorder in epileptic.     

脑血灵颗粒对实验性脑出血大鼠脑细胞凋亡及Bcl-2、CasPase-3表达的影响

目的观察脑血灵颗粒对脑出血大鼠脑细胞凋亡及Bcl-2、半胱氨酰天冬氨酸特异性蛋白酶-3(Cas-pase-3)表达的影响。方法以自体血制作大鼠脑出血模型,实验组给予大剂量脑血灵颗粒,华佗再造丸为阳性对照组,模型对照组和假手术组给予生理盐水,通过TUNEL法检测原位凋亡细胞,免疫组化、原位杂交、Western-blot检测Bcl-2、Caspase-3等凋亡相关基因的表达。结果在脑出血造模后7d,TUNEL阳性细胞数明显增多,Bcl-2表达明显下降,Cas-pase-3表达明显上升;脑血灵颗粒剂及华佗再造丸均能使细胞凋亡的数量减少,同时增加Bcl-2的表达,降低Caspase-3的表达;脑血灵颗粒剂组与华佗再造丸组比较,TUNEL阳性细胞数、Bcl-2表达的降低幅度及Caspase-3表达的上升水平,均有统计学意义(P<0.05)。结论脑血灵颗粒具有显著的抗凋亡活性,从而对脑出血后的继发性神经元损伤具有保护作用。     

神经电生理指标判断昏迷患者预后的评价

昏迷是指由于脑干上行性网状激活系统或大脑皮层神经元广泛受损引起意识丧失,对言语刺激无反应的一种意识障碍。随着医学伦理学的发展,以及为了最有效的利用医疗资源,对昏迷患者进行早期、客观、准确的预后有着愈来愈重要的意义。对于昏迷患者的预后经常采用临床神经系统检查包括脑干反射、疼痛刺激反应和Glasgow昏迷评分(GCS)等,但临床检查判断昏迷患者预后的准确率欠佳[1,2],眼部水肿、气管插管及麻醉药物的持续作用等因素均可影响GCS评分。影像学检查虽然可对病因作出定性、定位诊断,却不能反映病变区的功能障碍,因此难以作为判断预后…     

癫(癎)的电刺激治疗

在癫癎患者中,约有1／3为难治性癫癎患者,尽管有很多新的抗癫癎药物可以供临床医生选择,但是难治性癫癎的发病率并没有下降。应用两种抗癫癎药物而无法有效控制发作者,即使再加用其它抗癫癎药物也不能控制发作。有研究表明,癫癎患者,尤其是难治性癫癎患者,其生活质量和社会功能都受到严重的损害,包括低自卑心理、严重的抑郁、生     

临床拟诊婴儿痉挛症20例脑电图检查结果分析

2001年2月～2006年3月对就诊我院临床拟诊为婴儿痉挛症的20例患者进行常规脑电图（REEG）、动态脑电图（AEEG）、视频脑电图（VEEG）检查，现将检查结果分析如下。     

白介素10抑制大鼠脑缺血再灌注E、L-选择素表达的研究

目的 探讨白介素10(IL-10)对大鼠脑缺血再灌注后E-选择素及L-选择素表达的抑制作用.方法 72只成年雄性SD大鼠随机均分为假手术组,脑缺st/再灌注组,溶剂对照组和IL-10干预组.IL-10干预组经侧脑室注射IL-10(1μg溶解于5μl 5 mol/L NaP),对照组经侧脑室注射溶剂(5μl 5 mol/L NaP).免疫组织化学法、RT-PCR法和Western印迹法检测E-选择素及L-选择素的表达变化.结果 脑缺血再灌注组E-选择素及L-选择素表达明显高于假手术组(P<0.05).IL-10干预组E-选择素及L-选择素阳性血管(18.8±1.9,15.8±2.4)明显少于溶剂对照组(24.7±2.4,20.9±3.3)(P<0.05).IL-10干预组E-选择素及L-选择素基因表达(0.431±0.029,0.318±0.048)明显低于溶剂对照组(0.497±0.019,0.433±0.087)(P<0.05).IL-10干预组E-选择素及L-选择素蛋白表达(0.349±0.037,0.296±0.035)明显低于溶剂对照组(0.421±0.043,0.348±0.044)(P<0.05).结论 IL-10可抑制大鼠脑缺血再灌注后E-选择素及L-选择素的表达.