蛋白激酶C对肿瘤细胞粘附性影响的研究进展

侵袭和转移是恶性肿瘤的重要生物学行为之一,是成功治疗肿瘤的最大障碍。粘附是肿瘤细胞侵袭的第一步,是调节某些肿瘤细胞转移的重要步骤,这种行为可能会影响转移过程中的几个阶段。细胞的聚集、粘附、胞吐(exocytosis)作用及细胞的流动性均是钙参与调节的过程[1,2],而且?..     

经阴道子宫输卵管实时三维超声造影在不孕症诊断中的应用效果

目的 探讨不孕症患者经阴道子宫输卵管实时三维超声造影的诊断价值.方法 选取2018年3月—2019年3月在内蒙古国际蒙医医院进行不孕症治疗的88例患者,依据检查方式不同分为常规组和实验组,每组44例.常规组患者予以X射线子宫输卵管造影检查;实验组患者予以实时三维超声下经阴道子宫输卵管造影检查.持续掌握造影剂显影情况,比...     

网球肘的治疗

目的：就网球肘病因及压痛部位的不同采用不同的治疗方法,以提高治愈率、缩短病程。方法：对３２７例网球肘患者（３６９肘）开始均施以非手术治疗,２６３肘施行了局部封闭治疗。对２８个顽固性网球肘中的１８肘根据其不同情况分别施以改良的Ｂｏｓｗｏｒｔｈ术、改良的Ｂａｕｍｇａｒｄ术、Ｎｉｒｓｃｈｌ术。对伴有相关的周围神经嵌压病变及症状的２２例患者中的８例,施行了相应的神经松解或减压治疗。结果：２４６例患者（２５６肘）得到了６个月以上的随访,优良率９４．５％,治愈率９１．８％。结论：网球肘大多可经非手术疗法而愈,对顽固性网球肘需肘需针对病因及病变部位的不同采取相应的手术方法治疗,只要适应证掌握得当会取得比较满意的效果。同时应注意有关周围神经嵌压病变的诊治。     

纯钛爪型肋骨内固定板在多发肋骨骨折的应用

目的探讨纯钛爪型肋骨内固定板在多发肋骨骨折中的应用。方法选取2010年1月～2012年4月收治的接受纯钛爪型肋骨内固定板治疗的多发性肋骨骨折患者63例为手术组。选择既往接受保守治疗的多发肋骨骨折患者425例为对照组。比较两组患者治疗后VAS疼痛评分、机械通气时间、胸腔引流管放置时间、重症监护室（ICU）监护时间、住院时间及镇痛剂使用情况,肺功能及并发症的发生情况。结果治疗后手术组VAS评分、机械通气时间、胸腔引流管放置时间、ICU监护时间、住院时间及止痛药的使用剂量均明显少于对照组,差异均有统计学意义（均P〈0．05）,手术组肺活量、第1秒用力呼气容积占用力肺活量的百分率（FEV1／FVC）、最大通气量均明显优于对照组,差异均有统计学意义（均P〈0．05）;手术组术后肺不张、肺部感染、胸廓畸形、骨折移位及迟发性气胸等并发症的总发生率为11．1％（7／63）,对照组为47．5％（202／425）,手术组并发症总发生率低于对照组,差异有统计学意义（P〈0．05）。结论纯钛爪型肋骨内固定板治疗多发肋骨骨折的安全有效,相比传统的保守治疗缩短了患者的恢复时间,且并发症较少,故值得推广。     

创伤性肘关节不稳

创伤性肘关节不稳占所有肘部损伤的 11%～ 2 8% ,发生率为 6～ 8例 /10万〔1〕。目前 ,临床上常漏诊或治疗不当 ,可引起复发性或持续性的肱尺关节半脱位、脱位。因此 ,提高对创伤性肘关节不稳的认识与诊治水平势在必行。1　肘关节的稳定结构1 1　骨性结构肱骨远端与尺、桡骨近端的关节面相互适应是维持肘关节稳定性的主要因素 ,其中尺骨的冠状突、鹰嘴以及桡骨的桡骨小头的作用极其重要。Closkey发现尺骨近端冠状突骨折超过5 0 %可引起肘关节的复发性脱位和半脱位〔2〕。生物力学研究中发现鹰嘴大部切除会产生肘关节的不稳〔3〕。桡骨小头…     

关节镜下同种异体组织重建膝关节前后交叉韧带的临床研究

目的　评价关节镜下同种异体组织重建膝关节前后交叉韧带 (ACL ,PCL)的疗效。方法　回顾调查了 36例孤立性交叉韧带损伤病人 ,将其分为 2组 ,A组 :ACL损伤 2 8例 ;B组 :PCL损伤 8例。分别应用同种异体B -PT -B、半腱与股薄肌腱、胫后肌腱、跟腱 -骨和四头肌腱 -骨重建 ,平均随访 2 1 5个月。结果　Lysholm评分 :A组术前平均 6 3± 5 6 ;术后 90±5 5 ;B组术前平均 6 1± 7 6 ,术后 88± 6 0 ;两组手术前后差异显著 (P <0 0 1) ;IKDC评分 :A组A级 2例 (7% ) ,B级 16例 (5 7% ) ,C级 8例 (2 9% ) ,D级 2例 (7% ) ;B组A级 1例 (12 5 % ) ,B级 3例 (37 5 % ) ,C级 3例 (37 5 % ) ,D级 1例 (12 5 % )。KT2 0 0 0测定 :A组由术前胫骨前移平均 11 90± 0 2 7mm减少至术后 4 30± 1 4 2mm ;B组胫骨后移由术前平均 10 5± 2 5mm减少至术后 5 9± 1 5mm ,两组手术前后有显著差异 (P <0 0 1)。术后健患侧比较 :A组平均 2 3± 0 9mm ;B组 2 7± 1 3mm ;健患差异 :A组 <3mm2 3/ 2 8例 (82 % ) ,>5mm 3例 (11% ) ;B组 <3mm 5 / 8例 (6 2 5 % ) ,>5mm 2例 (2 5 % )。前后抽屉试验大部分平均恢复 1°以上 ,并呈现明显的硬终点。术后ROM ,A组 :正常 2 6 / 2 8例 (93% ) ,接近正常 2 / 2 8例 (7% ) ;B组 :     

透明质酸复合BMP-2转染的兔骨髓基质干细胞在裸鼠肌内成骨的实验研究

我们通过动物实验，对高分子量透明质酸(hyaluronic acid，HA)复合腺病毒介导的人骨形态发生蛋白-2基因(Adv-hBMP-2)体外转染兔骨髓基质干细胞(BMSCs)裸鼠肌内成骨与成软骨能力进行了观察。     

纤维多孔钛微球复合纳米锶磷灰石修复骨缺损的实验研究

Objective To evaluate the effect of titanium fiber mesh microballoons combined with nano-Sr-HAP on repair of bone defects in vivo. Methods The experimental model was set up by creating drill defects in the bilateral femoral condyle of 24 SD rats [6 months, with the mean weight of (545±22 g)]. The left femoral defects were filled with titanium fiber mesh microballoons combined with nano-Sr-HAP, and the right with pure metal scaffolds. At the 1st, 2nd, 4th, and 8th week after surgery, the specimens were killed and taken the X-ray, histology, and histomorphology observation. The results were contrasted and ana-lyzed. Results X-ray observation showed that the bone defects in both sides were repaired. Histological re-sults showed that the titanium fiber mesh microballoons allowed the new bones growing inside, and more new bones in the left implants compared with those in the right sides. The results of histomorphometrical analysis confirmed that neo-bones in the left sides gradually increased as time passed. There were statistic differences in neo-bones at the 2nd, 4th, and 8th week, and the differences between the two sides were statistically sig-nificant at the 4th and 8th week. Conclusion As titanium fiber mesh microballoons used in this experiment have good biocompatibility and osteoconduction ability, they can be used as scaffold for bone defect repair; and Nano-Sr-HAP can enhance the repair ability of titanium fiber mesh.     

上海地区骨质疏松性骨折的发病特点研究（附5923例分析）

目的 通过分析上海地区中老年人发生骨质疏松性骨折的部位、性别、年龄等,阐明该地区骨质疏松性骨折的发病特点,为骨质疏松性骨折的防治提供理论依据.方法 回顾2000年1月至2005年12月在我院因脆性骨折就诊的中老年患者5923例,按患者性别、年龄、骨折部位等进行归纳、分析及总结.结果 60岁以上女性骨折发生数明显多于男性,其中,常见部位骨折最高发生率的年龄分别为：桡骨远端骨折为70岁;股骨颈骨折为75岁;股骨粗隆间骨折为80岁.各年龄组女/男数据比较：60岁以后各年龄段的女/男值与总计中的女/男值1.96相比差异显著（P＜0.05）,表明按年龄段划分有统计学意义,60岁以后女性发生骨折的几率明显高于男性.结论 60岁以后女性骨折发生率明显多于男性,桡骨远端骨折、股骨颈骨折、股骨粗隆间骨折发病高峰的年龄各有不同,应在骨质疏松性骨折的防治中引起重视,并区别对待.     

纤维多孔钛微球复合纳米锶磷灰石修复骨缺损的实验研究

Objective To evaluate the effect of titanium fiber mesh microballoons combined with nano-Sr-HAP on repair of bone defects in vivo. Methods The experimental model was set up by creating drill defects in the bilateral femoral condyle of 24 SD rats [6 months, with the mean weight of (545±22 g)]. The left femoral defects were filled with titanium fiber mesh microballoons combined with nano-Sr-HAP, and the right with pure metal scaffolds. At the 1st, 2nd, 4th, and 8th week after surgery, the specimens were killed and taken the X-ray, histology, and histomorphology observation. The results were contrasted and ana-lyzed. Results X-ray observation showed that the bone defects in both sides were repaired. Histological re-sults showed that the titanium fiber mesh microballoons allowed the new bones growing inside, and more new bones in the left implants compared with those in the right sides. The results of histomorphometrical analysis confirmed that neo-bones in the left sides gradually increased as time passed. There were statistic differences in neo-bones at the 2nd, 4th, and 8th week, and the differences between the two sides were statistically sig-nificant at the 4th and 8th week. Conclusion As titanium fiber mesh microballoons used in this experiment have good biocompatibility and osteoconduction ability, they can be used as scaffold for bone defect repair; and Nano-Sr-HAP can enhance the repair ability of titanium fiber mesh.