Clinical study of the efficacy of interferon-α therapy for HBeAg-negative chronic hepatitis B patients

Objective To investigate the effect of IFN-α therapy for HBeAg-negative ehronie hepatitis B(CHB). Methods 50 cases of HBeAg-negative CHB patients were selected as treated group, while 52 cases of HBeAg-positive CHB as control group. Both groups received injection of IFN-α at dose of 6 MU every other day for 48 weeks. Levels of alanine aminotransferase, viral markers levels of HBeAg, HBV DNA and the four serum fibrosis markers were analysed before and after treatment and 24 weeks after the course. Results There were 36 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment. And the rates of efficacy were 72% and 50% separately. The rate of treated group was higher than that of control group(X2 = 5.43, P <0.05). The four serum fibrosis markers of the both groups were clearly dropped after treatment (t = 2.365, P < 0.05). Conclusions The theraputie effects of IFN-α at dose of 6 MU for HBeAg-negative CHB is prior to HBeAg-positive CHB. And IFN-α also have an evident funtion on preventing or delaying hepatic fibrosis in patients with CHB.     

下腔静脉阻塞综合征的介入治疗(附7例报告)

血管内支架 (ＥＭＳ)置入术是近年来国内外用于治疗血管狭窄或闭塞的介入放射学新技术 ,球囊导管成形术 (ＰＴＡ)和血管内支架置入术治疗下腔静脉阻塞综合征 (ＩｎｆｅｒｉｏｒＶｅｎａＣａｖａＳｙｎｄｒｏｍｅ,ＩＶＣＳ) ,国内已有不少病例报道 ,并取得了较好的临床效果 ,但有关ＩＶＣＳ病因及肿瘤致下腔静脉阻塞的腔外肿瘤ＣＴ介入治疗的报道较少。我院于 2 0 0 0年 1月—2 0 0 1年 12月 ,共收集 7例ＩＶＣＳ病例进行总结 ,现将有关ＩＶＣＳ的病因及诊断治疗问题进行研究讨论 ,并探讨肿瘤致下ＩＶＣＳ病例行腔外肿瘤ＣＴ介入治疗的疗效。…     

Clinical study of the efficacy of interferon-α therapy for HBeAg-negative chronic hepatitis B patients

Objective To investigate the effect of IFN-α therapy for HBeAg-negative ehronie hepatitis B(CHB). Methods 50 cases of HBeAg-negative CHB patients were selected as treated group, while 52 cases of HBeAg-positive CHB as control group. Both groups received injection of IFN-α at dose of 6 MU every other day for 48 weeks. Levels of alanine aminotransferase, viral markers levels of HBeAg, HBV DNA and the four serum fibrosis markers were analysed before and after treatment and 24 weeks after the course. Results There were 36 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment. And the rates of efficacy were 72% and 50% separately. The rate of treated group was higher than that of control group(X2 = 5.43, P <0.05). The four serum fibrosis markers of the both groups were clearly dropped after treatment (t = 2.365, P < 0.05). Conclusions The theraputie effects of IFN-α at dose of 6 MU for HBeAg-negative CHB is prior to HBeAg-positive CHB. And IFN-α also have an evident funtion on preventing or delaying hepatic fibrosis in patients with CHB.     

Clinical study of the efficacy of interferon-α therapy for HBeAg-negative chronic hepatitis B patients

Objective To investigate the effect of IFN-α therapy for HBeAg-negative ehronie hepatitis B(CHB). Methods 50 cases of HBeAg-negative CHB patients were selected as treated group, while 52 cases of HBeAg-positive CHB as control group. Both groups received injection of IFN-α at dose of 6 MU every other day for 48 weeks. Levels of alanine aminotransferase, viral markers levels of HBeAg, HBV DNA and the four serum fibrosis markers were analysed before and after treatment and 24 weeks after the course. Results There were 36 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment. And the rates of efficacy were 72% and 50% separately. The rate of treated group was higher than that of control group(X2 = 5.43, P <0.05). The four serum fibrosis markers of the both groups were clearly dropped after treatment (t = 2.365, P < 0.05). Conclusions The theraputie effects of IFN-α at dose of 6 MU for HBeAg-negative CHB is prior to HBeAg-positive CHB. And IFN-α also have an evident funtion on preventing or delaying hepatic fibrosis in patients with CHB.     

胸廓出口综合征的电生理特征

胸廓出口综合征是臂丛神经血管和锁骨下动静脉在胸廓出口处和胸小肌在肩胛骨的喙突附着处受压而引起的临床综合征。文章通过对20例临床诊断符合胸廓出口综合征的患者进行正中神经、尺神经、前臂内、外侧皮神经、肩胛上神经、腋神经、肌皮神经、桡神经传导速度、波幅及相应肌肉针电极肌电图检测,探讨神经电生理检测对胸廓出口综合征的诊断意义及临床诊断的一致性。1对象与方法1.1对象1998年4月～1999年7月大连市中心医院神经内外科、手外科及门诊确诊为胸廓出口综合征的患者20例,男5例,女15例。年龄31～67岁,平均46.0岁。病程2～7年,平均4.5…     

电子束CT与CT在诊断肝脏疾病的比较研究

目的 :分析普通CT和电子束CT在肝脏疾病辅助性诊断中的意义。方法 :收集 35例有临床症状和生化改变的各种肝脏疾病的患者 ,分别行普通CT和电子束CT(EBCT)扫描 ,帮助确诊并分析其结果。结果 :EBCT对上述35例肝脏疾病的确诊率为 10 0 % ,优于CT(77.1% )。结论 :EBCT不仅在心血管疾病应用方面有独特的优势 ,在肝脏疾病应用方面也优于普通CT。     

糖尿病周围神经病变的电生理检测

目的：探讨电生理检测对糖尿病周围神经病的诊断意义。方法：对100例糖尿病患测定正中神经肘→腕运动神经传导速度、波幅，指1→腕感觉神经传导速度、波幅。迟神经肘→腕运动神经传导速度、波幅，指5→腕感觉神经传导速度、波幅。胫后神经Guo→踝运动神经传导速度、波幅，趾1→踝感觉神经传导速度、波幅。腓总神经膝→踝运动神经传导速度、波幅。腓肠神经外踝→腓肠点感觉神经传导速度及波幅。结果：糖尿病周围神经病以轴索及髓鞘同时受损多见，在四肢各神经中，感觉神经传导速度减慢及波幅降低较多，复合肌肉动作电位波幅降低次之，而运动神经传导速度受累较少见。结论：神经电生理检查对糖尿病周围神经病诊断具有重要意义。     

NK 细胞联合红花多糖对结肠癌细胞的杀伤作用及机制研究

目的:观察自然杀伤细胞(NK)联合红花多糖(SPS)杀伤结肠癌细胞的协同效应并初步探讨作用机制。方法:四甲基偶氮唑盐比色法(MTT)检测SPS对结肠癌细胞增殖的影响;钙黄绿素-AM释放法分析NK与SPS对结肠癌细胞的杀伤效率;ELISA及流式细胞术(FCM)分析TNF-α、IFN-γ及NKp46、MICA、MICB、ULBP1的表达水平。结果:SPS对结肠癌细胞的增殖抑制率与作用时间和浓度成正比,促NK细胞增殖的最高阈值浓度为0.625 mg/ml;NK与SPS联合组的杀伤效率及TNF-α/IFN-γ分泌显著高于NK组和SPS组(P0.05);各实验组NK细胞的NKp46、MICA、MICB、ULBP1表达均升高(P0.05)。结论:NK细胞与SPS对体外杀伤结肠癌细胞具有协同作用,其作用机制可能与SPS调控NK细胞TNF-α、IFN-γ分泌及活化性受体和活化性配体表达水平有关。     

白细胞介素-7研究新进展

白细胞介素-7(interleukin-7,IL-7)最早在1988年以pre-B细胞刺激因子的角色被发现,由Namen等从一单克隆鼠骨髓基质细胞株(IXN/A6)培养液中分离提纯,并以淋巴细胞生长因子-1(lymphopoetin 1,LP-1)命名[1];后因发现其不同于其他白细胞介素,故统一更名为IL-7[2].